nephrogenic diabetes insipidus

DEFINITION:

A syndrome of polyuria and hyposthenuria caused by the failure of the renal tubules to reabsorb water in response to antidiuretic hormone, without disturbance in the renal filtration and solute excretion rates; the condition does not respond to exogenous vasopressin. It may be inherited as a rare X-linked trait or be acquired as a result of drug therapy or systemic disease.

nephrologist

DEFINITION:

An expert in the study of the kidney, its anatomy, physiology, pathology, and pathophysiology.

pediatric

DEFINITION:

Pertaining to pediatrics.

nephrologist

DEFINITION:

An expert in the study of the kidney, its anatomy, physiology, pathology, and pathophysiology.

endocrinologist

DEFINITION:

Any individual who studies hormones or specializes in the diagnosis and treatment of disorders of the glands of internal secretion, i.e., the endocrine glands.

gene

DEFINITION:

A segment of a DNA molecule that contains all the information required for synthesis of a product (polypeptide chain or RNA molecule), including both coding and non-coding sequences. It is the biological unit of heredity, self-reproducing, and transmitted from parent to progeny. Each gene has a specific position (locus) on the chromosome map. From the standpoint of function, genes are conceived of as structural, operator, and regulatory genes.

wild-type gene - The normal allele of a gene, sometimes symbolized by +.

X-linked gene - A gene carried on the X chromosome; the corresponding trait, whether dominant or recessive, is always expressed in males, who have only one X chromosome. X linkage is used sometimes synonymously with sex linkage since no genetic disorders have as yet been associated with genes on the Y chromosome.

association

DEFINITION:

1. A state in which two attributes occur together either more or less often than expected by chance.

2. In neurology, a term applied to those regions of the brain that link the primary motor and sensory cortices; see association areas.

3. In genetics, the occurrence together of two or more phenotypic characteristics more often than would be expected by chance.

4. In psychiatry, a connection between ideas or feelings, especially between conscious thoughts and elements of the unconscious, or the formation of such a connection.

NDI

DEFINITION:

Nephrogenic diabetes insipidus.

NDI

DEFINITION:

Nephrogenic diabetes insipidus.