NDI

DEFINITION:

Nephrogenic diabetes insipidus.

gene

DEFINITION:

A segment of a DNA molecule that contains all the information required for synthesis of a product (polypeptide chain or RNA molecule), including both coding and non-coding sequences. It is the biological unit of heredity, self-reproducing, and transmitted from parent to progeny. Each gene has a specific position (locus) on the chromosome map. From the standpoint of function, genes are conceived of as structural, operator, and regulatory genes.

wild-type gene - The normal allele of a gene, sometimes symbolized by +.

X-linked gene - A gene carried on the X chromosome; the corresponding trait, whether dominant or recessive, is always expressed in males, who have only one X chromosome. X linkage is used sometimes synonymously with sex linkage since no genetic disorders have as yet been associated with genes on the Y chromosome.

inherited NDI

DEFINITION:

NDI due to a gene mutation passed from parent(s) to child.

X-linked NDI

DEFINITION:

A form of diabetes insipidus, inherited as an X-linked trait, caused by failure of the renal tubules to reabsorb water in response to antidiuretic hormone, without disturbance in the renal filtration and solute excretion rates; the condition does not respond to exogenous vasopressin.

NDI

DEFINITION:

Nephrogenic diabetes insipidus.

carrier

DEFINITION:

1. An individual who harbors the specific organisms of a disease without manifest symptoms and is capable of transmitting the infection; the condition of such an individual is referred to as the carrier state.

2. Electron carrier; a chemical substance that can accept one or more electrons and then donate them to another substance (being reduced and then reoxidized).

3. An instrument or apparatus for carrying something.

4. In genetics, an individual who is heterozygous for a recessive gene and thus does not express the recessive phenotype but can transmit it to offspring. Only females can be carriers of X-linked recessive traits.

5. A substance that carries a radioisotopic or other label, as in a tracer study. A second isotope mixed with a particular isotope is also referred to as a carrier.

6. A transport protein that carries specific substances, e.g., in the blood or across cell membranes.

7. In immunology, a macromolecular substance to which a hapten is coupled in order to produce an immune response against the hapten, immune responses being usually produced only against large molecules capable of simultaneously binding both B cells and helper T cells.

NDI

DEFINITION:

Nephrogenic diabetes insipidus.

genetic

DEFINITION:

1. Relating to or determined by the origin, development, or causal antecedents of something.

2. Of, relating to, or being a gene.

carrier

DEFINITION:

1. An individual who harbors the specific organisms of a disease without manifest symptoms and is capable of transmitting the infection; the condition of such an individual is referred to as the carrier state.

2. Electron carrier; a chemical substance that can accept one or more electrons and then donate them to another substance (being reduced and then reoxidized).

3. An instrument or apparatus for carrying something.

4. In genetics, an individual who is heterozygous for a recessive gene and thus does not express the recessive phenotype but can transmit it to offspring. Only females can be carriers of X-linked recessive traits.

5. A substance that carries a radioisotopic or other label, as in a tracer study. A second isotope mixed with a particular isotope is also referred to as a carrier.

6. A transport protein that carries specific substances, e.g., in the blood or across cell membranes.

7. In immunology, a macromolecular substance to which a hapten is coupled in order to produce an immune response against the hapten, immune responses being usually produced only against large molecules capable of simultaneously binding both B cells and helper T cells.