molecular

DEFINITION:

Of, pertaining to, or composed of molecules.

methodologies

DEFINITION:

See methodology .

integrative

DEFINITION:

See integration .

renal

DEFINITION:

Pertaining to the kidney.

physiology

DEFINITION:

1. The science which treats of the functions of the living organism and its parts, and of the physical and chemical factors and processes involved.

2. The basic processes underlying the functioning of a species or class of organism, or any of its parts or processes.

regulation

DEFINITION:

1. The act of adjusting or state or being adjusted to a certain standard.
2. In biology, the adaptation of form or behavior of an organism to changed conditions.
3. The power to form a whole embryo from stages before the gastrula.

kidney

DEFINITION:

One of a pair of vertebrate organs situated in the body cavity near the spinal column that excrete waste products of metabolism, in man are bean-shaped organs about 4-1/2 inches long lying behind the peritoneum in a mass of fatty tissue, and consist chiefly of nephrons by which urine is secreted, collected, and discharged into a main cavity whence it is conveyed by the ureter to the bladder.

concomitant

DEFINITION:

Accompanying; accessory; joined with another.

concentration

DEFINITION:

1. Increase in strength by evaporation.

2. The ratio of the mass or volume of a solute to the mass or volume of the solution or solvent.

solutes

DEFINITION:

Substances dissolved in a solvent; a solution consists of a solute and a solvent.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

renal

DEFINITION:

Pertaining to the kidney.

physiology

DEFINITION:

1. The science which treats of the functions of the living organism and its parts, and of the physical and chemical factors and processes involved.

2. The basic processes underlying the functioning of a species or class of organism, or any of its parts or processes.

cloning

DEFINITION:

The formation of a clone.

transporters

DEFINITION:

Transport proteins; often specifically a transport protein that after binding one to several molecules of substrate, undergoes a conformational change that moves only the substrate across the membrane. Different types facilitate movement with (symport) and against (antiport) concentration gradients.

receptors

DEFINITION:

See definitions under "receptor."

renal medulla

DEFINITION:

The inner part of the substance of the kidney, composed chiefly of collecting tubule elements, loops of Henle, and vasa recta, organized grossly into pyramids.

renal

DEFINITION:

Pertaining to the kidney.

medullary

DEFINITION:

Pertaining to the marrow or to any medulla; resembling marrow.

transporters

DEFINITION:

Transport proteins; often specifically a transport protein that after binding one to several molecules of substrate, undergoes a conformational change that moves only the substrate across the membrane. Different types facilitate movement with (symport) and against (antiport) concentration gradients.

aquaporin water channels

DEFINITION:

A family of membrane channel proteins that serve as selective pores through which water crosses the plasma membranes of many human tissues and cell types.

mediate

DEFINITION:

Indirect; accomplished by the aid of an intervening medium.

osmotic water transport

DEFINITION:

The movement of water through a semipermeable membrane (as of a living cell) into a solution of higher solute concentration that tends to equalize the concentrations of solute on the two sides of the membrane.

renal

DEFINITION:

Pertaining to the kidney.

medullary

DEFINITION:

Pertaining to the marrow or to any medulla; resembling marrow.

epithelia

DEFINITION:

Plural of epithelium .

water channels

DEFINITION:

Channels in a cell membrane that permit passage of water molecules; chemical substances such as vasopressin cause the opening of new channels and increase permeability.

aquaporin-2

DEFINITION:

Also called WCH-CD, this water channel makes the principal cells of the inner medullary collecting duct in the kidneys more permeable to water. Lack of functional aquaporin-2 gene leads to a rare form of nephrogenic diabetes insipidus.

regulation

DEFINITION:

1. The act of adjusting or state or being adjusted to a certain standard.
2. In biology, the adaptation of form or behavior of an organism to changed conditions.
3. The power to form a whole embryo from stages before the gastrula.

collecting duct

DEFINITION:

See under duct.

water permeability

DEFINITION:

The property or state of being permeable to water.

vasopressin

DEFINITION:

1. One of two octapeptide hormones formed by the neuronal cells of the hypothalamic nuclei and stored in the posterior lobe of the pituitary gland (neurohypophysis), the other being oxytocin. It stimulates the contraction of the muscular tissue of the capillaries and arterioles, raising the blood pressure. It promotes contraction of the intestinal musculature and increases peristalsis, and also exerts some contractile influence on the uterus. It also has a specific effect on the epithelial cells of the distal portion of the uriniferous tubule, augmenting resorption of water independently of solutes, resulting in concentration of urine and dilution of blood serum. Its rate of secretion is regulated chiefly by the osmolarity of the plasma.

2. [USP], A pharmaceutical preparation of the same principle, prepared synthetically or obtained from the posterior pituitary of healthy domestic animals used for food by man; used mainly as an antidiuretic in the treatment of acute or chronic diabetes insipidus, administered intramuscularly as a test of hypothalamo-neurohypophysial-renal function in distinguishing central from nephrogenic diabetes insipidus; it may also be used to stimulate smooth muscle tissue, especially to induce vasoconstriction in the presence of hemorrhage. Called also antidiuretic hormone (ADH).

collecting duct

DEFINITION:

See under duct.

water channels

DEFINITION:

Channels in a cell membrane that permit passage of water molecules; chemical substances such as vasopressin cause the opening of new channels and increase permeability.

aquaporin-2

DEFINITION:

Also called WCH-CD, this water channel makes the principal cells of the inner medullary collecting duct in the kidneys more permeable to water. Lack of functional aquaporin-2 gene leads to a rare form of nephrogenic diabetes insipidus.

aquaporin-3

DEFINITION:

A water channel in a cell membrane. This is the only water channel which allows anything but water to pass through its channel; urea and glycerol use it as well. (Adapted from: DP - JTRAN-3)

regulation

DEFINITION:

1. The act of adjusting or state or being adjusted to a certain standard.
2. In biology, the adaptation of form or behavior of an organism to changed conditions.
3. The power to form a whole embryo from stages before the gastrula.

vasopressin

DEFINITION:

1. One of two octapeptide hormones formed by the neuronal cells of the hypothalamic nuclei and stored in the posterior lobe of the pituitary gland (neurohypophysis), the other being oxytocin. It stimulates the contraction of the muscular tissue of the capillaries and arterioles, raising the blood pressure. It promotes contraction of the intestinal musculature and increases peristalsis, and also exerts some contractile influence on the uterus. It also has a specific effect on the epithelial cells of the distal portion of the uriniferous tubule, augmenting resorption of water independently of solutes, resulting in concentration of urine and dilution of blood serum. Its rate of secretion is regulated chiefly by the osmolarity of the plasma.

2. [USP], A pharmaceutical preparation of the same principle, prepared synthetically or obtained from the posterior pituitary of healthy domestic animals used for food by man; used mainly as an antidiuretic in the treatment of acute or chronic diabetes insipidus, administered intramuscularly as a test of hypothalamo-neurohypophysial-renal function in distinguishing central from nephrogenic diabetes insipidus; it may also be used to stimulate smooth muscle tissue, especially to induce vasoconstriction in the presence of hemorrhage. Called also antidiuretic hormone (ADH).

water channel proteins

DEFINITION:

See aquaporins.

regulation

DEFINITION:

1. The act of adjusting or state or being adjusted to a certain standard.
2. In biology, the adaptation of form or behavior of an organism to changed conditions.
3. The power to form a whole embryo from stages before the gastrula.

water channels

DEFINITION:

Channels in a cell membrane that permit passage of water molecules; chemical substances such as vasopressin cause the opening of new channels and increase permeability.

vasopressin

DEFINITION:

1. One of two octapeptide hormones formed by the neuronal cells of the hypothalamic nuclei and stored in the posterior lobe of the pituitary gland (neurohypophysis), the other being oxytocin. It stimulates the contraction of the muscular tissue of the capillaries and arterioles, raising the blood pressure. It promotes contraction of the intestinal musculature and increases peristalsis, and also exerts some contractile influence on the uterus. It also has a specific effect on the epithelial cells of the distal portion of the uriniferous tubule, augmenting resorption of water independently of solutes, resulting in concentration of urine and dilution of blood serum. Its rate of secretion is regulated chiefly by the osmolarity of the plasma.

2. [USP], A pharmaceutical preparation of the same principle, prepared synthetically or obtained from the posterior pituitary of healthy domestic animals used for food by man; used mainly as an antidiuretic in the treatment of acute or chronic diabetes insipidus, administered intramuscularly as a test of hypothalamo-neurohypophysial-renal function in distinguishing central from nephrogenic diabetes insipidus; it may also be used to stimulate smooth muscle tissue, especially to induce vasoconstriction in the presence of hemorrhage. Called also antidiuretic hormone (ADH).