suppressor cells
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- suppressor cells
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Differentiated T lymphocytes of the CD8 cells group that suppress antibody synthesis or cell-mediated immunity. They may be activated in response to antigen or to idiotypic determinants present on antibodies and T cell antigen receptors and B cell antigen receptors and may act either by suppressing activity of helper cells or by inhibiting the differentiation of activated lymphocytes into effector cells. Murine suppressor cells are marked by the Ly-2 and Ly-3 antigens, human suppressor cells by the CD5 and CD8 antigens.
Used in 4 Term definitions
Used in 4 Term definitions