Renal Histology in a Patient with Nephrogenic Diabetes Insipidus

Title: Renal Histology in a Patient with Nephrogenic Diabetes Insipidus
Authors: Hironaka, MD, Kazue; Makino, Hirofumi; Ogura, Toshio; Ota, Zensuke
Publisher: Nephron
Date Published: January 01, 1995
Reference Number: 82

This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. We concentrated our translation on those aspects of the article dealing directly with NDI. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder.
© Copyright NDI Foundation 2007 (JC)

Nephrogenic diabetes insipidus (NDI) is a disorder characterized by the kidney's inability to respond to the antidiuretic hormone,arginine vasopressin (AVP). It is related to an abnormality located in the nephron binding sites. The nephrons are the main working unit of the kidney. They consist of a filtering unit called a glomerulus and a little tube called a tubule. Binding sites are locations wherehormones bind with their receptors to begin a molecular sequence which instigates a physiologic response. The primary symptoms of NDI are polyuria (chronic passage of large volumes of urine) and polydipsia (chronic, excessive thirst).

Some studies have found other abnormalities in other parts of the kidney tissue in addition to the nephrons which may be specific to NDI, but the findings have not been conclusive. Hironak, et al., examined the kidney tissue of a 16-year-old male NDI patient and found it normal except for a minor abnormality in the section of the tubule closest to the glomerulus.