Acquired Nephrogenic Diabetes Insipidus Secondary to Distal Renal Tubular Acidosis and Nephrocalcinosis Associated with Sjogren's Syndrome
|Title:||Acquired Nephrogenic Diabetes Insipidus Secondary to Distal Renal Tubular Acidosis and Nephrocalcinosis Associated with Sjogren's Syndrome|
|Authors:||Nagayama, MD, Yuji; Shigeno, M.; Nakagawa, Y.; Suganuma, A.; Takeshita, A.; Fujiyama, K.; Ashizawa, K.; Kiriyama, T.; Yokoyama, N.; Nagataki, S.|
|Publisher:||Journal of Endocrinological Investigation|
|Date Published:||September 01, 1994|
This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. We concentrated our translation on those aspects of the article dealing directly with NDI. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder.
© Copyright NDI Foundation 2007 (JC)
Sjogren's syndrome is characterized by dryness of the mouth or parotid gland swelling, dryness of the eyes and arthritis. Kidney complications are frequently associated with this syndrome.
The acidosis in the woman's kidney tubules rendered them unable to acidify urine. This results in high urinary calcium concentrations which leads to nephrocalcinosis, which adversely affects the kidney's ability to function.
Though it is not clear that the woman's nephrocalcinosis caused her NDI, the authors noted that the calcium deposits resulting from her nephrocalcinosis collect around the part of the tubule where the antidiuretic hormone, arginine vasopressin (AVP) exerts its influence. NDI is characterized by the kidney's inability to respond to AVP. But, it could also be that Sjogren's syndrome's ability to infiltrate kidney tissue may interfere with the tubules capacity to allow water to pass through them. It was clear, however, that the woman's long-standing tubular acidosis resulted in nephrocalcinosis and NDI. And the authors state that in patients with kidney tubular acidosis and/or NDI of unknown cause, the possibility of Sjogren's syndrome should be considered.