Early Onset Bilateral Calcifications and Epilepsy
| Title: | Early Onset Bilateral Calcifications and Epilepsy |
|---|---|
| Authors: | Nunes, Magda Lahorgue; Costa da Costa, Jaderson; Severini, Marcia H. |
| Publisher: | Pediatric Neurology |
| Date Published: | July 01, 1995 |
| Reference Number: | 61 |
Bilateral occipital calcifications associated with epilepsy and sometimes with celiac disease have been described previously. A body with bilateral frontal and occipital diffuse calcifications accompanied by failure to thrive, nephrogenic diabetes insipidus, developmental delay and seizures, but without celiac disease is presented. Follow-up at 3 years of age disclosed neurodevelopmental delay, height and weight less than expected for age, and seizures controlled with carbamazepine. The uncommon association of these features and the early onset of symptoms is discussed. Although bilateral occipital calcifications share some clinical features with bilateral fronto-occipital calcifications, it is arguable whether the two are on a spectrum of a single disease or represent separate entities.
This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. We concentrated our translation on those aspects of the article dealing directly with NDI. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder.
© Copyright NDI Foundation 2007 (JC)
Patients with diabetes insipidus (DI) often have significant intracranial pathologic conditions. Other conditions associated with DI are tumors, central nervous system malformations, trauma, infections, leukemia, the presence of cells capable of ingesting particulate matter, and Hodgkin's disease.
Though some researchers have hypothesized that bilateral calcification of the brain can cause DI, at present it is not clear why these two conditions may sometimes be associated with one another.