arginine vasopressin

DEFINITION:

Vasopressin containing arginine, as that from most mammals, including man.

AVP

DEFINITION:

Arginine vasopressin.

mediated

DEFINITION:

Accomplished by the aid of an intervening medium.

receptor

DEFINITION:

1. A molecular structure within a cell or on the surface characterized by (1) selective binding of a specific substance and (2) a specific physiologic effect that accompanies the binding, e.g., membrane receptors for peptide hormones, neurotransmitters, antigens, complement fragments, and immunoglobulins and nuclear receptors for steroid hormones.

2. A sensory nerve terminal that responds to stimuli of various kinds; classified in various ways including by the type of stimulus and by the location in the body.

V2 receptor - The structure to which the antidiuretic hormone, arginine vasopressin binds.

receptors

DEFINITION:

See definitions under "receptor."

V2 receptor

DEFINITION:

See under receptor .

adenylyl cyclase

DEFINITION:

A membrane-bound enzyme that catalyzes the formation of cyclic AMP from ATP. An important component of some intracellular signaling pathways.

encoding

DEFINITION:

The process of converting (as a body of information) from one system of communication into another; esp.: to convert (a message) into code.

variability

DEFINITION:

The state of being variable.

cDNA

DEFINITION:

Complementary DNA or copy DNA.

gene

DEFINITION:

A segment of a DNA molecule that contains all the information required for synthesis of a product (polypeptide chain or RNA molecule), including both coding and non-coding sequences. It is the biological unit of heredity, self-reproducing, and transmitted from parent to progeny. Each gene has a specific position (locus) on the chromosome map. From the standpoint of function, genes are conceived of as structural, operator, and regulatory genes.

wild-type gene - The normal allele of a gene, sometimes symbolized by +.

X-linked gene - A gene carried on the X chromosome; the corresponding trait, whether dominant or recessive, is always expressed in males, who have only one X chromosome. X linkage is used sometimes synonymously with sex linkage since no genetic disorders have as yet been associated with genes on the Y chromosome.

encoding

DEFINITION:

The process of converting (as a body of information) from one system of communication into another; esp.: to convert (a message) into code.

V2 receptor

DEFINITION:

See under receptor .

mutations

DEFINITION:

1. Changes in form, quality, or some other characteristic.

X-linked nephrogenic diabetes insipidus

DEFINITION:

A form of diabetes insipidus, inherited as an X-linked trait, caused by failure of the renal tubules to reabsorb water in response to antidiuretic hormone, without disturbance in the renal filtration and solute excretion rates; the condition does not respond to exogenous vasopressin.

mutations

DEFINITION:

1. Changes in form, quality, or some other characteristic.

AVP

DEFINITION:

Arginine vasopressin.

pituitary

DEFINITION:

1. Hypophysial.
2. Hypophysis.
3. A preparation of some part of the pituitary gland of animals (e.g., cattle, pigs, sheep), used therapeutically.

diabetes insipidus

DEFINITION:

A disorder of the pituitary gland characterized by intense thirst and by the excretion of large amounts of urine.

diabetes insipidus, central - A metabolic disorder due to injury of the neurohypophyseal system, which results in a deficient quantity of antidiuretic hormone being released or produced, and thus in failure of tubular reabsorption of water in the kidney. As a result, a large amount of urine of low specific gravity is excreted, followed by dehydration and great thirst; it is often attended by voracious appetite, loss of strength, and emaciation. It may be inherited, acquired, or idiopathic.

diabetes insipidus, nephrogenic - A syndrome of polyuria and hyposthenuria caused by the failure of the renal tubules to reabsorb water in response to antidiuretic hormone, without disturbance in the renal filtration and solute excretion rates; the condition does not respond to exogenous vasopressin. It may be inherited as a rare X-linked trait or be acquired as a result of drug therapy or systemic disease.

diabetes insipidus, pituitary - Central diabetes insipidus (See above).

manifestation

DEFINITION:

Evidence or indication.

physiological

DEFINITION:

1. Of or pertaining to physiology.
2. Characteristic of or appropriate to an organism's healthy or normal functioning.
3. Differing in, involving, or affecting physiological factors.

AVP

DEFINITION:

Arginine vasopressin.

blood pressure

DEFINITION:

1. The pressure of blood against the walls of any blood vessel.

2. The pressure of the blood on the walls of the arteries, dependent on the energy of the heart action, the elasticity of the walls of the arteries, and the volume and viscosity of the blood. The maximum or systolic blood pressure occurs near the end of the stroke output of the left ventricle of the heart. The minimum or diastolic blood pressure occurs late in ventricular diastole. Mean blood pressure is the average of the blood pressure levels, and basic blood pressure is that during quiet rest or basal conditions. See also hypertension and hypotension.