mechanism
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- mechanism
Used in 57 Article abstracts
Used in 57 Article abstracts
- A Novel Mechanism in Recessive Nephrogenic Diabetes Insipidus: Wild-Type Aquaporin-2 Rescues the Apical Membrane Expression of Intracellularly Retained AQP2-P262L
- Agonist and Antagonist-Dependent Internalization of the Human Vasopressin V2 Receptor
- Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus
- Antidiuretic Action of Oxytocin is Associated with Increased Urinary Excretion of Aquaporin-2
- Antidiuretic Effect of Hydrochlorothiazide in Lithium-Induced Nephrogenic Diabetes Insipidus Is Associated with Upregulation of Aquaporin-2, Na-Cl Co-transporter, and Epithelial Sodium Channel
- Apical Extracellular Calcium/Polyvalent Cation-sensing Receptor Regulates Vasopressin-elicited Water Permeability in Rat Kidney Inner Medullary Collecting Duct
- Apparent Loss-of-Function Mutant GPCRs Revealed as Constitutively Desensitized Receptors
- Aquaporin-2 Water Channel Mutations Causing Nephrogenic Diabetes Insipidus
- Bradykinin Signaling Counteracts cAMP-elicited aquaporin 2 translocation in renal cells
- Chlorpropamide Upregulates Antidiuretic Hormone Receptors and Unmasks Constitutive Receptor Signaling
- Concentration of Solutes in the Renal Inner Medulla: Interstitial Hyaluronan as a Mechano-Osmotic Transducer
- Cross Talk Between Stimulatory and Inhibitory Guanosine 5'-Triphosphate Binding Proteins: Role in Activation and Desensitization of the Adenylate Cyclase Response to Vasopressin
- Cytoplasmic Dilution Induces Antidiuretic Hormone Water Channel Retrieval in Toad Urinary Bladder
- Detection of Skewed X-Inactivation in Two Female Carriers of Vasopressin Type 2 Receptor Gene Mutation
- Development of Lithium-Induced Nephrogenic Diabetes Insipidus is Dissociated from Adenylyl Cyclase Activity
- Disease-Causing V2 Vasopressin Receptors are Retained in Different Compartments of the Early Secretory Pathway
- Effects of Arginine Vasopressin and 1-Desamino-8-D Arginine Vasopressin on Forearm Vasculature of Healthy Subjects and Patients with a V2 Receptor Defect
- Endosomes from Kidney Collecting Tubule Cells Contain the Vasopressin-sensitive Water Channel
- Epinephrine and dDAVP Administration in Patients with Congenital Nephrogenic Diabetes Insipidus. Evidence for a pre-cyclic AMP V2 Receptor Defective Mechanism
- Expression Studies of Two Vasopressin V2 Receptor Gene Mutations, R202C and 804insG, in Nephrogenic Diabetes Insipidus
- Genetic Restoration of Aldose Reductase to the Collecting Tubules Restores Maturation of the Urine Concentrating Mechanism
- Heterogeneous AVPR2 Gene Mutations in Congenital Nephrogenic Diabetes Insipidus
- Heteroligomerization of an Aquaporin-2 Mutant with Wild-Type Aquaporin-2 and Their Misrouting to Late Endosomes/Lysosomes Explains Dominant Nephrogenic Diabetes Insipidus
- Hypertonicity Regulates the Aquaporin-2 Promoter Independently of Arginine Vasopressin
- Identification of a Multiprotein "Motor" Complex Binding to Water Channel Aquaporin-2
- Lithium-induced Nephrogenic Diabetes Insipidus
- Long-Term Regulation of Urinary Concentrating Capacity
- Maternal Lithium Therapy and Polyhydramnios
- Mechanism of Antidiuresis Caused by Bendroflumethiazide in Conscious Rats with Diabetes Insipidus
- Meniere's Disease in Congenital Nephrogenic Diabetes Insipidus: Report of Two Twins
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking
- Molecular Physiology of Urinary Concentrating Mechanism: Regulation of Aquaporin Water Channels by Vasopressin
- Molecular and Cellular Biology of Vasopressin and Oxytocin Receptors and Action in the Kidney
- Mutations in the Vasopressin V2 Receptor Gene in Two Families with Nephrogenic Diabetes Insipidus
- Nephrogenic diabetes insipidus.
- Osmoregulation and Baroregulation of Plasma Vasopressin in Essential Hypertension
- Pathogenesis and Treatment of Autosomal-Dominant Nephrogenic Diabetes Insipidus Caused by an Aquaporin 2 Mutation
- Pathophysiology of the Aquaporin Water Channels
- Pharmacological Chaperones in Nephrogenic Diabetes Insipidus: Possibilities for Clinical Application
- Phenotypes Developed in Secretin Receptor-Null Mice Indicated a Role for Secretin in Regulating Renal Water Reabsorption
- Reconstitution of Mutant V2 Vasopressin Receptors by Adenovirus-mediated Gene Transfer
- Regulation of Aquaporin-2 Trafficking by Vasopressin in the Renal Collecting Duct
- Rescue of Vasopressin V2 Receptor Mutants by Chemical Chaperones: Specificity and Mechanism
- Role of the Ca2+-Sensing Receptor in Divalent Mineral Ion Homeostasis
- Short-Chain Ubiquitination Mediates the Regulated Endocytosis of the Aquaporin-2 Water Channel
- The Perinatal Expression of Aquaporin-2 and Aquaporin-3 in Developing Kidney
- The Property of a Novel V2 Receptor Mutant in a Patient with Nephrogenic Diabetes Insipidus
- The role of actin remodeling in the trafficking of intracellular vesicles, transporters, and channels: focusing on aquaporin-2
- Transient Nephrogenic Diabetes Insipidus Accompanied by Possible Psychogenic Polydipsia
- Two Vasopressin Type 2 Receptor Gene Mutations R143P and Delta V278 in Patients with Nephrogenic Diabetes Insipidus Impair Ligand Binding of the Receptor
- Upregulation of Aquaporin 2 Water Channel Expression in Pregnant Rats
- V2R Structure and Diabetes Insipidus
- Vasopressin Increases Urinary Albumin Excretion in Rats and Humans: Involvement of V2 Receptors and the Renin-Angiotensin System
- Vasopressin Increases Water Permeability of Kidney Collecting Duct by Inducing Translocation of Aquaporin-CD Water Channels to Plasma Membrane
- Vasopressin-Independent Renal Urinary Concentration: Increased rBSC1 and Enhanced Countercurrent Multiplication
- Water Channel Aquaporin-2 Directly Binds to Actin
Used in 9 Article bodies
Used in 9 Article bodies
- Evidence that the Antidiuretic Substance in the Plasma of Children with Nephrogenic Diabetes Insipidus is Antidiuretic Hormone
- Hyperosmolar Coma and Lithium-induced Diabetes Insipidus
- Lithium-Induced Nephrogenic Diabetes Insipidus Treated with Indomethacin
- Nephrogenic Diabetes Insipidus Secondary to Lithium Therapy in the Postoperative Patient: A Case Report
- Nephrogenic Diabetes Insipidus: Transmitted by Females and Appearing During Infancy in Males
- Persistent Nephrogenic Diabetes Insipidus Following Lithium Therapy
- Proposed Cause of Marked Vasopressin Resistance in a Female with an X-Linked Recessive V2 Receptor Abnormality
- Role of Aquaporin-2 Water Channels in Urinary Concentration and Dilution Defects
- Role of Vasopressin in Abnormal Water Excretion in Cirrhotic Patients
Used in 42 Article translations
Used in 42 Article translations
- Aldose Reductase-Deficient Mice Develop Nephrogenic Diabetes Insipidus
- An Impaired Routing of Wild-type Aquaporin-2 after Tetramerization with an Aquaporin-2 Mutant Explains Dominant Nephrogenic Diabetes Insipidus
- Calcineurin-NFATc Signaling Pathway Regulates AQP2 Expression in Response to Calcium Signals and Osmotic Stress
- Cellular Mechanism of Lithium-Induced Nephrogenic Diabetes Insipidus in Rats
- Characterization of Vasopressin V2 Receptor Mutants in Nephrogenic Diabetes Insipidus in a Polarized Cell Model
- Cross Talk Between Stimulatory and Inhibitory Guanosine 5'-Triphosphate Binding Proteins: Role in Activation and Desensitization of the Adenylate Cyclase Response to Vasopressin
- Cytoplasmic Dilution Induces Antidiuretic Hormone Water Channel Retrieval in Toad Urinary Bladder
- Defective Aquaporin-2 Trafficking in Nephrogenic Diabetes Insipidus and Correction by Chemical Chaperones
- Development of Lithium-Induced Nephrogenic Diabetes Insipidus is Dissociated from Adenylyl Cyclase Activity
- Effects of Arginine Vasopressin and 1-Desamino-8-D Arginine Vasopressin on Forearm Vasculature of Healthy Subjects and Patients with a V2 Receptor Defect
- From Vasopressin Receptor to Water Channel: Intracellular Traffic, Constraint and By-pass
- GS-Activating Receptors: Modes of Transmembrane Signalling and Genetic Defects
- High Serum Immunoreactive Trypsin Not Caused by Cystic Fibrosis (letter)
- Hypokalemic Nephropathy and Nephrogenic Diabetes Insipidus Due to Excessive Consumption of a Soft Drink
- Indomethacin in the Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus
- Long-Term Regulation of Urinary Concentrating Capacity
- Mechanism of Antidiuresis Caused by Bendroflumethiazide in Conscious Rats with Diabetes Insipidus
- Mechanisms and Regulation of Water Permeability in Renal Epithelia
- Molecular Mechanisms for the Regulation of Water Transport in Amphibian Epithelia by Antidiuretic Hormone
- Mutations in the Founder of the MIP Gene Family Underlie Cataract Development in the Mouse
- Mutations in the Vasopressin V2 Receptor Gene in Two Families with Nephrogenic Diabetes Insipidus
- Nephrogenic Diabetes Insipidus Associated with Foscarnet - A Case Report [letter]
- Nephrogenic Diabetes Insipidus Caused By Mutation of Tyr205: A Key Residue of V2 Vasopressin Receptor Function
- Nephrogenic Diabetes Insipidus Secondary to Lithium Therapy in the Postoperative Patient: A Case Report
- Novel Mutations in the V2 Vasopressin Receptor Gene of Patients with X-Linked Nephrogenic Diabetes Insipidus
- Pathophysiology of the Aquaporin Water Channels
- Pharmacochaperones Post-Translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-Type and Mutant Vasopressin V2 Receptors
- Phenotypes Developed in Secretin Receptor-Null Mice Indicated a Role for Secretin in Regulating Renal Water Reabsorption
- Recent Advances in Water Transport
- Reconstitution of Mutant V2 Vasopressin Receptors by Adenovirus-mediated Gene Transfer
- Regulation of Collecting Duct Water Channel Expression by Vasopressin in Brattleboro Rat
- Rescue of Vasopressin V2 Receptor Mutants by Chemical Chaperones: Specificity and Mechanism
- Rolipram, a Phosphodiesterase Inhibitor, in the Treatment of Two Male Patients with Congenital Nephrogenic Diabetes Insipidus
- Therapeutic Potential of Vasopressin Receptor Antagonists
- Tonicity-Responsive Enhancer Binding Protein is an Essential Regulator of Aquaporin-2 Expression in Renal Collecting Duct Principal Cells
- Two Vasopressin Type 2 Receptor Gene Mutations R143P and Delta V278 in Patients with Nephrogenic Diabetes Insipidus Impair Ligand Binding of the Receptor
- Upregulation of Urea Transporter UT-A2 and Water Channels AQP2 and AQP3 in Mice Lacking Urea Transporter UT-B
- Urinary Concentrating Mechanism: The Role of the Inner Medulla
- Vasopressin-Independent Renal Urinary Concentration: Increased rBSC1 and Enhanced Countercurrent Multiplication
- Vasopressin-Sensitive Adenylate Cyclase: Subunit Interactions Assessed by Target Analysis and Computer Modelling
- Water Channels Encoded by Mutant Aquaporin-2 Genes in Nephrogenic Diabetes Insipidus are Impaired in Their Cellular Routing
- cDNA and Genomic Cloning of Mouse Aquaporin-2: Functional Analysis of an Orthologous Mutant Causing Nephrogenic Diabetes Insipidus
Used in 21 Proceeding abstracts
Used in 21 Proceeding abstracts
- Renal medullary gene expression in aquaporin-1 null mice
- Action Mechanism of Pharmacological Chaperones Acting on the V2 Vasopressin Receptor in the Treatment of Nephrogenic Diabetes Insipidus
- Antidiuretic Effect of Hydrochlorothiazide in Lithium-Induced Nephrogenic Diabetes Insipidus Is Associated with Upregulation of Aquaporin-2, Na-Cl Cotransporter and Epithelial Sodium Channel
- Calcineurin A-alpha knockout is a new model of nephrogenic diabetes insipidus
- Clinical Phenotype and Molecular Characterization of A Mutant V2 Receptor Associated with Partial Congenital Nephrogenic Diabetes Insipidus
- Decrease in urine volume and increase in urine osmolality after SR49059 administration in five adult male patients with X-linked nephrogenic diabetes insipidus
- Differences between ER-retained vasopressin V2 receptor mutants in antagonist-mediated restoration of cell surface expression
- High proportion of ROMK processing defects underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome
- Lithium-induced Nephrogenic Diabetes Insipidus: A Cell Culture Model
- Long- and Short-Term Regulation of AQP2 Expression and Function
- Mono-ubiquitination and missorting to lysosomes of the Aquaporin-2 water channel mutant AQP2-E258K explains dominant Nephrogenic Diabetes Insipidus
- Phenotype of aquaporin knockout mice, and AQP2 misprocessing in NDI
- Production and purification of Aquaporin-2 and Vasopressin 2 Receptor: towards elucidation of the structure
- Purinergic Control of Medullary Collecting Duct Function: A Novel Vasopressin-independent Regulatory Mechanism
- Regulation of Aquaporin-2 trafficking by Vasopressin in Renal Collecting Duct: Roles of Ryanodine-Sensitive Ca2+ Stores and Calmodulin
- Structure of V2 vasopressin receptor oligomers: evidence for contact dimer formation
- The last fifty years; a retrospective on NDI
- V2 vasopressin receptor mutants responsible for nephrogenic diabetes insipidus associate with the molecular chaperones calnexin and Hsp70
- Variations in clinical phenotype associated with different mutations of the V2 receptor gene in X-linked recessive congenital nephrogenic DI (xCNDI)
- Vasopressin-induced / cyclic AMP-mediated aquaporin 2 translocation is a Ca2+-independent, slow exocytotic process
- Wild-type aquaporin-2 rescues a novel aquaporin-2 mutant in recessive Nephrogenic Diabetes Insipidus to the apical plasma membrane
Used in 28 Term definitions
Used in 28 Term definitions
- acute febrile polyneuritis
- acute idiopathic polyneuritis
- anthracycline
- antiport
- apoptosis
- common pathway of coagulation
- countercurrent
- countercurrent multiplication
- extrinsic pathway of coagulation
- factor
- gate
- gene repression
- genetic disease
- helices
- helix
- heterogeneity
- hypothalamus
- isozyme
- malate-aspartate shuttle
- mechanical
- mechanically
- pain
- para-aminohippuric acid
- paralysis
- shuttle
- shuttling
- sodium pump
- vitalism



