What are the long-term side effects of the medications?

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Topic: Medications
Author: Bichet, Daniel G.
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The significant side-effects of indomethacin, especially with long-term use, are gastrointestinal bleeding and ulceration, kidney toxicity, hyperkalemia (excessive potassium in the plasma), hyponatremia (abnormally low plasma levels of sodium).Indomethacin may cause fluid retention, peripheral edema and liver toxicity. The central nervous system can also be negatively effected.

The significant side-effects of hydrochlorothiazide, especially with doses greater than 50mg/day, can be hypokalemia (abnormally low plasma levels of potassium), hyperuricemia (excessive uric acid or urates in the blood), decreased glucose tolerance, and an increase in serum TRG and cholesterol. These side-effects also can occur with chlorothiazide. Since both these thiazide diuretics rob the body of potassium, there is also a possible risk of cardiac arrhythmia. Clinicians must often administer potassium salts along with these diuretics, and this may cause severe gastrointestinal complications.

There seems to be only one significant side-effect of amiloride use, and this would be to induce hyperkalemia. This is more likely to occur if the person taking amiloride already has compromised kidney function. Several studies have indicated that prolonged use of amiloride in combination with hydrochlorothiazide is usually well-tolerated.