Water Channels in Health and Disease
|Title:||Water Channels in Health and Disease|
|Date Published:||May 01, 1998|
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This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. We concentrated our translation on those aspects of the article dealing directly with NDI. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder.
© Copyright NDI Foundation 2007 (JC)
Disorders in either the V2R or AQP2 are the molecular basis of nephrogenic diabetes insipidus (NDI). NDI is a disorder characterized by the kidneys' inability to concentrate urine in response to vasopressin. The primary symptoms of NDI are polyuria (the chronic passage of large volumes of urine) and polydipsia (chronic, excessive thirst).