Maxide is a brand-name diuretic to treat high-blood pressure. In my case, however, this diuretic causes my system to require less water intake and therefore less fluid output. Have you heard of this reverse-effect on persons with diabetes insipidus?

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Topic: Medications
Author: Robertson, Gary
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It is not surprising that Maxide reduces your urine output and fluid intake because it is the trade name for a combination of drugs that contains hydrochlorothiazide. Hydrochlorothiazide is one of the drugs known to be effective in reducing urine output in nephrogenic diabetes insipidus. The primary mechanism of action is on the kidney to reduce urine output. This reduces dehydration which secondarily reduces thirst and fluid intake.