laboratory
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- laboratory
-
A place equipped for performing experimental work or investigative procedures, for the preparation of drugs, chemicals, etc.
Used in 14 Article abstracts
Used in 14 Article abstracts
- Acquired Nephrogenic Diabetes Insipidus Secondary to Distal Renal Tubular Acidosis and Nephrocalcinosis Associated with Sjogren's Syndrome
- Amphotericin B-Induced Partial Nephrogenic Diabetes Insipidus in a Child
- Amphotericin B-induced Nephrogenic Diabetes Insipidus in a Case of Cryptococcemia
- Clinical Utility of Direct Mutation Testing for Congenital Nephrogenic Diabetes Insipidus in Families
- Compound Deletion of the rhoGAP C1 and V2 Vasopressin Receptor Genes in a Patient with Nephrogenic Diabetes Insipidus
- Lithium-Induced Nephrogenic Diabetes Insipidus Treated with Indomethacin
- Lithiumogenic Disorders of the Thyroid and Parathyroid Glands as Surgical Disease
- Molecular Analyses of the Vasopressin Type 2 Receptor and Aquaporin-2 Genes in Brazilian Kindreds with Nephrogenic Diabetes Insipidus
- Nephrogenic Diabetes Insipidus and Renal Tubular Acidosis Secondary to Foscarnet Therapy
- Polyuria and Polydipsia. Problems Associated with Patient Evaluation
- Polyuria in Childhood
- Role of Aquaporin Water Channels in Kidney and Lung
- Transient Nephrogenic Diabetes Insipidus Accompanied by Possible Psychogenic Polydipsia
- Two Novel Types of Contiguous Gene Deletion of the AVPR2 and ARHGAP4 Genes in Unrelated Japanese Kindreds with Nephrogenic Diabetes Insipidus
Used in 9 Article bodies
Used in 9 Article bodies
- Hereditary Vasopressin Resistance in Man and Mouse
- Index of Suspicion. Case 2. Nephrogenic Diabetes Insipidus
- Intracranial Calcification in Nephrogenic Diabetes Insipidus
- Lithium-Induced Nephrogenic Diabetes Insipidus Treated with Indomethacin
- Molecular Analysis of X-Linked Nephrogenic Diabetes Insipidus
- Nephrogenic Diabetes Insipidus
- Nephrogenic Diabetes Insipidus Secondary to Lithium Therapy in the Postoperative Patient: A Case Report
- Nephrogenic Diabetes Insipidus in a Patient Taking Cidofovir
- Nephrogenic Diabetes Insipidus--Prodromal Phase of Multiple Myeloma
Used in 97 Article translations
Used in 97 Article translations
- A Dileucine Sequence and an Upstream Glutamate Residue in the Intracellular Carboxyl Terminus of the Vasopressin V2 Receptor are Essential for Cell Surface Transport in COS.M6 Cells
- A Fully Active Nonglycosylated V2 Vasopressin Receptor
- A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial Cells
- A Low Affinity Vasopressin V2-Receptor in Inherited Nephrogenic Diabetes Insipidus
- A Low-Affinity Vasopressin V2-Receptor Gene in a Kindred with X-Linked Nephrogenic Diabetes Insipidus
- A Mouse Model to Test the in vivo Efficacy of Chemical Chaperones
- A Novel Mechanism in Recessive Nephrogenic Diabetes Insipidus: Wild-Type Aquaporin-2 Rescues the Apical Membrane Expression of Intracellularly Retained AQP2-P262L
- A Serine Cluster Prevents Recycling of the V2 Vasopressin Receptor
- Aminoglycoside Pretreatment Partially Restores the Function of Truncated V2 Vasopressin Receptors Found in Patients with Nephrogenic Diabetes Insipidus
- An Aquaporin-2 Water Channel Mutant Which Causes Autosomal Dominant Nephrogenic Diabetes Insipidus is Retained in the Golgi Complex
- An Impaired Routing of Wild-type Aquaporin-2 after Tetramerization with an Aquaporin-2 Mutant Explains Dominant Nephrogenic Diabetes Insipidus
- An X-linked NDI Mutation Reveals a Requirement for Cell Surface V2R Expression
- Angiotensin II Upregulates the Expression of Vasopressin V2 mRNA in the Inner Medullary Collecting Duct of the Rat
- Appropriate Polarization Following Pharmacological Rescue of V2 Vasopressin Receptors Encoded by X-Linked Nephrogenic Diabetes Insipidus Alleles Involves a Conformation of the Receptor That Also Attains Mature Glycosylation
- Aquaporin-2 Water Channel Mutations and Nephrogenic Diabetes Insipidus: New Variations on a Theme
- Bidirectional Regulation of AQP2 Trafficking and Recycling: Involvement of AQP2-S256 Phosphorylation
- Binding-, Intracellular Transport-, and Biosynthesis-Defective Mutants of Vasopressin Type 2 Receptor in Patients with X-Linked Nephrogenic Diabetes Insipidus
- Biochemical Basis of Partial Nephrogenic Diabetes Insipidus Phenotypes
- Cellular Distribution of the Aquaporins: A Family of Water Channel Proteins
- Characterization of Vasopressin V2 Receptor Mutants in Nephrogenic Diabetes Insipidus in a Polarized Cell Model
- Cloning of an Aquaporin Homologue Present in Water Channel Containing Endosomes of Toad Urinary Bladder
- Cloning, Characterization, and Chromosomal Mapping of Human Aquaporin of Collecting Duct
- Compartmentalization of cAMP-Dependent Signaling by Phosphodiesterase-4D is Involved in the Regulation of Vasopressin-Mediated Water Reabsorption in Renal Principal Cells
- Congenital Nephrogenic Diabetes Insipidus
- Constitutive and Regulated Membrane Expression of Aquaporin 1 and Aquaporin 2 Water Channels in Stably Transfected LLC-PK1 Epithelial Cells
- Cross Talk Between Stimulatory and Inhibitory Guanosine 5'-Triphosphate Binding Proteins: Role in Activation and Desensitization of the Adenylate Cyclase Response to Vasopressin
- Defective Aquaporin-2 Trafficking in Nephrogenic Diabetes Insipidus and Correction by Chemical Chaperones
- Development and Characterization of a Mouse Cell Line Expressing the Human V2 Vasopressin Receptor Gene
- Discovery of Aquaporins: a Breakthrough in Research on Renal Water Transport
- Dual Actions of Vasopressin and Oxytocin in Regulation of Water Permeability in Terminal Collecting Duct
- Evidence for Intact V1-vasopressin Receptors in Congenital Nephrogenic Diabetes Insipidus
- Expression Studies of Two Vasopressin V2 Receptor Gene Mutations, R202C and 804insG, in Nephrogenic Diabetes Insipidus
- Functional Analysis of Aquaporin-2 Mutants Associated with Nephrogenic Diabetes Insipidus by Yeast Expression
- Functional Involvement of VAMP/Synaptobrevin-2 in cAMP-Stimulated Aquaporin 2 Translocation in Renal Collecting Duct Cells
- Functional Role of the NPxxY Motif in Internalization of the Type 2 Vasopressin Receptor in LLC-PK1 Cells
- Functional Studies of Twelve Mutant V2 Vasopressin Receptors Related to Nephrogenic Diabetes Insipidus: Molecular Basis of a Mild Clinical Phenotype
- Hemifacial Spasm in Albright's Hereditary Osteodystrophy with Pseudopseudohypoparathyroidism and Nephrogenic Diabetes Insipidus--Case Report
- Heteroligomerization of an Aquaporin-2 Mutant with Wild-Type Aquaporin-2 and Their Misrouting to Late Endosomes/Lysosomes Explains Dominant Nephrogenic Diabetes Insipidus
- Hypertonicity Regulates the Aquaporin-2 Promoter Independently of Arginine Vasopressin
- Identification and Characterization of Aquaporin-2 Water Channel Mutations Causing Nephrogenic Diabetes Insipidus with Partial Vasopressin Response
- Identification of a Novel A-kinase Anchoring Protein 18 Isoform and Evidence for its Role in the Vasopressin-induced Aquaporin-2 Shuttle in Renal Principal Cells
- Importance of the Mercury-Sensitive Cysteine on Function and Routing of AQP1 and AQP2 in Oocytes
- Increased Renal Responsiveness to Vasopressin and Enhanced V2 Receptor Signaling in RGS2-/- Mice
- Induction of Intramembranous Particle Clusters in Mice with Nephrogenic Diabetes Insipidus
- Inhibition of Endocytosis Causes Phosphorylation (S256)-Independent Plasma Membrane Accumulation of AQP-2
- Insulin Potentiates AVP-induced AQP2 Expression in Cultured Renal Collecting Duct Principal Cells
- Intracranial Calcification in Nephrogenic Diabetes Insipidus
- Lithiumogenic Disorders of the Thyroid and Parathyroid Glands as Surgical Disease
- MAL Decreases the Internalization of the Aquaporin-2 Water Channel
- Maturation of Receptor Proteins in Eukaryotic Expression Systems
- Methyl-β-Cyclodextrin Induces Vasopressin-Independent Apical Accumulation of Aquaporin-2 in the Isolated, Perfused Rat Kidney
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular Analysis of X-Linked Nephrogenic Diabetes Insipidus
- Molecular Aspects of Vasopressin Receptor Function
- Molecular Genetic Study of Congenital Nephrogenic Diabetes Insipidus and Rescue of Mutant Vasopressin V2 Receptor by Chemical Chaperones
- Molecular Insights into the Pathogenesis of Inherited Renal Tubular Disorders
- N-ethylmaleimide (NEM) Causes Aquaporin-2 Trafficking in the Renal Inner Medullary Collecting Duct by Direct Activation of Protein Kinase A
- Nephrogenic Diabetes Insipidus and Renal Tubular Acidosis Secondary to Foscarnet Therapy
- Nephrogenic Diabetes Insipidus. A V2 Vasopressin Receptor Unable to Stimulate Adenylyl Cyclase
- Nephrogenic Diabetes Insipidus: Clinical Symptoms, Pathogenesis, Genetics and Treatment
- Nephrogenic Diabetes Insipidus: Identification of the Genetic Defect
- Novel Mutations in the V2 Vasopressin Receptor Gene in Two Pedigrees with Congenital Nephrogenic Diabetes Insipidus
- Osmolality and Solute Composition are Strong Regulators of AQP2 Expression in Renal Principal Cells
- Palmitoylation of the V2 Vasopressin Receptor
- Pathogenesis and Treatment of Autosomal-Dominant Nephrogenic Diabetes Insipidus Caused by an Aquaporin 2 Mutation
- Pathophysiology of Aquaporin-2 in Water Balance Disorders
- Patients with Autosomal Nephrogenic Diabetes Insipidus Homozygous for Mutations in the Aquaporin 2 Water-Channel Gene
- Pharmacochaperones Post-Translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-Type and Mutant Vasopressin V2 Receptors
- Pharmacologic Chaperones as a Potential Treatment for X-linked Nephrogenic Diabetes Insipidus
- Pharmacological Chaperones Rescue Cell-Surface Expression and Function of Misfolded V2 Vasopressin Receptor Mutants
- Pharmacological Chaperones: Potential Treatment for Conformational Diseases
- Properties of the Human Arginine Vasopressin V2 Receptor after Site-Directed Mutagenesis of its Putative Palmitoylation Site
- Rat Kidney Papilla Contains Abundant Synaptobrevin Protein that Participates in the Fusion of Antidiuretic Hormone-regulated Water Channel-containing Endosomes In Vitro
- Reconstitution of Mutant V2 Vasopressin Receptors by Adenovirus-mediated Gene Transfer
- Reconstitution of a Regulated Transepithelial Water Pathway in Cells Transfected with AQP2 and an AQP1/AQP2 Hybrid Containing the AQP2-C Terminus
- Regulation of V2 Vasopressin Receptor Degradation by Agonist Promoted Ubiquitination
- Renal Aquaporins
- Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-Dependent Concentration of Urine
- Rescue of a Nephrogenic Diabetes Insipidus-Causing Vasopressin V2 Receptor Mutant by Cell-Penetrating Peptides
- Reversed Polarized Delivery of an Aquaporin-2 Mutant Causes Dominant Nephrogenic Diabetes Insipidus
- Rho Inhibits cAMP-Induced Translocation of Aquaporin-2 into the Apical Membrane of Renal Cells
- Role of Aquaporin Water Channels in Kidney and Lung
- Short-Chain Ubiquitination Mediates the Regulated Endocytosis of the Aquaporin-2 Water Channel
- Stimulation of AQP2 Membrane Insertion in Renal Epithelial Cells In Vitro and In Vivo by the cGMP Phosphodiesterase Inhibitor Sildenafil Citrate (Viagra)
- Switch from an Aquaporin to a Glycerol Channel by Two Amino Acids Substitution
- The Effect of Eight V2 Vasopressin Receptor Mutations on Stimulation of Adenylyl Cyclase and Binding to Vasopressin
- The Ins and Outs of Aquaporin-2 Trafficking
- The Proteasome is Involved in the Degradation of Different Aquaporin-2 Mutants Causing Nephrogenic Diabetes Insipidus
- Tonicity-Responsive Enhancer Binding Protein is an Essential Regulator of Aquaporin-2 Expression in Renal Collecting Duct Principal Cells
- Two Novel Aquaporin-2 Mutations Responsible for Congenital Nephrogenic Diabetes Insipidus in Chinese Families
- Two Novel Mutations in the Vasopressin V2 Receptor Gene in Unrelated Japanese Kindreds with Nephrogenic Diabetes Insipidus
- Urinary Content of Aquaporin 1 and 2 in Nephrogenic Diabetes Insipidus
- V2 Vasopressin Receptor Dysfunction in Nephrogenic Diabetes Insipidus Caused By Different Molecular Mechanisms
- Water Channels Encoded by Mutant Aquaporin-2 Genes in Nephrogenic Diabetes Insipidus are Impaired in Their Cellular Routing
- Water Channels in Cell Membranes
- cDNA Cloning of a Functional Water Channel From Toad Urinary Bladder Epithelium
- cDNA and Genomic Cloning of Mouse Aquaporin-2: Functional Analysis of an Orthologous Mutant Causing Nephrogenic Diabetes Insipidus
Used in 9 Proceeding abstracts
Used in 9 Proceeding abstracts
- Aquaporin 2-containing Apical Membrane Endosomes (AQP-2 Endosomes) Possess a Multiprotein Signaling Complex
- Clinical presentation of the polyuric and hyperprostaglandinuric salt losing tubulopathies (HPS/aBS) and the therapeutic option with COX inhibitors
- Dysregulation of genes in rats with lithium-induced NDI
- Follow up of NDI patients and presentation of a case report
- Nephrogenic Diabetes Insipidus in mice lacking aquaporin-3 water channels
- New insights in water channel physiology revealed by transgenic mouse models
- The Medical Geneticist's Perspective on NDI Research
- Thirteen Large Deletions/Rearrangements of the AVPR2 Gene Causing X-linked Nephrogenic Diabetes Insipidus
- V2 vasopressin receptor dysfunction in patients with nephrogenic diabetes insipidus is caused by different molecular mechanisms
Used in 33 Proceeding translations
Used in 33 Proceeding translations
- A defect in AQP2 phosphorylation at Ser256 in the Golgi apparatus might explain the molecular basis of the dominant form of NDI caused by the mutation E258K-AQP2
- An impaired routing of wild type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
- Analysis of naturally occurring and in vitro mutations of the V2 receptor gene interfering with proper splicing
- Aquaporin-2 Expression in Primary Cultures of Rat Inner Medullary Collecting Duct Cells - A New In-Vitro Model System Facilitating the Study of the Vasopressin-Regulated Antidiuretic Machinery at the Cellular Level
- Clinical Data and Cell Biological Aspects of Mutations in Nephrogenic Diabetes Insipidus
- Clinical Phenotype and Molecular Characterization of A Mutant V2 Receptor Associated with Partial Congenital Nephrogenic Diabetes Insipidus
- Comparative analysis of human and murine vasopressin V2 receptor genes and their encoded proteins reveal striking differences in their genomic structure and functional properties
- Consequences of tetramerization and expression levels of Aquaporin-2 in phenotype-genotype correlation studies in autosomal NDI
- Decrease in urine volume and increase in urine osmolality after SR49059 administration in five adult male patients with X-linked nephrogenic diabetes insipidus
- Differences between ER-retained vasopressin V2 receptor mutants in antagonist-mediated restoration of cell surface expression
- Follow up of NDI patients and presentation of a case report
- Functional rescue of truncated V2-Vasopressin-receptors by aminoglycoside-induced misreading of nonsense-mutations
- Functional studies of twelve mutant V2 vasopressin receptors related to nephrogenic diabetes insipidus: molecular basis of a mild clinical phenotype.
- High proportion of ROMK processing defects underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome
- Hormone-regulated intrenalization of the vasopressin V2 receptor in a polarized renal collecting duct cell system
- Impaired routing of AQP2 to late endosomes/lysosomes following heterotetramerization with AQP2-E258K is likely to explain dominant nephrogenic diabetes insipidus
- Lithium-induced Nephrogenic Diabetes Insipidus: A Cell Culture Model
- Modulation of vasopressin-dependent AQP2 expression in cultured mpkCCDc14 collecting duct principal cells by aldosterone, insulin, and hypertonicity
- Mono-ubiquitination and missorting to lysosomes of the Aquaporin-2 water channel mutant AQP2-E258K explains dominant Nephrogenic Diabetes Insipidus
- Naturally occurring and in vitro mutations defining the role of the NPXXY motif in the vasopressin V2 receptor
- Osmolality and solute composition regulate aquaporin-2 expression in primary cultured renal principal cells
- Phenotype of aquaporin knockout mice, and AQP2 misprocessing in NDI
- Production and purification of Aquaporin-2 and Vasopressin 2 Receptor: towards elucidation of the structure
- Protein Kinase C involvement in aquaporin-2 endocytosis in cell culture
- Proteomic Studies of Vasopressin Action in the Collecting Duct
- Routing and function of mutant AQP2 water channels in nephrogenic diabetes insipidus
- Supplementation of Receptor Fragments: An approach to Functionally Rescue Mutant V2 Vasopressin Receptors
- The C-terminus of aquaporin-2 is necessary, but not sufficient, for routing of AQP2 to the apical membrane
- The Medical Geneticist's Perspective on NDI Research
- The stoichiometry of phosphorylated and non-phosphorylated monomers in an aquaporin-2 tetramer determines its subcellular localization
- Toward a mouse model of human non-X-linked NDI
- V2 Vasopressin Receptors in NDI: Where did they go?
- Vasopressin-induced / cyclic AMP-mediated aquaporin 2 translocation is a Ca2+-independent, slow exocytotic process



