association

DEFINITION:

1. A state in which two attributes occur together either more or less often than expected by chance.

2. In neurology, a term applied to those regions of the brain that link the primary motor and sensory cortices; see association areas.

3. In genetics, the occurrence together of two or more phenotypic characteristics more often than would be expected by chance.

4. In psychiatry, a connection between ideas or feelings, especially between conscious thoughts and elements of the unconscious, or the formation of such a connection.

expression

DEFINITION:

1. The aspect or appearance of the face (or surface of a cell) as determined by the physical or emotional state.

2. The act of squeezing or evacuating by pressure; a term used in pharmacy, surgery, and obstetrics.

3. The detectable effect of a gene.

4. A representation of value, relation, or the like (e.g., ratio).

sodium

DEFINITION:

A silver white soft waxy ductile element of the alkali metal group that occurs abundantly in nature in combined form and is very active chemically.

transporter

DEFINITION:

A transport protein; often specifically a transport protein that after binding one to several molecules of substrate, undergoes a conformational change that moves only the substrate across the membrane. Different types facilitate movement with (symport) and against (antiport) concentration gradients.

rBSC

DEFINITION:

Rat bumetanide sensitive cotransporter (See JAB-670).

thick ascending limb of Henle

DEFINITION:

See "loop of Henle."

urinary concentration

DEFINITION:

The increase in strength of urine by evaporation.

association

DEFINITION:

1. A state in which two attributes occur together either more or less often than expected by chance.

2. In neurology, a term applied to those regions of the brain that link the primary motor and sensory cortices; see association areas.

3. In genetics, the occurrence together of two or more phenotypic characteristics more often than would be expected by chance.

4. In psychiatry, a connection between ideas or feelings, especially between conscious thoughts and elements of the unconscious, or the formation of such a connection.

expression

DEFINITION:

1. The aspect or appearance of the face (or surface of a cell) as determined by the physical or emotional state.

2. The act of squeezing or evacuating by pressure; a term used in pharmacy, surgery, and obstetrics.

3. The detectable effect of a gene.

4. A representation of value, relation, or the like (e.g., ratio).

elucidated

DEFINITION:

Made lucid (clear) especially by explanation or analysis; to give a clarifying explanation.

G

DEFINITION:

As G - Symbol for "gauss," "giga-," "gravida," and "guanine" or "guanosine."

body weight

DEFINITION:

Heaviness; the degree to which a body is drawn toward the earth by gravity.

AVP

DEFINITION:

Arginine vasopressin.

BB rats

DEFINITION:

Brattleboro rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

concentrated

DEFINITION:

1. Brought to a common center; gathered together at one point.

2. Having increased the strength by diminishing the bulk of, as of a liquid; condensed.

3. A drug or other preparation that has been strengthened by the evaporation of its non-active parts.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

mean

DEFINITION:

1. An average; a number that in some sense represents the central value of a set of numbers.
2. Arithmetic mean.
3. In probability and statistics, the expected value (mathematical expectation) of a random variable, the limiting value to which the sample mean converges as the sample size is increased indefinitely (if the limit exists).

SD

DEFINITION:

Abbreviation for skin dose; standard deviation.

baseline

DEFINITION:

An observation or value that represents the normal background level, or an initial level, of a measurable quantity; used for comparison with values representing response to experimental intervention or an environmental stimulus, usually implying that the baseline and response values refer to the same individual or system.

sodium

DEFINITION:

A silver white soft waxy ductile element of the alkali metal group that occurs abundantly in nature in combined form and is very active chemically.

urea

DEFINITION:

A soluble weakly basic nitrogenous compound CO(NH₂)₂ that is the chief solid component of mammalian urine and an end product of protein decomposition, is synthesized from carbon dioxide and ammonia, and is used especially in synthesis (as of resins and plastics) and in fertilizers and animal rations.

renal medulla

DEFINITION:

The inner part of the substance of the kidney, composed chiefly of collecting tubule elements, loops of Henle, and vasa recta, organized grossly into pyramids.

mRNA

DEFINITION:

Messenger RNA. RNA molecules, usually 400 to 10,000 bases long, that serve as templates for protein synthesis (translation); in eukaryotes they have characteristic posttranscriptional modifications, the 5'-cap and poly A tail. The base sequence of an mRNA transcript completely specifies the corresponding polypeptide amino acid sequence.

protein

DEFINITION:

Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen, and which are widely distributed in plants and animals. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique, genetically defined amino acid sequence which determines its specific shape and function. They serve as enzymes, structural elements, hormones, immunoglobulins, etc., and are involved in oxygen transport, muscle contraction, electron transport, and other activities throughout the body, and in photosynthesis.

binding protein - any of a number of plasma proteins (See below) that bind to hormones of low solubility (chiefly the thyroid and steroid hormones), thus providing a transport system for them; some are specific for particular hormones, while others bind to any sparingly soluble hormones. Called also carrier protein or transport protein (See below).

carrier proteins - A binding protein (See above).

plasma proteins - The hundreds of different proteins present in blood plasma, including carrier proteins (such as albumin, transferrin, and haptoglobin), fibrinogen and other coagulation factors, complement components, immunoglobulins, enzyme inhibitors, precursors of substances such as angiotensin and bradykinin, and many other types of proteins.

transport protein - binding protein (See above).

aquaporin

DEFINITION:

A family of membrane channel proteins that serve as selective pores through which water crosses the plasma membranes of many human tissues and cell types.

AQP2

DEFINITION:

Aquaporin-2.

expression

DEFINITION:

1. The aspect or appearance of the face (or surface of a cell) as determined by the physical or emotional state.

2. The act of squeezing or evacuating by pressure; a term used in pharmacy, surgery, and obstetrics.

3. The detectable effect of a gene.

4. A representation of value, relation, or the like (e.g., ratio).

BB rats

DEFINITION:

Brattleboro rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

subcutaneous

DEFINITION:

Beneath the skin.

infusion

DEFINITION:

1. The steeping of a substance in water to obtain its medicinal principles.

2. The product of the process of steeping a drug for extraction of its medicinal principles.

3. The therapeutic introduction of a fluid other than blood, as saline solution, into a vein.

NOTE---An infusion flows in by gravity, an injection is forced in by a syringe, an instillation is dropped in, an insufflation is blown in, and an infection slips in unnoticed.

desmopressin acetate

DEFINITION:

A potent synthetic analogue of vasopressin, used intranasally, intramuscularly, or intravenously as an antidiuretic in pituitary diabetes insipidus and intravenously to increase coagulation factor VIII activity before surgical procedures in patients with hemophilia and von Willebrand's disease.

dDAVP

DEFINITION:

Also DDAVP. Trademark for preparation of desmopressin.

BB rats

DEFINITION:

Brattleboro rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

expression

DEFINITION:

1. The aspect or appearance of the face (or surface of a cell) as determined by the physical or emotional state.

2. The act of squeezing or evacuating by pressure; a term used in pharmacy, surgery, and obstetrics.

3. The detectable effect of a gene.

4. A representation of value, relation, or the like (e.g., ratio).

countercurrent multiplication

DEFINITION:

The mechanism in the loops of Henle of the renal tubules by which urine is concentrated; it is dependent upon unique solute transport processes at different parts of the loops of Henle and the vasa recta.

AVP

DEFINITION:

Arginine vasopressin.

association

DEFINITION:

1. A state in which two attributes occur together either more or less often than expected by chance.

2. In neurology, a term applied to those regions of the brain that link the primary motor and sensory cortices; see association areas.

3. In genetics, the occurrence together of two or more phenotypic characteristics more often than would be expected by chance.

4. In psychiatry, a connection between ideas or feelings, especially between conscious thoughts and elements of the unconscious, or the formation of such a connection.

expression

DEFINITION:

1. The aspect or appearance of the face (or surface of a cell) as determined by the physical or emotional state.

2. The act of squeezing or evacuating by pressure; a term used in pharmacy, surgery, and obstetrics.

3. The detectable effect of a gene.

4. A representation of value, relation, or the like (e.g., ratio).

urinary concentration

DEFINITION:

The increase in strength of urine by evaporation.

AVP

DEFINITION:

Arginine vasopressin.

hormone

DEFINITION:

A product of living cells that circulates in body fluids and produces a specific effect on the activity of cells remote from its point of origin; especially: one exerting a stimulatory effect on a cellular activity.

hypophysiotropic hormones - Hormones produced by the hypothalamus, usually releasing hormones (see below), which maintain the endocrine functions of cells of the adenohypophysis.

neurohormone - A hormone secreted by a specialized neuron into the bloodstream, the cerebrospinal fluid, or the intercellular spaces of the nervous system.

releasing hormones - Hormones elaborated in one structure that cause the release of hormones from another structure, such as those from the hypothalamus that act on the adenohypophysis. The term is applied to substances of established chemical identity, whereas substances of unknown chemical structure are called releasing factors .

arginine vasopressin

DEFINITION:

Vasopressin containing arginine, as that from most mammals, including man.

AVP

DEFINITION:

Arginine vasopressin.

binds

DEFINITION:

1. To wrap with a binder or bandage.

2. To form a weak, reversible chemical bond, e.g., antigen to antibody or hormone to receptor.

receptor

DEFINITION:

1. A molecular structure within a cell or on the surface characterized by (1) selective binding of a specific substance and (2) a specific physiologic effect that accompanies the binding, e.g., membrane receptors for peptide hormones, neurotransmitters, antigens, complement fragments, and immunoglobulins and nuclear receptors for steroid hormones.

2. A sensory nerve terminal that responds to stimuli of various kinds; classified in various ways including by the type of stimulus and by the location in the body.

V2 receptor - The structure to which the antidiuretic hormone, arginine vasopressin binds.

vasopressin 2 receptor

DEFINITION:

The molecular structure within a cell or on the surface to which the antidiuretic hormone, arginine vasopressin, binds.

V2R

DEFINITION:

Vasopressin-2 receptor.

principal cells

DEFINITION:

1. The fundamental cells of an organ, which usually have a specific function.

2. The principal cells are the chief cells, i.e., the most abundant cells of the parathyroid glands, being polygonal epithelial cells with a granular cytoplasm and vesicular nuclei, arranged in plates or cords, and which are rich in glycogen: the clear cells are more numerous and have relatively large nuclei and clear cytoplasm with few granules, while the dark cells are smaller with smaller and darker nuclei and finely granular cytoplasm with many granules. Intermediate forms also exist.

kidney collecting duct

DEFINITION:

Also known as the tubulus renalis colligens , or renal collecting tubule: that structure of the kidney consisting of the arcuate renal tubule, straight collecting tubule, and papillary duct considered together.

kidney

DEFINITION:

One of a pair of vertebrate organs situated in the body cavity near the spinal column that excrete waste products of metabolism, in man are bean-shaped organs about 4-1/2 inches long lying behind the peritoneum in a mass of fatty tissue, and consist chiefly of nephrons by which urine is secreted, collected, and discharged into a main cavity whence it is conveyed by the ureter to the bladder.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

countercurrent multiplication

DEFINITION:

The mechanism in the loops of Henle of the renal tubules by which urine is concentrated; it is dependent upon unique solute transport processes at different parts of the loops of Henle and the vasa recta.

transport

DEFINITION:

The movement of materials in biological systems, particularly into and out of cells and across epithelial layers.

solutes

DEFINITION:

Substances dissolved in a solvent; a solution consists of a solute and a solvent.

sodium

DEFINITION:

A silver white soft waxy ductile element of the alkali metal group that occurs abundantly in nature in combined form and is very active chemically.

kidney

DEFINITION:

One of a pair of vertebrate organs situated in the body cavity near the spinal column that excrete waste products of metabolism, in man are bean-shaped organs about 4-1/2 inches long lying behind the peritoneum in a mass of fatty tissue, and consist chiefly of nephrons by which urine is secreted, collected, and discharged into a main cavity whence it is conveyed by the ureter to the bladder.

loops of Henle

DEFINITION:

Henle's loop - The long, U-shaped part of the renal tubule, extending through the medulla from the end of the proximal convoluted tubule to the beginning of the distal convoluted tubule. It begins with a descending limb having a thick-walled segment called the proximal straight tubule , followed by a thin-walled segment called the thin or attenuated tubule ; this is followed by the ascending limb , which sometimes includes the distal end of the attenuated tubule and always ends with a long thick-walled segment called the distal straight tubule . The loops vary in the lengths of their segments according to their locations in the kidney. Called also ansa nephroni .

vasa recta

DEFINITION:

See "arteriolae rectae renis."

Brattleboro rats

DEFINITION:

Also known as BB rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

association

DEFINITION:

1. A state in which two attributes occur together either more or less often than expected by chance.

2. In neurology, a term applied to those regions of the brain that link the primary motor and sensory cortices; see association areas.

3. In genetics, the occurrence together of two or more phenotypic characteristics more often than would be expected by chance.

4. In psychiatry, a connection between ideas or feelings, especially between conscious thoughts and elements of the unconscious, or the formation of such a connection.

expression

DEFINITION:

1. The aspect or appearance of the face (or surface of a cell) as determined by the physical or emotional state.

2. The act of squeezing or evacuating by pressure; a term used in pharmacy, surgery, and obstetrics.

3. The detectable effect of a gene.

4. A representation of value, relation, or the like (e.g., ratio).

sodium

DEFINITION:

A silver white soft waxy ductile element of the alkali metal group that occurs abundantly in nature in combined form and is very active chemically.

transporter

DEFINITION:

A transport protein; often specifically a transport protein that after binding one to several molecules of substrate, undergoes a conformational change that moves only the substrate across the membrane. Different types facilitate movement with (symport) and against (antiport) concentration gradients.

CO

DEFINITION:

Cardiac output.

transporter

DEFINITION:

A transport protein; often specifically a transport protein that after binding one to several molecules of substrate, undergoes a conformational change that moves only the substrate across the membrane. Different types facilitate movement with (symport) and against (antiport) concentration gradients.

rBSC

DEFINITION:

Rat bumetanide sensitive cotransporter (See JAB-670).

thick ascending limb of Henle

DEFINITION:

See "loop of Henle."

loops of Henle

DEFINITION:

Henle's loop - The long, U-shaped part of the renal tubule, extending through the medulla from the end of the proximal convoluted tubule to the beginning of the distal convoluted tubule. It begins with a descending limb having a thick-walled segment called the proximal straight tubule , followed by a thin-walled segment called the thin or attenuated tubule ; this is followed by the ascending limb , which sometimes includes the distal end of the attenuated tubule and always ends with a long thick-walled segment called the distal straight tubule . The loops vary in the lengths of their segments according to their locations in the kidney. Called also ansa nephroni .

urinary concentration

DEFINITION:

The increase in strength of urine by evaporation.

sodium chloride

DEFINITION:

Common table salt: a mineral soluble in water and found widely distributed over the earth, such as in sea water. It is a necessary constituent of the body and consequently of the diet, making up over 90 percent of the inorganic constituents of the blood serum, and is the principal salt involved in maintaining osmotic tension of blood and tissues. It is used in medicine [USP] for many purposes, such as in the preparation of isotonic and physiologic saline solutions; as a fluid and electrolyte replenisher; as an isotonic vehicle for drugs; as an antihypercalcemic; as an antidote to silver nitrate poisoning, administered by intravenous infusion; as a topical antiinflammatory; to irrigate wounds and body cavities; as an enema to flush the colon and promote evacuation; as a mucolytic, administered by inhalation; as a topical osmotic agent in ophthalmology. Also used widely as a food preservative and seasoning.

NaCl

DEFINITION:

Sodium chloride.

osmotic

DEFINITION:

Of, relating to, or having the properties of osmosis.

aquaporin 2

DEFINITION:

Also called WCH-CD, this water channel makes the principal cells of the inner medullary collecting duct in the kidneys more permeable to water. Lack of functional aquaporin-2 gene leads to a rare form of nephrogenic diabetes insipidus.

AQP2

DEFINITION:

Aquaporin-2.

AQP2

DEFINITION:

Aquaporin-2.

AVP

DEFINITION:

Arginine vasopressin.

BB rats

DEFINITION:

Brattleboro rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

synthesize

DEFINITION:

To produce by means of synthesis.

AVP

DEFINITION:

Arginine vasopressin.

concentrate

DEFINITION:

1. To bring to a common center; to gather together at one point.

2. To increase the strength by diminishing the bulk of, as of a liquid; to condense.

3. A drug or other preparation that has been strengthened by the evaporation of its non-active parts.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

BB rats

DEFINITION:

Brattleboro rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

capacity

DEFINITION:

1. Power or ability to hold, retain, or contain, or the ability to absorb.

2. The volume or potential volume of material (solid, liquid, or gas) that can be held or contained.

3. Capacitance.

4. Mental ability to receive, accomplish, endure, or understand.

concentrate

DEFINITION:

1. To bring to a common center; to gather together at one point.

2. To increase the strength by diminishing the bulk of, as of a liquid; to condense.

3. A drug or other preparation that has been strengthened by the evaporation of its non-active parts.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

expressed

DEFINITION:

1. Showing a detectable effect of a gene.

2. Made known; shown.

3. Squeezed out; extracted by pressing.

AVP

DEFINITION:

Arginine vasopressin.

stimuli

DEFINITION:

Plural of stimulus .

BB rats

DEFINITION:

Brattleboro rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

body weight

DEFINITION:

Heaviness; the degree to which a body is drawn toward the earth by gravity.

AVP

DEFINITION:

Arginine vasopressin.

concentrate

DEFINITION:

1. To bring to a common center; to gather together at one point.

2. To increase the strength by diminishing the bulk of, as of a liquid; to condense.

3. A drug or other preparation that has been strengthened by the evaporation of its non-active parts.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

sodium

DEFINITION:

A silver white soft waxy ductile element of the alkali metal group that occurs abundantly in nature in combined form and is very active chemically.

urea

DEFINITION:

A soluble weakly basic nitrogenous compound CO(NH₂)₂ that is the chief solid component of mammalian urine and an end product of protein decomposition, is synthesized from carbon dioxide and ammonia, and is used especially in synthesis (as of resins and plastics) and in fertilizers and animal rations.

kidney medulla

DEFINITION:

See "renal medulla."

sodium

DEFINITION:

A silver white soft waxy ductile element of the alkali metal group that occurs abundantly in nature in combined form and is very active chemically.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

AQP2

DEFINITION:

Aquaporin-2.

AQP2 expression

DEFINITION:

The process, or the regulation of the process, by which the effects of the aquaporin-2 gene are manifested.

urinary concentration

DEFINITION:

The increase in strength of urine by evaporation.

BB rats

DEFINITION:

Brattleboro rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

expression

DEFINITION:

1. The aspect or appearance of the face (or surface of a cell) as determined by the physical or emotional state.

2. The act of squeezing or evacuating by pressure; a term used in pharmacy, surgery, and obstetrics.

3. The detectable effect of a gene.

4. A representation of value, relation, or the like (e.g., ratio).

countercurrent multiplication

DEFINITION:

The mechanism in the loops of Henle of the renal tubules by which urine is concentrated; it is dependent upon unique solute transport processes at different parts of the loops of Henle and the vasa recta.

urinary concentration

DEFINITION:

The increase in strength of urine by evaporation.

AVP

DEFINITION:

Arginine vasopressin.

dDAVP

DEFINITION:

Also DDAVP. Trademark for preparation of desmopressin.

AQP2

DEFINITION:

Aquaporin-2.

AQP2

DEFINITION:

Aquaporin-2.

blocker

DEFINITION:

Something that obstructs passage or activity.

dDAVP

DEFINITION:

Also DDAVP. Trademark for preparation of desmopressin.

concentrate

DEFINITION:

1. To bring to a common center; to gather together at one point.

2. To increase the strength by diminishing the bulk of, as of a liquid; to condense.

3. A drug or other preparation that has been strengthened by the evaporation of its non-active parts.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

concentrate

DEFINITION:

1. To bring to a common center; to gather together at one point.

2. To increase the strength by diminishing the bulk of, as of a liquid; to condense.

3. A drug or other preparation that has been strengthened by the evaporation of its non-active parts.

urine

DEFINITION:

The fluid excreted by the kidneys, passed through the ureters, stored in the bladder, and discharged through the urethra. Urine, in health, has an amber color, a slight acid reaction, a peculiar odor, and a bitter, saline taste.

BB rats

DEFINITION:

Brattleboro rats, a strain that serves as a model of diabetes insipidus (L. Brown). Brattleboro rats have a mutation in the gene that codes for vasopressin and its sister protein neurophysin. Thus, they produce no vasopressin and can be said to have “central diabetes insipidus” (M. Knepper).

expression

DEFINITION:

1. The aspect or appearance of the face (or surface of a cell) as determined by the physical or emotional state.

2. The act of squeezing or evacuating by pressure; a term used in pharmacy, surgery, and obstetrics.

3. The detectable effect of a gene.

4. A representation of value, relation, or the like (e.g., ratio).

AVP

DEFINITION:

Arginine vasopressin.

urinary concentration

DEFINITION:

The increase in strength of urine by evaporation.

urinary concentration

DEFINITION:

The increase in strength of urine by evaporation.

countercurrent multiplication

DEFINITION:

The mechanism in the loops of Henle of the renal tubules by which urine is concentrated; it is dependent upon unique solute transport processes at different parts of the loops of Henle and the vasa recta.

AVP

DEFINITION:

Arginine vasopressin.