autosomal-dominant

DEFINITION:

A pattern of inheritance characterized by transmission from one generation to the next with no sex predilection. Autosomal refers to the chromosomes other than the sex chromosomes, i.e., autosomes(Crawford).

renal disease

DEFINITION:

See kidney disorders .

characterized

DEFINITION:

Marked or distinguished as a characteristic.

gouty arthritis

DEFINITION:

Arthritis due to gout.

renal disease

DEFINITION:

See kidney disorders .

localization

DEFINITION:

1. The determination of the site or place of any process or lesion.
2. Restriction to a circumscribed or limited area.
3. Prelocalization.

gene

DEFINITION:

A segment of a DNA molecule that contains all the information required for synthesis of a product (polypeptide chain or RNA molecule), including both coding and non-coding sequences. It is the biological unit of heredity, self-reproducing, and transmitted from parent to progeny. Each gene has a specific position (locus) on the chromosome map. From the standpoint of function, genes are conceived of as structural, operator, and regulatory genes.

wild-type gene - The normal allele of a gene, sometimes symbolized by +.

X-linked gene - A gene carried on the X chromosome; the corresponding trait, whether dominant or recessive, is always expressed in males, who have only one X chromosome. X linkage is used sometimes synonymously with sex linkage since no genetic disorders have as yet been associated with genes on the Y chromosome.

polyuria

DEFINITION:

The passage of a large volume of urine in a given period, a characteristic of diabetes.

nephrogenic diabetes insipidus

DEFINITION:

A syndrome of polyuria and hyposthenuria caused by the failure of the renal tubules to reabsorb water in response to antidiuretic hormone, without disturbance in the renal filtration and solute excretion rates; the condition does not respond to exogenous vasopressin. It may be inherited as a rare X-linked trait or be acquired as a result of drug therapy or systemic disease.

hypertension

DEFINITION:

Abnormally high blood pressure and especially arterial blood pressure.

short arm

DEFINITION:

The shorter of the two segments of the chromosome separated by the centromere; the symbol p indicates the short arm and q the long arm.

linkage

DEFINITION:

1. The connection between different atoms in a chemical compound, or the symbol representing it in structural formulas; See also bond .
2. In genetics, the association of genes having loci nearby on the same chromosome, which results in the tendency of a group of such nonallelic genes to be associated in inheritance.

negative

DEFINITION:

1. Marked by denial, prohibition, or refusal.
2. Not positive or constructive.
3. Less than zero.
4. Being, relating to, or charged with electricity of which the electron is the elementary unit.
5. Having the light and dark parts opposite to what they were in the original photographic subject.

localization

DEFINITION:

1. The determination of the site or place of any process or lesion.
2. Restriction to a circumscribed or limited area.
3. Prelocalization.

gene

DEFINITION:

A segment of a DNA molecule that contains all the information required for synthesis of a product (polypeptide chain or RNA molecule), including both coding and non-coding sequences. It is the biological unit of heredity, self-reproducing, and transmitted from parent to progeny. Each gene has a specific position (locus) on the chromosome map. From the standpoint of function, genes are conceived of as structural, operator, and regulatory genes.

wild-type gene - The normal allele of a gene, sometimes symbolized by +.

X-linked gene - A gene carried on the X chromosome; the corresponding trait, whether dominant or recessive, is always expressed in males, who have only one X chromosome. X linkage is used sometimes synonymously with sex linkage since no genetic disorders have as yet been associated with genes on the Y chromosome.

gene

DEFINITION:

A segment of a DNA molecule that contains all the information required for synthesis of a product (polypeptide chain or RNA molecule), including both coding and non-coding sequences. It is the biological unit of heredity, self-reproducing, and transmitted from parent to progeny. Each gene has a specific position (locus) on the chromosome map. From the standpoint of function, genes are conceived of as structural, operator, and regulatory genes.

wild-type gene - The normal allele of a gene, sometimes symbolized by +.

X-linked gene - A gene carried on the X chromosome; the corresponding trait, whether dominant or recessive, is always expressed in males, who have only one X chromosome. X linkage is used sometimes synonymously with sex linkage since no genetic disorders have as yet been associated with genes on the Y chromosome.