1-Desamino[8-D-arginine]Vasopressin (dDAVP) Decreases Blood Pressure and Increases Pulse Rate in Normal Individuals

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Title: 1-Desamino[8-D-arginine]Vasopressin (dDAVP) Decreases Blood Pressure and Increases Pulse Rate in Normal Individuals
Authors: Bichet, Daniel G.; Razi, Mohammad; Lonergan, Michele; Arthus, Marie-Francoise
Publisher: Thrombosis and Haemostasis
Date Published: October 31, 1988
Reference Number: 453
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This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. We concentrated our translation on those aspects of the article dealing directly with NDI. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder.
© Copyright NDI Foundation 2007 (JC)

Bichet, et al., report on the results of their use of dDAVP, a synthetically modified analog of the hormone, vasopressin (VP). They found that an administration of 0.3 micrograms of dDAVP per kilogram of the patients' body weight (up to a maximum of 24 microgram infusion in 20 minutes) regularly decreased the patient's mean arterial pressure by 10 - 15% and increased their pulse by 20-30%. These changes occurred at the end of the 20 minute dDAVP administration and reversed back to normal over the following 60 -90 minutes. The authors report that other researchers have observed slight decreases in blood pressure immediately after and up to one hour after dDAVP infusion.

Bichet, et al., alert the readers that the changes induced by dDAVP in people being treated for hemorrhagic disorders could be misinterpreted as indicative of active bleeding. They also discourage administering dDAVP intravenously in a concentrated mass.