drug

DEFINITION:

1. A chemical substance that affects the processes of the mind or body.

2. Any chemical compound used on or administered to humans or animals as an aid in the diagnosis, treatment, or prevention of disease or other abnormal condition, for the relief of pain or suffering, or to control or improve any physiologic or pathologic condition.

3. A substance used recreationally for its effects on the central nervous system, such as a narcotic; abuse may lead to dependence or addiction.

4. To administer a drug to.

indomethacin

DEFINITION:

A nonsteroidal anti-inflammatory agent; used in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

nephrogenic diabetes insipidus

DEFINITION:

A syndrome of polyuria and hyposthenuria caused by the failure of the renal tubules to reabsorb water in response to antidiuretic hormone, without disturbance in the renal filtration and solute excretion rates; the condition does not respond to exogenous vasopressin. It may be inherited as a rare X-linked trait or be acquired as a result of drug therapy or systemic disease.

NDI

DEFINITION:

Nephrogenic diabetes insipidus.

indomethacin

DEFINITION:

A nonsteroidal anti-inflammatory agent; used in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

urine volume

DEFINITION:

The measure of the quantity of urine, e.g., excreted from the kidneys.

congenital NDI

DEFINITION:

Congenital nephrogenic diabetes insipidus. A condition of the kidneys existing at birth.

urine volume

DEFINITION:

The measure of the quantity of urine, e.g., excreted from the kidneys.

NDI

DEFINITION:

Nephrogenic diabetes insipidus.

lithium

DEFINITION:

A white metal; atomic number, 3. Lithium salts (lithium carbonate and lithium citrate) are used in treating the manic phase of bipolar disorder.

lithium carbonate - [USP], chemical name: carbonic acid dilithium salt. A white, granular powder, Li₂CO₃, used in the treatment of acute manic states and in the prophylaxis of recurrent affective disorders manifested by depression or mania only, or those in which both mania and depression occur occasionally, administered orally.

lithium citrate - The citrate salt of lithium, used to treat the manic phase of bipolar disorder.

indomethacin

DEFINITION:

A nonsteroidal anti-inflammatory agent; used in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

urine volume

DEFINITION:

The measure of the quantity of urine, e.g., excreted from the kidneys.

inhibiting

DEFINITION:

Retarding, arresting, or restraining.

indomethacin

DEFINITION:

A nonsteroidal anti-inflammatory agent; used in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

antidiuretic

DEFINITION:

1. Suppressing the rate of urine formation.

2. An agent that suppresses urine formation.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

indomethacin

DEFINITION:

A nonsteroidal anti-inflammatory agent; used in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

inhibiting

DEFINITION:

Retarding, arresting, or restraining.

inhibiting

DEFINITION:

Retarding, arresting, or restraining.

indomethacin

DEFINITION:

A nonsteroidal anti-inflammatory agent; used in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

inhibits

DEFINITION:

See definition under "inhibit."

enzyme

DEFINITION:

Any of numerous proteins that are produced by living cells and catalyze specific biochemical reactions at body temperatures.

phosphodiesterase

DEFINITION:

A term used in the recommended names of some phosphoric diester hydrolases of the hydrolase class that catalyze the hydrolysis of one of the two ester linkages in a phosphodiester compound.

antidiuretic

DEFINITION:

1. Suppressing the rate of urine formation.

2. An agent that suppresses urine formation.

indomethacin

DEFINITION:

A nonsteroidal anti-inflammatory agent; used in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

prostaglandin

DEFINITION:

Any of a group of components derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway; they are potent mediators of numerous different physiologic processes. The abbreviation for prostaglandin is PG; specific compounds are designated by adding a letter to indicate the type of ring structure and a numerical subscript to indicate the number of double bonds in the hydrocarbon skeleton (e.g., PGE₂, etc.). Most naturally occurring prostaglandins have two double bonds and are synthesized from arachidonic acid. The 1 series and 3 series are produced by the same pathway starting with fatty acids that have one fewer or one more double bond than arachidonic acid. The subscript a or ß indicates the three-dimensional configuration of alcoholic groups attached to the ring structures (a denotes a substituent below the plane of the ring, ß, above the plane). The naturally occurring PGF's all have the a configuration. Prostaglandins act in the cells in which they are synthesized and surrounding cells, and their actions and effects vary with concentration, hormonal environment, and cell type.

inhibition

DEFINITION:

Arrest or restraint of a process.

antidiuretic

DEFINITION:

1. Suppressing the rate of urine formation.

2. An agent that suppresses urine formation.

indomethacin

DEFINITION:

A nonsteroidal anti-inflammatory agent; used in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

prostaglandin

DEFINITION:

Any of a group of components derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway; they are potent mediators of numerous different physiologic processes. The abbreviation for prostaglandin is PG; specific compounds are designated by adding a letter to indicate the type of ring structure and a numerical subscript to indicate the number of double bonds in the hydrocarbon skeleton (e.g., PGE₂, etc.). Most naturally occurring prostaglandins have two double bonds and are synthesized from arachidonic acid. The 1 series and 3 series are produced by the same pathway starting with fatty acids that have one fewer or one more double bond than arachidonic acid. The subscript a or ß indicates the three-dimensional configuration of alcoholic groups attached to the ring structures (a denotes a substituent below the plane of the ring, ß, above the plane). The naturally occurring PGF's all have the a configuration. Prostaglandins act in the cells in which they are synthesized and surrounding cells, and their actions and effects vary with concentration, hormonal environment, and cell type.

inhibition

DEFINITION:

Arrest or restraint of a process.

prostaglandin

DEFINITION:

Any of a group of components derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway; they are potent mediators of numerous different physiologic processes. The abbreviation for prostaglandin is PG; specific compounds are designated by adding a letter to indicate the type of ring structure and a numerical subscript to indicate the number of double bonds in the hydrocarbon skeleton (e.g., PGE₂, etc.). Most naturally occurring prostaglandins have two double bonds and are synthesized from arachidonic acid. The 1 series and 3 series are produced by the same pathway starting with fatty acids that have one fewer or one more double bond than arachidonic acid. The subscript a or ß indicates the three-dimensional configuration of alcoholic groups attached to the ring structures (a denotes a substituent below the plane of the ring, ß, above the plane). The naturally occurring PGF's all have the a configuration. Prostaglandins act in the cells in which they are synthesized and surrounding cells, and their actions and effects vary with concentration, hormonal environment, and cell type.

inhibition

DEFINITION:

Arrest or restraint of a process.