125I-d(CH2)5[Tyr(Me)2, Tyr(NH2)9]AVP: Iodination and Binding Characteristics of a Vasopressin Receptor Ligand

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Title: 125I-d(CH2)5[Tyr(Me)2, Tyr(NH2)9]AVP: Iodination and Binding Characteristics of a Vasopressin Receptor Ligand
Authors: Elands, Jack; Barberis, Claude; Jard, Serge; Lammek, Bernard; Manning, Ph.D., D.Sc., Maurice; Sawyer, Wilbur H.; de Kloet, E.
Publisher: FEBS Letters
Date Published: March 14, 1988
Reference Number: 364
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A radioiodinated vasopressin antagonist, d(CH2)5[Tyr(NH2)9]AVP has been prepared. Iodination was carried out at the phenyl moiety of the tyrosylamide residue at position 9, followed by HPLC purification. Non-radiolabelled monoiodinated antagonist was used as a reference for identification. 125I-d(CH2)5[Tyr(Me)2, Tyr(NH2)9]AVP binding appeared to take place with a dissociation constant of 0.28 +/- 0.09 nM (Kd +/- SD) to V1 vasopressin receptors on rat liver membranes.
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