Amphotericin B-Induced Partial Nephrogenic Diabetes Insipidus in a Child
| Title: | Amphotericin B-Induced Partial Nephrogenic Diabetes Insipidus in a Child |
|---|---|
| Authors: | Hopp, Laszlo; Bernardi, John; Reeves, Grafton |
| Publisher: | Pediatric Nephrology |
| Date Published: | July 01, 2001 |
| Reference Number: | 520 |
The case of a 12-year-old boy who developed polyuria and polydipsia while on amphotericin B treatment is discussed. The clinical and laboratory features are most consistent with partial nephrogenic diabetes insipidus. Several adult patients have been reported with amphotericin B-induced nephrogenic diabetes insipidus. To the knowledge of the authors, this is the first pediatric patient described with this condition. Pharmacological doses of antidiuretic hormone in conjunction with diuretic treatment significantly reduced the polyuria and alleviated the associated symptoms. The authors propose that in amphotericin B-induced partial nephrogenic diabetes insipidus, pharmacological doses of antidiuretic hormone may offer an additional benefit to commonly used diuretic therapy.
This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. We concentrated our translation on those aspects of the article dealing directly with NDI. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder.
© Copyright NDI Foundation 2007 (JC)
The child's condition was such that amphotericin B use could not be discontinued, so he was treated with desmopressin, a synthetic form of the antidiuretic hormone (AVP) along with the diuretics amiloride and spironolactone. Later, the diuretic hydrochlorothiazide was added to the treatment regime. This treatment significantly reduced the patient's excessive urination.