Lithium-induced nephrogenic diabetes insipidus in older people.
| Title: | Lithium-induced nephrogenic diabetes insipidus in older people. |
|---|---|
| Authors: | Mukhopadhyay, D; Gokulkrishnan, L; Mohanaruban, K |
| Publisher: | Age Ageing |
| Date Published: | July 01, 2001 |
| Reference Number: | 518 |
PRESENTATION: We report two patients. The first is a 68-year-old woman who presented with a 2-day history of vomiting. She was hypernatraemic and her elevated serum sodium concentration did not improve initially, despite adequate fluid replacement. She subsequently developed polyuria and polydipsia. The second patient, a 77-year-old woman, presented with delirium and severe hypernatraemia after being treated for a chest infection 1 week earlier. Both patients were on long-term lithium treatment. INVESTIGATION: In both the cases, a supervised water-deprivation test done after normalization of the blood biochemistry showed partial nephrogenic diabetes insipidus. OUTCOME: Lithium was discontinued. CONCLUSION: Older people on lithium-especially those requiring supportive care-are at risk of severe hypernatraemia after an acute illness or if their fluid intake is restricted.
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