Aquaporins and Ion Conductance
| Title: | Aquaporins and Ion Conductance |
|---|---|
| Authors: | Mulders, Sabine M.; van Os, Carel; Deen, Peter M.T.; Kansen, S. M. |
| Publisher: | Science |
| Date Published: | March 07, 1997 |
| Reference Number: | 205 |
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This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. We concentrated our translation on those aspects of the article dealing directly with NDI. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder.
© Copyright NDI Foundation 2007 (JC)
Agre, et al., reported they found that AQP2 transports water, but does not conduct ions. Saschi, et al., tested AQP1 to see if it conducted ions. It did not. The tests of Verkman and Yang could not confirm Yool, et al's, finding of AQP1 as either a water or ion conductor. Verkman and Yang noted that oocyte viability and membrane permeabilities might be disturbed by having them express foreign membrane proteins (the AQP1) and treating them with cAMP as Yool did.
Deen, et al., stated they had not been able to detect the ability to conduct positively charged ions in either AQP0 or AQP1 when either is expressed in oocytes. But they had not exposed the aquaporins to cAMP or forskolin. When they exposed AQP1 expressed in oocytes to cAMP, it still did not conduct positively charged ions.
Fischbarg, et al., stated that their test results suggest that variability among batches of oocyte cell could result in different test results, as did Patil, et al. In reply, Yool, et al., state that the criteria used to select oocytes must be resolved. They also note that AQP1 and AQP2 can differ in their response to cAMP or forskolin.