Oxytocin Induces Apical and Basolateral Redistribution of Aquaporin-2 in Rat Kidney
|Title:||Oxytocin Induces Apical and Basolateral Redistribution of Aquaporin-2 in Rat Kidney|
|Authors:||Jeon, Un Sil; Joo, Kwon Wook; Na, Ki Young; Kim, Yon Su; Lee, Jung Sang; Kim, Jin; Kim, Gheun-Ho; Nielsen, Soren; Knepper, Mark; Han, Jin Suk|
|Date Published:||January 01, 2003|
This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. We concentrated our translation on those aspects of the article dealing directly with NDI. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder.
© Copyright NDI Foundation 2007 (JC)
Vasopressin (AVP) is a hormone that initiates the molecular sequence that sends AQP2 to the apical membrane in kidney collecting duct cells. However, recent studies indicate that factors other than AVP may contribute to the cell’s ability to let water cross its membrane. Jeon, et al., speculated that the hormone, oxytocin, might play a role in redistributing AQP2 from the cell interior to the cell membrane that is independent from AVP. They introduced oxytocin into rats to see the effect on their ability to concentrate urine, then they examined their collecting duct cells to determine the effect of oxytocin on AQP2 movement to the cell membrane.
The research team discovered that oxytocin does help concentrate urine. The researchers also discovered that oxytocin can cause AQP2 to travel from the cell interior to both the apical and basolateral sections of the membrane in the principal cells of the kidney collecting duct and connecting tubule. When the team prevented the vasopressin-2 receptor (V2R) from linking with AVP, oxytocin could not cause the AQP2 to travel to the cell membranes. This suggests that the V2R in some way helps oxytocin to have its translocation effect on AQP2.
The researchers note that AVP, which signals AQP2 to travel to the apical membrane, and oxytocin, which signals it to travel to both the apical and basolateral membrane, must link with the same hormone receptor protein, V2R. They suggest this phenomenon is ripe for further research.