protein kinase C
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- protein kinase C
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Any of a family of protein kinase isozymes, occurring in numerous tissues, that catalyze the phosphorylation of specific serine or threonine residues of a variety of intracellular proteins, altering their activities. The enzymes are activated via receptor binding by the hormones, growth factors, and other agents that cause increases in intracellular calcium and cleavage of phosphoinositides; some isozymes require calcium and phospholipid for activity, which is enhanced by diacylglycerol. The enzyme is involved in several types of cellular signal transduction and has been shown to play a role in platelet activation and in the inhibition of some peptide hormone receptors and to be a binding site for phorbol esters and other tumor promoters, as well as having numerous other roles and substrates, only some of which are known.
Used in 6 Article abstracts
Used in 6 Article abstracts