receptor
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- receptor
-
1. A molecular structure within a cell or on the surface characterized by (1) selective binding of a specific substance and (2) a specific physiologic effect that accompanies the binding, e.g., membrane receptors for peptide hormones, neurotransmitters, antigens, complement fragments, and immunoglobulins and nuclear receptors for steroid hormones.
2. A sensory nerve terminal that responds to stimuli of various kinds; classified in various ways including by the type of stimulus and by the location in the body.
V2 receptor - The structure to which the antidiuretic hormone, arginine vasopressin binds.
Used in 130 Article abstracts
Used in 130 Article abstracts
- A Dileucine Sequence and an Upstream Glutamate Residue in the Intracellular Carboxyl Terminus of the Vasopressin V2 Receptor are Essential for Cell Surface Transport in COS.M6 Cells
- A Fully Active Nonglycosylated V2 Vasopressin Receptor
- A Low-Affinity Vasopressin V2-Receptor Gene in a Kindred with X-Linked Nephrogenic Diabetes Insipidus
- A Novel Polymorphism in the Coding Region of the Vasopressin Type 2 Receptor Gene
- A Null Mutation in the Vasopressin V2 Receptor Gene (AVPR2) Associated with Nephrogenic Diabetes Insipidus in the Hopewell Kindred
- A Role for K268 in V2R Folding
- A Serine Cluster Prevents Recycling of the V2 Vasopressin Receptor
- AVPR2 Variants and V2 Vasopressin Receptor Function in Nephrogenic Diabetes Insipidus
- Acute Effects of Vasopressin V2-Receptor Antagonist on Kidney AQP2 Expression and Subcellular Distribution
- Agonist and Antagonist-Dependent Internalization of the Human Vasopressin V2 Receptor
- Aminoglycoside-Mediated Rescue of a Disease-Causing Nonsense Mutation in the V2 Vasopressin Receptor Gene In Vitro and In Vivo
- An Extracellular Congenital Nephrogenic Diabetes Insipidus Mutation of the Vasopressin Receptor Reduces Cell Surface Expression, Affinity for Ligand, and Coupling to the Gs/adenylyl Cyclase System
- An X-linked NDI Mutation Reveals a Requirement for Cell Surface V2R Expression
- Angiotensin II AT1 Receptor Blockade Decreases Vasopressin-Induced Water Reabsorption and AQP2 Levels in NaCl-Restricted Rats
- Angiotensin II Upregulates the Expression of Vasopressin V2 mRNA in the Inner Medullary Collecting Duct of the Rat
- Apical Extracellular Calcium/Polyvalent Cation-sensing Receptor Regulates Vasopressin-elicited Water Permeability in Rat Kidney Inner Medullary Collecting Duct
- Apparent Loss-of-Function Mutant GPCRs Revealed as Constitutively Desensitized Receptors
- Appropriate Polarization Following Pharmacological Rescue of V2 Vasopressin Receptors Encoded by X-Linked Nephrogenic Diabetes Insipidus Alleles Involves a Conformation of the Receptor That Also Attains Mature Glycosylation
- Association of Calnexin With Wild Type and Mutant AVPR2 that Cause Nephrogenic Diabetes Insipidus
- Binding-, Intracellular Transport-, and Biosynthesis-Defective Mutants of Vasopressin Type 2 Receptor in Patients with X-Linked Nephrogenic Diabetes Insipidus
- Biochemical Basis of Partial Nephrogenic Diabetes Insipidus Phenotypes
- Bradykinin Signaling Counteracts cAMP-elicited aquaporin 2 translocation in renal cells
- Chlorpropamide Upregulates Antidiuretic Hormone Receptors and Unmasks Constitutive Receptor Signaling
- Cloning and Characterization of a Vasopressin V2 Receptor and Possible Link to Nephrogenic Diabetes Insipidus
- Constitutive Arrestin-Mediated Desensitization of a Human Vasopressin Receptor Mutant Associated with Nephrogenic Diabetes Insipidus
- Cross Talk Between Stimulatory and Inhibitory Guanosine 5'-Triphosphate Binding Proteins: Role in Activation and Desensitization of the Adenylate Cyclase Response to Vasopressin
- Defects of G Protein-Coupled Signal Transduction in Human Disease
- Derivatives of Somatic Cell Hybrids Which Carry the Human Gene Locus for Nephrogenic Diabetes Insipidus (NDI) Express Functional Vasopressin Renal V2-type Receptors
- Desensitization of the Human V2 Vasopressin Receptor. Homologous Effects in the Absence of Heterologous Desensitization
- Development and Characterization of a Mouse Cell Line Expressing the Human V2 Vasopressin Receptor Gene
- Different Single Receptor Domains Determine the Distinct G Protein Coupling Profiles of Members of the Vasopressin Receptor Family
- Diversity of Nephrogenic Diabetes Insipidus Mutations and Importance of Early Recognition and Treatment
- Dual Actions of Vasopressin and Oxytocin in Regulation of Water Permeability in Terminal Collecting Duct
- Endocytosis in Renal Proximal Tubules. Experimental Electron Microscopical Studies of Protein Absorption and Membrane Traffic in Isolated, In Vitro Perfused Proximal Tubules
- Evidence for Dual Signaling Pathways for V2 Vasopressin Receptor in Rat Inner Medullary Collecting Duct
- Evidence for Intact V1-vasopressin Receptors in Congenital Nephrogenic Diabetes Insipidus
- Evidence for a Role of Protein Kinase C-a in Urine Concentration
- Expression Studies of Two Vasopressin V2 Receptor Gene Mutations, R202C and 804insG, in Nephrogenic Diabetes Insipidus
- Expression of Vasopressin V1a and V2 Receptor Messenger Ribonucleic Acid in the Liver and Kidney of Embryonic, Developing, and Adult Rats
- Extracellular Nucleotide Receptor Inhibits AVP-Stimulated Water Permeability in Inner Medullary Collecting Duct
- Fibrinolytic Responses to 1-desamino-8-D-arginine-vasopressin in Patients with Congenital Nephrogenic Diabetes Insipidus
- First Intracellular Loop of the Human Cholecystokinin-A Receptor is Essential for Cyclic AMP Signaling in Transfected HEK-293 Cells
- Folding and Cell Surface Expression of the Vasopressin V2 Receptor: Requirement of the Intracellular C-terminus
- Functional Characterization of Five V2 Vasopressin Receptor Gene Mutations
- Functional Characterization of the Molecular Defects Causing Nephrogenic Diabetes Insipidus in Eight Families
- Functional Rescue of Mutant V2 Vasopressin Receptors Causing Nephrogenic Diabetes Insipidus by a Co-Expressed Receptor Polypeptide
- Functional Rescue of Vasopressin V2 Receptor Mutants in MDCK Cells by Pharmacochaperones: Relevance to Therapy of Nephrogenic Diabetes Insipidus
- Functional Rescue of the Constitutively Internalized V2 Vasopressin Receptor Mutant R137H by the Pharmacological Chaperone Action of SR49059
- Functional Rescue of the Nephrogenic Diabetes Insipidus-Causing Vasopressin V2 Receptor Mutants G185C and R202C by a Second Site Suppressor Mutation
- Functional Role of the NPxxY Motif in Internalization of the Type 2 Vasopressin Receptor in LLC-PK1 Cells
- Functional Studies of Twelve Mutant V2 Vasopressin Receptors Related to Nephrogenic Diabetes Insipidus: Molecular Basis of a Mild Clinical Phenotype
- G-Protein-Coupled Receptors: Molecular Mechanisms Involved in Receptor Activation and Selectivity of G-Protein Recognition
- GIP, a G-Protein-Coupled Receptor Interacting Protein
- Genetics of Vasopressin Receptors
- Heterogeneous AVPR2 Gene Mutations in Congenital Nephrogenic Diabetes Insipidus
- Hormone and Autacoid Regulation of cAMP Production in Rat IMCD Subsegments
- Human Platelet Fraction Arginine-Vasopressin. Potential Physiological Role
- Hyperuricemia as a Clue for Central Diabetes Insipidus (Lack of V1 Effect) in the Differential Diagnosis of Polydipsia
- Identification of Agonist Binding Sites of Vasopressin and Oxytocin Receptors
- Inhibition of Endocytosis Causes Phosphorylation (S256)-Independent Plasma Membrane Accumulation of AQP-2
- Intrafamilial Phenotype Variability in Nephrogenic Diabetes Insipidus
- Long Term Regulation of Aquaporin-2 Expression in Vasopressin-responsive Renal Collecting Duct Principal Cells
- Maturation of Receptor Proteins in Eukaryotic Expression Systems
- Membrane Targeting and Determination of Transmembrane Topology of the Human Vasopressin V2 Receptor
- Misfolded Vasopressin V2 Receptors Caused by Extracellular Point Mutations Entail Congenital Nephrogenic Diabetes Insipidus.
- Molecular Aspects of Vasopressin Receptor Function
- Molecular Basis of V2 Vasopressin Receptor/Gs Coupling Selectivity
- Molecular Cloning of the Receptor for Human Antidiuretic Hormone
- Molecular Neurobiology and Pharmacology of the Vasopressin/Oxytocin Receptor Family
- Molecular and Cellular Defects in Nephrogenic Diabetes Insipidus
- Molecular and Cellular Defects in Nephrogenic Diabetes Insipidus (Knoers, Deen)
- Mutations and Diseases of G Protein Coupled Receptors
- Mutations in the V2 Vasopressin Receptor Gene are Associated with X-linked Nephrogenic Diabetes Insipidus
- Mutations in the Vasopressin Type 2 Receptor Gene (AVPR2) Associated with Nephrogenic Diabetes Insipidus
- Nephrogenic Diabetes Insipidus (Bichet - November 1998)
- Nephrogenic Diabetes Insipidus Caused By Mutation of Tyr205: A Key Residue of V2 Vasopressin Receptor Function
- Nephrogenic Diabetes Insipidus. A V2 Vasopressin Receptor Unable to Stimulate Adenylyl Cyclase
- Nephrogenic Diabetes Insipidus: An X Chromosome-Linked Dominant Inheritance Pattern with a Vasopressin Type 2 Receptor Gene that is Structurally Normal
- Nephrogenic Diabetes Insipidus: Clinical Symptoms, Pathogenesis, Genetics and Treatment
- Nephrogenic Diabetes Insipidus: Functional Analysis of New AVPR2 Mutations Identified in Italian Families
- Nephrogenic Diabetes Insipidus: Identification of the Genetic Defect
- Novel Down-Regulatory Mechanism of the Surface Expression of Vasopressin V2 Receptor by an Alternative Splice Receptor Variant
- Novel Vasopressin Type 2 (AVPR2) Gene Mutations in Brazilian Nephrogenic Diabetes Insipidus Patients
- Oxytocin as an Antidiuretic Hormone. II. Role of V2 Vasopressin Receptor
- Palmitoylation of the V2 Vasopressin Receptor
- Pharmacochaperones Post-Translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-Type and Mutant Vasopressin V2 Receptors
- Pharmacologic Chaperones as a Potential Treatment for X-linked Nephrogenic Diabetes Insipidus
- Pharmacological Chaperones in Nephrogenic Diabetes Insipidus: Possibilities for Clinical Application
- Phenotypes Developed in Secretin Receptor-Null Mice Indicated a Role for Secretin in Regulating Renal Water Reabsorption
- Phosphorylation of the V2 Vasopressin Receptor
- Plasma Membrane Localization and Functional Rescue of Truncated Forms of a G Protein-coupled Receptor
- Platelet Vasopressin Receptors in Patients With Congenital Nephrogenic Diabetes Insipidus
- Properties of the Human Arginine Vasopressin V2 Receptor after Site-Directed Mutagenesis of its Putative Palmitoylation Site
- Proposed Cause of Marked Vasopressin Resistance in a Female with an X-Linked Recessive V2 Receptor Abnormality
- Proteomic Analysis of Long-Term Vasopressin Action in Inner Medullary Collecting Duct of Brattleboro Rat
- Reconstitution of Mutant V2 Vasopressin Receptors by Adenovirus-mediated Gene Transfer
- Regulation of Aquaporin-2 Trafficking by Vasopressin in the Renal Collecting Duct
- Regulation of V2 Vasopressin Receptor Degradation by Agonist Promoted Ubiquitination
- Rescue of Vasopressin V2 Receptor Mutants by Chemical Chaperones: Specificity and Mechanism
- Role of the Ca2+-Sensing Receptor in Divalent Mineral Ion Homeostasis
- Routing of the aquaporin-2 water channel in health and disease.
- Signal Transduction by G Proteins: 1994 Edition
- Sorting Functions of the Individual Cytoplasmic Domains of the G Protein-Coupled Vasopressin V2 Receptor in Madin Darby Canine Kidney Epithelial Cells
- Stimulation of AQP2 Membrane Insertion in Renal Epithelial Cells In Vitro and In Vivo by the cGMP Phosphodiesterase Inhibitor Sildenafil Citrate (Viagra)
- Structural Implication for Receptor Oligomerization from Functional Reconstitution Studies of Mutant V2 Vasopressin Receptors
- Structure and Chromosomal Localization of the Human Antidiuretic Hormone Receptor Gene
- The Effect of Eight V2 Vasopressin Receptor Mutations on Stimulation of Adenylyl Cyclase and Binding to Vasopressin
- The Hydrophobic Amino Acid Residues in the Membrane-Proximal C Tail of the G Protein-Coupled Vasopressin V2 Receptor are Necessary for Transport-Competent Receptor Folding
- The Ins and Outs of Aquaporin-2 Trafficking
- The Interaction of Blood Osmolality and Blood Volume in Regulating Plasma Vasopressin in Man
- The Property of a Novel V2 Receptor Mutant in a Patient with Nephrogenic Diabetes Insipidus
- The V2 vasopressin receptor mutations and fluid homeostasis.
- Therapeutic Potential of Vasopressin Receptor Antagonists
- Three Novel AVPR2 Mutations in Three Japanese Families with X-Linked Nephrogenic Diabetes Insipidus
- Trafficking Patterns of Beta -Arrestin and G-Protein-Coupled Receptors Determined by the Kinetics of Beta -Arrestin Deubiquitination
- Truncated V2 Vasopressin Receptors as Negative Regulators of Wild-Type V2 Receptor Function
- Two Novel Mutations in the Aquaporin-2 and the Vasopressin V2 Receptor Genes in Patients with Congenital Nephrogenic Diabetes Insipidus
- Two Vasopressin Type 2 Receptor Gene Mutations R143P and Delta V278 in Patients with Nephrogenic Diabetes Insipidus Impair Ligand Binding of the Receptor
- Vasopressin Increases Urinary Albumin Excretion in Rats and Humans: Involvement of V2 Receptors and the Renin-Angiotensin System
- Vasopressin Receptor Mutations Causing Nephrogenic Diabetes Insipidus
- Vasopressin Receptor Mutations and Nephrogenic Diabetes Insipidus
- Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus
- Vasopressin V2 Receptor Mutants that Cause X-linked Nephrogenic Diabetes Insipidus: Analysis of Expression, Processing, and Function
- Vasopressin and Oxytocin Receptors
- Vasopressin and Oxytocin Receptors Coupled to Ca2+ Mobilization in Rat Inner Medullary Collecting Duct
- Vasopressin receptors.
- [Congenital Nephrogenic Diabetes Insipidus] (French)
- [Hereditary Nephrogenic Diabetes Insipidus] (French)
- [Nephrogenic Diabetes Insipidus] (Japanese)
- [Recent Advances in Vasopressin Receptors and Signal Transduction System] (Japanese)
Used in 6 Article bodies
Used in 6 Article bodies
- A Novel Polymorphism in the Coding Region of the Vasopressin Type 2 Receptor Gene
- Hereditary Vasopressin Resistance in Man and Mouse
- Inborn Errors of Signal Transduction: Mutations in G Proteins and G Protein-coupled Receptors as a Cause of Disease
- Molecular Analysis of X-Linked Nephrogenic Diabetes Insipidus
- Proposed Cause of Marked Vasopressin Resistance in a Female with an X-Linked Recessive V2 Receptor Abnormality
- Role of Aquaporin-2 Water Channels in Urinary Concentration and Dilution Defects
Used in 84 Article translations
Used in 84 Article translations
- A Fully Active Nonglycosylated V2 Vasopressin Receptor
- A Low-Affinity Vasopressin V2-Receptor Gene in a Kindred with X-Linked Nephrogenic Diabetes Insipidus
- A Novel Mechanism in Recessive Nephrogenic Diabetes Insipidus: Wild-Type Aquaporin-2 Rescues the Apical Membrane Expression of Intracellularly Retained AQP2-P262L
- A Serine Cluster Prevents Recycling of the V2 Vasopressin Receptor
- A Variant of Nephrogenic Diabetes Insipidus: V2 Receptor Abnormality Restricted to the Kidney
- ADH Resistance of LLC-pk1 Cells Caused by Overexpression of cAMP-Phosphodiesterase Type-IV
- Activation of the Vasopressin-sensitive Water Permeability Pathway in the Toad Bladder by N-ethyl Maleimide
- Aminoglycoside Pretreatment Partially Restores the Function of Truncated V2 Vasopressin Receptors Found in Patients with Nephrogenic Diabetes Insipidus
- An X-linked NDI Mutation Reveals a Requirement for Cell Surface V2R Expression
- Analysis of Vasopressin Receptor Type II (V2R) Gene in Three Japanese Pedigrees with Congenital Nephrogenic Diabetes Insipidus: Identification of a Family with Complete Deletion of the V2R Gene
- Angiotensin II AT1 Receptor Blockade Decreases Vasopressin-Induced Water Reabsorption and AQP2 Levels in NaCl-Restricted Rats
- Binding-, Intracellular Transport-, and Biosynthesis-Defective Mutants of Vasopressin Type 2 Receptor in Patients with X-Linked Nephrogenic Diabetes Insipidus
- Brief Report: A Mutation in the Vasopressin V2-Receptor Gene in a Kindred with X-Linked Nephrogenic Diabetes Insipidus
- Cellular Mechanism of Lithium-Induced Nephrogenic Diabetes Insipidus in Rats
- Cloning and Characterization of a Vasopressin V2 Receptor and Possible Link to Nephrogenic Diabetes Insipidus
- Cloning, Characterization, and Chromosomal Mapping of Human Aquaporin of Collecting Duct
- Cognitive and Psychosocial Functioning of Patients with Congenital Nephrogenic Diabetes Insipidus
- Cross Talk Between Stimulatory and Inhibitory Guanosine 5'-Triphosphate Binding Proteins: Role in Activation and Desensitization of the Adenylate Cyclase Response to Vasopressin
- Defects of G Protein-Coupled Signal Transduction in Human Disease
- Desensitization of the Human V2 Vasopressin Receptor. Homologous Effects in the Absence of Heterologous Desensitization
- Development and Characterization of a Mouse Cell Line Expressing the Human V2 Vasopressin Receptor Gene
- Different Single Receptor Domains Determine the Distinct G Protein Coupling Profiles of Members of the Vasopressin Receptor Family
- Discovery of Aquaporins: a Breakthrough in Research on Renal Water Transport
- Dual Actions of Vasopressin and Oxytocin in Regulation of Water Permeability in Terminal Collecting Duct
- Effects of Arginine Vasopressin and 1-Desamino-8-D Arginine Vasopressin on Forearm Vasculature of Healthy Subjects and Patients with a V2 Receptor Defect
- Expression Studies of Two Vasopressin V2 Receptor Gene Mutations, R202C and 804insG, in Nephrogenic Diabetes Insipidus
- Fate of Antidiuretic Hormone Water Channel Proteins after Retrieval from Apical Membrane
- Fibrinolytic Responses to 1-desamino-8-D-arginine-vasopressin in Patients with Congenital Nephrogenic Diabetes Insipidus
- Folding and Cell Surface Expression of the Vasopressin V2 Receptor: Requirement of the Intracellular C-terminus
- From Vasopressin Receptor to Water Channel: Intracellular Traffic, Constraint and By-pass
- Functional Characterization of Five V2 Vasopressin Receptor Gene Mutations
- Functional Rescue of Mutant V2 Vasopressin Receptors Causing Nephrogenic Diabetes Insipidus by a Co-Expressed Receptor Polypeptide
- Functional Rescue of Vasopressin V2 Receptor Mutants in MDCK Cells by Pharmacochaperones: Relevance to Therapy of Nephrogenic Diabetes Insipidus
- Functional Studies of Twelve Mutant V2 Vasopressin Receptors Related to Nephrogenic Diabetes Insipidus: Molecular Basis of a Mild Clinical Phenotype
- G-Protein-Coupled Receptors in Endocrine Disease
- G-Protein-Coupled Receptors: Molecular Mechanisms Involved in Receptor Activation and Selectivity of G-Protein Recognition
- GS-Activating Receptors: Modes of Transmembrane Signalling and Genetic Defects
- Hemodynamic and Coagulation Responses to 1-desamino[8-D-arginine] Vasopressin in Patients with Congenital Nephrogenic Diabetes Insipidus
- Hereditary Vasopressin Resistance in Man and Mouse
- Heterogeneous AVPR2 Gene Mutations in Congenital Nephrogenic Diabetes Insipidus
- In Vitro Micro-Autoradiography of Atrial Natriuretic Peptide in Biopsy Specimens from Patients with Renal Diseases
- Inborn Errors of Signal Transduction: Mutations in G Proteins and G Protein-coupled Receptors as a Cause of Disease
- Inhibition of Endocytosis Causes Phosphorylation (S256)-Independent Plasma Membrane Accumulation of AQP-2
- Maturation of Receptor Proteins in Eukaryotic Expression Systems
- Mechanism of Vasopressin Action in the Renal Collecting Duct
- Mechanisms and Regulation of Water Transport in the Kidney
- Membrane Targeting and Determination of Transmembrane Topology of the Human Vasopressin V2 Receptor
- Meniere's Disease in Congenital Nephrogenic Diabetes Insipidus: Report of Two Twins
- Molecular Biology of Diabetes Insipidus
- Molecular Cloning of the Receptor for Human Antidiuretic Hormone
- Molecular Insights into the Pathogenesis of Inherited Renal Tubular Disorders
- Molecular and Cellular Biology of Vasopressin and Oxytocin Receptors and Action in the Kidney
- Molecular and Cellular Defects in Nephrogenic Diabetes Insipidus
- Mutations and Diseases of G Protein Coupled Receptors
- Mutations in the V2 Vasopressin Receptor Gene are Associated with X-linked Nephrogenic Diabetes Insipidus
- Mutations in the Vasopressin V2 Receptor Gene in Families with Nephrogenic Diabetes Insipidus and Functional Expression of the Q-2 Mutant
- Nature and Recurrence of AVPR2 Mutations in X-Linked Nephrogenic Diabetes Insipidus
- Nephrogenic Diabetes Insipidus: Clinical Symptoms, Pathogenesis, Genetics and Treatment
- Normal Hemodynamic and Coagulation Responses to 1-Diamino-8-D-Arginine Vasopressin in a Case of Lithium-Induced Nephrogenic Diabetes Insipidus. Results of Treatment by a Prostaglandin Synthesis Inhibitor (Indomethacin).
- Novel Mutations in the V2 Vasopressin Receptor Gene of Patients with X-Linked Nephrogenic Diabetes Insipidus
- Pharmacochaperones Post-Translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-Type and Mutant Vasopressin V2 Receptors
- Pharmacologic Chaperones as a Potential Treatment for X-linked Nephrogenic Diabetes Insipidus
- Pharmacological Chaperones in Nephrogenic Diabetes Insipidus: Possibilities for Clinical Application
- Phenotypes Developed in Secretin Receptor-Null Mice Indicated a Role for Secretin in Regulating Renal Water Reabsorption
- Phosphorylation of the V2 Vasopressin Receptor
- Platelet Vasopressin Receptors in Patients With Congenital Nephrogenic Diabetes Insipidus
- Properties of the Human Arginine Vasopressin V2 Receptor after Site-Directed Mutagenesis of its Putative Palmitoylation Site
- Role of Aquaporins in Water Balance Disorders
- Role of Sodium Depletion in Acute Antidiuretic Effect of Bendroflumethiazide in Rats with Nephrogenic Diabetes Insipidus
- The Aquaporin Family of Molecular Water Channels
- The Aquaporin Family of Water Channels in Kidney: an Update on Physiology and Pathophysiology of Aquaporin-2
- The Cellular Action of Antidiuretic Hormone
- The Hydrophobic Amino Acid Residues in the Membrane-Proximal C Tail of the G Protein-Coupled Vasopressin V2 Receptor are Necessary for Transport-Competent Receptor Folding
- The Ins and Outs of Aquaporin-2 Trafficking
- The Vasopressin Type 2 Receptor Gene. Chromosomal Localization and Its Role in Nephrogenic Diabetes Insipidus
- Therapeutic Potential of Vasopressin Receptor Antagonists
- Three Novel AVPR2 Mutations in Three Japanese Families with X-Linked Nephrogenic Diabetes Insipidus
- Two Novel Mutations in the Vasopressin V2 Receptor Gene in Unrelated Japanese Kindreds with Nephrogenic Diabetes Insipidus
- V2 Vasopressin Receptor Dysfunction in Nephrogenic Diabetes Insipidus Caused By Different Molecular Mechanisms
- Vasopressin Receptors in Health and Disease
- Vasopressin and Oxytocin Receptors
- Vasopressin-Independent Renal Urinary Concentration: Increased rBSC1 and Enhanced Countercurrent Multiplication
- Vasopressin-Sensitive Adenylate Cyclase: Subunit Interactions Assessed by Target Analysis and Computer Modelling
- Water Channels
Used in 46 Proceeding abstracts
Used in 46 Proceeding abstracts
- A Novel dominant mutation of the aquaporin-2 gene resulting in partial nephrogenic diabetes insipidus
- A pharmacological chaperone acting at the V2-vasopressin receptor offers a treatment for Nephrogenic Diabetes Insipidus
- A proposal for the building and maintenance of an AVPR2 molecular model database
- Action Mechanism of Pharmacological Chaperones Acting on the V2 Vasopressin Receptor in the Treatment of Nephrogenic Diabetes Insipidus
- Analysis of molecular mechanisms causing V2 vasopressin receptor dysfunction in four patients with X-linked nephrogenic diabetes insipidus
- Aquaporin 2-containing Apical Membrane Endosomes (AQP-2 Endosomes) Possess a Multiprotein Signaling Complex
- Biochemical Characterization of Partial Nephrogenic Diabetes Insipidus (NDI) Phenotypes
- Candesartan treatment prevents dysregulation of AQP2, BSC-1 and NaPi2 in ureteral obstruction-induced NDI
- Characterization of mutant vasopressin V2 receptors with a misfolded AVP binding site
- Clinical Data and Cell Biological Aspects of Mutations in Nephrogenic Diabetes Insipidus
- Clinical Phenotype and Molecular Characterization of A Mutant V2 Receptor Associated with Partial Congenital Nephrogenic Diabetes Insipidus
- Compartmentalization of NDI-causing vasopressin V2 receptor mutants in the early secretory pathway
- Diversity of Nephrogenic Diabetes Insipidus Mutations and Importance of Early Recognition and Treatment
- Dysregulation of genes in rats with lithium-induced NDI
- Functional rescue of three vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus by a second site suppressor mutation
- Functional rescue of truncated V2-Vasopressin-receptors by aminoglycoside-induced misreading of nonsense-mutations
- Functional studies of twelve mutant V2 vasopressin receptors related to nephrogenic diabetes insipidus: molecular basis of a mild clinical phenotype.
- G15 reveals coupling of the V2 receptor to PLC that is refractory to receptor desensitization
- GIP, a G protein coupled receptor interacting protein
- Hormone-regulated intrenalization of the vasopressin V2 receptor in a polarized renal collecting duct cell system
- Mutations of the vasopressin V2 receptor gene in X-linked Nephrogenic Diabetes Insipidus: functional analysis of receptor mutants and identification of new mutations in Italian families.
- Naturally occurring and in vitro mutations defining the role of the NPXXY motif in the vasopressin V2 receptor
- Nephrogenic Diabetes Insipidus Mutation Database
- Nephrogenic diabetes insipidus in Italian families
- O-Glycosylation of the V2 vasopressin receptor
- Pharmacological chaperones functionally rescue misfolded mutant V2 vasopressin receptors that cause nephrogenic diabetes insipidus
- Prostaglandins as Stimulants of AQP2 Expression: a Possible Future Treatment for NDI?
- Purinergic Control of Medullary Collecting Duct Function: A Novel Vasopressin-independent Regulatory Mechanism
- Recycling of the V2 Vasopressin Receptor
- Rediscovery of Swedish Kindred with X-linked 'Vasopressin-Responsive' Diabetes Insipidus: Validation and Explanation of the Unusual Clinical Phenotype
- Regulation of Aquaporin-2 trafficking by Vasopressin in Renal Collecting Duct: Roles of Ryanodine-Sensitive Ca2+ Stores and Calmodulin
- Structural evolution of the V2 vasopressin receptor in mammals
- Structure of V2 vasopressin receptor oligomers: evidence for contact dimer formation
- Structure-Function Analysis of the V2 Vasopressin Receptor
- Supplementation of Receptor Fragments: An approach to Functionally Rescue Mutant V2 Vasopressin Receptors
- The C-terminus as a determinant for vasopressin receptors sorting
- The Medical Geneticist's Perspective on NDI Research
- The last fifty years; a retrospective on NDI
- The novel Aquaporin-2 maturing protein 1 interacts with AQP2, inhibits its forskolin-induced translocation to the apical membrane, and reduces its expression
- Transport Defects of V2 Receptor Mutants Found in Patients with X-linked Nephrogenic Diabetes Insipidus
- V2 Vasopressin Receptors in NDI: Where did they go?
- V2 vasopressin receptor function studied in mice and yeast
- V2 vasopressin receptor mutants responsible for nephrogenic diabetes insipidus associate with the molecular chaperones calnexin and Hsp70
- V2 vasopressin receptor-arrestin interactions
- V2 vasopressin receptor-deficient mouse model: Pathophysiological changes and therapeutical implications
- Variations in clinical phenotype associated with different mutations of the V2 receptor gene in X-linked recessive congenital nephrogenic DI (xCNDI)
Used in 17 Proceeding translations
Used in 17 Proceeding translations
- Differences between ER-retained vasopressin V2 receptor mutants in antagonist-mediated restoration of cell surface expression
- Functional studies of twelve mutant V2 vasopressin receptors related to nephrogenic diabetes insipidus: molecular basis of a mild clinical phenotype.
- GIP, a G protein coupled receptor interacting protein
- O-Glycosylation of the V2 vasopressin receptor
- Pharmacological chaperones functionally rescue misfolded mutant V2 vasopressin receptors that cause nephrogenic diabetes insipidus
- Purinergic Control of Medullary Collecting Duct Function: A Novel Vasopressin-independent Regulatory Mechanism
- Quality control of nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants in the ER and in the ER/Golgi intermediate compartment
- Recycling of the V2 Vasopressin Receptor
- Regulation of Aquaporin-2 trafficking by Vasopressin in Renal Collecting Duct: Roles of Ryanodine-Sensitive Ca2+ Stores and Calmodulin
- Structural evolution of the V2 vasopressin receptor in mammals
- Structure of V2 vasopressin receptor oligomers: evidence for contact dimer formation
- Supplementation of Receptor Fragments: An approach to Functionally Rescue Mutant V2 Vasopressin Receptors
- The Medical Geneticist's Perspective on NDI Research
- The novel Aquaporin-2 maturing protein 1 interacts with AQP2, inhibits its forskolin-induced translocation to the apical membrane, and reduces its expression
- Transport Defects of V2 Receptor Mutants Found in Patients with X-linked Nephrogenic Diabetes Insipidus
- V2 vasopressin receptor mutants responsible for nephrogenic diabetes insipidus associate with the molecular chaperones calnexin and Hsp70
- V2 vasopressin receptor-arrestin interactions
Used in 62 Term definitions
Used in 62 Term definitions
- ß-adrenergic receptor
- 1-desamino-8-D-arginine vasopressin
- AVPR1b
- G protein-coupled receptors
- G-protein coupled receptors
- G-protein-coupled receptors
- GIP
- GPCR
- GPCR mutations
- H1 and H1
- H2
- NDI Abstract of Article: 539
- V1a arginine vasopressin receptor
- V1a vasopressin receptor
- V2 AVP receptor
- V2 receptor
- V2-receptor
- V2-tail
- a-adrenergic receptor
- adaptation
- afferent neuron
- affinity chromatography
- anesthesia
- antagonist
- antagonists
- antagonize
- beta-arrestin
- bind
- binding
- binds
- blockade
- bound
- carboxy
- carboxy-terminal V2 receptor fragment
- cell receptor
- cell-surface receptor
- cellular receptors
- chemoreceptor
- clathrin
- evoked potential
- extracellular receptor domains
- histamine1
- histamine2
- ligand
- ligands
- membrane protein
- mutant receptors
- nociceptor
- paracrine
- photoreceptor
- postreceptor
- primary sensory neuron
- protein kinase C
- receptors
- sense organ
- sensory receptors
- stimulus
- vasopressin 1A receptor
- vasopressin 1B receptor
- vasopressin receptor
- vasopressin-1a receptor
- vasopressin-1b receptor