water channel
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- water channel
-
A channel in the plasma membrane of plant and animal cells that permits passage of water molecules; chemical substances such as vasopressin cause the opening of new channels and increase permeability.
Used in 98 Article abstracts
Used in 98 Article abstracts
- A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial Cells
- An Impaired Routing of Wild-type Aquaporin-2 after Tetramerization with an Aquaporin-2 Mutant Explains Dominant Nephrogenic Diabetes Insipidus
- Apical Extracellular Calcium/Polyvalent Cation-sensing Receptor Regulates Vasopressin-elicited Water Permeability in Rat Kidney Inner Medullary Collecting Duct
- Aquaporin-2 Expression in Primary Cultured Rat Inner Medullary Collecting Duct Cells
- Aquaporin-2 Trafficking is Regulated by PDZ-domain Containing Protein SPA-1
- Aquaporin-2 Water Channel Mutations Causing Nephrogenic Diabetes Insipidus
- Aquaporin-2: COOH Terminus is Necessary But Not Sufficient for Routing to the Apical Membrane
- Aquaporins in the Kidney: From Molecules to Medicine
- Assignment of the Human Gene for the Water Channel of Renal Collecting Duct Aquaporin 2 (AQP2) to Chromosome 12 Region q12-->q13
- Bilateral Ureteral Obstruction Downregulates Expression of Vasopressin-Sensitive AQP-2 Water Channel in Rat Kidney
- CHIP28 Water Channels are Localized in Constitutively Water-Permeable Segments of the Nephron
- Cellular and Subcellular Localization of the Vasopressin-Regulated Urea Transporter in Rat Kidney
- Characterization of Purified Endosomes Containing the Antidiuretic Hormone-Sensitive Water Channel From Rat Renal Papilla
- Cloning and Expression of Apical Membrane Water Channel of Rat Kidney Collecting Tubule
- Cloning of an Aquaporin Homologue Present in Water Channel Containing Endosomes of Toad Urinary Bladder
- Cloning, Characterization, and Chromosomal Mapping of Human Aquaporin of Collecting Duct
- Compartmentalization of cAMP-Dependent Signaling by Phosphodiesterase-4D is Involved in the Regulation of Vasopressin-Mediated Water Reabsorption in Renal Principal Cells
- Concentrating Defect in Experimental Nephrotic Syndrome: Altered Expression of Aquaporins and Thick Ascending Limb Na+ Transporters
- Congestive Heart Failure in Rats is Associated with Increased Expression and Targeting of Aquaporin-2 Water Channel in Collecting Duct
- Constitutive and Regulated Membrane Expression of Aquaporin 1 and Aquaporin 2 Water Channels in Stably Transfected LLC-PK1 Epithelial Cells
- Cyclooxygenase-2 Inhibitor Preserves Medullary Aquaporin-2 Expression and Prevents Polyuria After Ureteral Obstruction
- Decreased Vasopressin-Mediated Renal Water Reabsorption in Rats with Compensated Liver Cirrhosis
- Detection of aquaporin-2 in the plasma membranes of oocytes: a novel isolation method with improved yield and purity.
- Development of Urinary Concentrating Capacity: Role of Aquaporin-2
- Diabetes Insipidus (Hendy, Bichet)
- Diffusion in the Endoplasmic Reticulum of an Aquaporin-2 Mutant Causing Human Nephrogenic Diabetes Insipidus
- Disordered Water Channel Expression and Distribution in Acquired Nephrogenic Diabetes Insipidus
- Downregulation of Renal Vasopressin V2 Receptor and Aquaporin-2 Expression Parallels Age-Associated Defects in Urine Concentration
- Dual Influence of Aldosterone on AQP2 Expression in Cultured Renal Collecting Duct Principal Cells
- Escape from Vasopressin-Induced Antidiuresis: Role of Vasopressin Resistance of the Collecting Duct
- Evidence for Stabilization of Aquaporin-2 Folding Mutants by N-linked Glycosylation in the Endoplasmic Reticulum
- Functional Analysis of Aquaporin-2 Mutants Associated with Nephrogenic Diabetes Insipidus by Yeast Expression
- High Proton Flux through Membranes Containing Antidiuretic Hormone Water Channels
- Hypertonicity Regulates the Aquaporin-2 Promoter Independently of Arginine Vasopressin
- Hypokalemia-Induced Downregulation of Aquaporin-2 Water Channel Expression in Rat Kidney Medulla and Cortex
- Identification of Rab3-, Rab5a- and Synaptobrevin II-like Proteins in a Preparation of Rat Kidney Vesicles Containing the Vasopressin-Regulated Water Channel
- Identification of a Multiprotein "Motor" Complex Binding to Water Channel Aquaporin-2
- Identification of a Novel A-kinase Anchoring Protein 18 Isoform and Evidence for its Role in the Vasopressin-induced Aquaporin-2 Shuttle in Renal Principal Cells
- Impaired Aquaporin and Urea Transporter Expression in Rats with Adriamycin-Induced Nephrotic Syndrome
- Importance of Aquaporin-2 Expression Levels in Genotype -Phenotype Studies in Nephrogenic Diabetes Insipidus
- Kinetics of Urea and Water Permeability Activation by Vasopressin in Rat Terminal IMCD
- Large-Scale Purification of Functional Recombinant Human Aquaporin-2
- Lithium-induced Down regulation of Aquaporin-2 Water Channel Expression in Rat Kidney Medulla
- Long Term Regulation of Aquaporin-2 Expression in Vasopressin-responsive Renal Collecting Duct Principal Cells
- Loss of Calcineurin Aα Results in Altered Trafficking of AQP2 and in Nephrogenic Diabetes Insipidus
- Mechanisms and Regulation of Water Permeability in Renal Epithelia
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular Analyses of the Vasopressin Type 2 Receptor and Aquaporin-2 Genes in Brazilian Kindreds with Nephrogenic Diabetes Insipidus
- Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking
- Neonatal Mortality in an Aquaporin-2 Knock-in Mouse Model of Recessive Nephrogenic Diabetes Insipidus
- Nephrogenic Diabetes Insipidus in Mice Lacking Aquaporin-3 Water Channels
- New Mutations in the AQP2 Gene in Nephrogenic Diabetes Insipidus Resulting in Functional but Misrouted Water Channels
- Novel Mutations in Aquaporin-2 Gene in Female Siblings with Nephrogenic Diabetes Insipidus: Evidence of Disrupted Water Channel Function
- Novel Vasopressin Type 2 (AVPR2) Gene Mutations in Brazilian Nephrogenic Diabetes Insipidus Patients
- Oxytocin Induces Apical and Basolateral Redistribution of Aquaporin-2 in Rat Kidney
- Pathophysiology of Aquaporin-2 in Water Balance Disorders
- Phenotypes Developed in Secretin Receptor-Null Mice Indicated a Role for Secretin in Regulating Renal Water Reabsorption
- Phosphorylation of Aquaporin-2 does not alter the Membrane Water Permeability of Rat Papillary Water Channel-containing Vesicles
- Physiology and Pathophysiology of the Aquaporin-2 Water Channel
- Purification and Partial Characterization of Candidate Antidiuretic Hormone Water Channel Proteins of Mr 55,000 and 53,000 from Toad Urinary Bladder
- Quantitation and Topography of Membrane Proteins in Highly Water-Permeable Vesicles From ADH-Stimulated Toad Bladder
- Quantitation of Aquaporin-2 Abundance in Microdissected Collecting Ducts: Axial Distribution and Control by AVP
- Rat Renal Arcade Segment Expresses Vasopressin-regulated Water Channel and Vasopressin V2 Receptor
- Reconstitution of a Regulated Transepithelial Water Pathway in Cells Transfected with AQP2 and an AQP1/AQP2 Hybrid Containing the AQP2-C Terminus
- Redistribution of Aquaporin-2 Water Channels Induced by Vasopressin in Rat Kidney Inner Medullary Collecting Duct
- Regulation of Collecting Duct Water Channel Expression by Vasopressin in Brattleboro Rat
- Renal Aquaporins
- Renal Aquaporins: Key Roles in Water Balance and Water Balance Disorders
- Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-Dependent Concentration of Urine
- Reversed Polarized Delivery of an Aquaporin-2 Mutant Causes Dominant Nephrogenic Diabetes Insipidus
- Rho Inhibits cAMP-Induced Translocation of Aquaporin-2 into the Apical Membrane of Renal Cells
- Role of Aquaporins in Water Balance Disorders
- Role of the Cytoplasmic Termini in the Sorting and Shuttling of the Aquaporin-2 Water Channel
- Routing of the aquaporin-2 water channel in health and disease.
- Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels
- Stimulation of AQP2 Membrane Insertion in Renal Epithelial Cells In Vitro and In Vivo by the cGMP Phosphodiesterase Inhibitor Sildenafil Citrate (Viagra)
- Structure and Function of Kidney Water Channels
- The Ins and Outs of Aquaporin-2 Trafficking
- The Molecular Basis of Nephrogenic Diabetes Insipidus
- The Proteasome is Involved in the Degradation of Different Aquaporin-2 Mutants Causing Nephrogenic Diabetes Insipidus
- Three Families with Autosomal Dominant Nephrogenic Diabetes Insipidus Caused by Aquaporin-2 Mutations in the C-terminus
- Two Novel Aquaporin-2 Mutations Responsible for Congenital Nephrogenic Diabetes Insipidus in Chinese Families
- Upregulation of Urea Transporter UT-A2 and Water Channels AQP2 and AQP3 in Mice Lacking Urea Transporter UT-B
- Urea Transporter UT-A1 and Aquaporin-2 Proteins Decrease in Response to Angiotensin II or Norepinephrine-Induced Acute Hypertension
- Urinary Excretion of Aquaporin-2 in Term and Preterm Infants
- Vasopressin Activates Collecting Duct Urea Transporters and Water Channels by Distinct Physical Processes
- Vasopressin Increases Water Permeability of Kidney Collecting Duct by Inducing Translocation of Aquaporin-CD Water Channels to Plasma Membrane
- Vasopressin Receptors in Health and Disease
- Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus
- Water Channel Aquaporin-2 Directly Binds to Actin
- Water Channels Encoded by Mutant Aquaporin-2 Genes in Nephrogenic Diabetes Insipidus are Impaired in Their Cellular Routing
- Water Channels and Urea Transporters
- Water Transport Across Mammalian Cell Membranes
- [Congenital Diabetes Insipidus. Recent Advances in Molecular Genetics] (French)
- [Hereditary Nephrogenic Diabetes Insipidus] (French)
- [Nephrogenic Diabetes Insipidus] (Japanese)
- [Pathological Aspects of Water Transport in the Collecting Ducts] (French)
- cDNA Cloning of a Functional Water Channel From Toad Urinary Bladder Epithelium
Used in 34 Article translations
Used in 34 Article translations
- Activation of the Vasopressin-sensitive Water Permeability Pathway in the Toad Bladder by N-ethyl Maleimide
- Antidiuretic Hormone Modulates Membrane Phosphoproteins in Toad Urinary Bladder and Retrieved Water Channel Containing Apical Membrane Vesicles
- Aquaporins: From Physiology to Nephrogenic Diabetes Insipidus
- Assignment of the Human Gene for the Water Channel of Renal Collecting Duct Aquaporin 2 (AQP2) to Chromosome 12 Region q12-->q13
- Cloning of an Aquaporin Homologue Present in Water Channel Containing Endosomes of Toad Urinary Bladder
- Cloning, Characterization, and Chromosomal Mapping of Human Aquaporin of Collecting Duct
- Compartmentalization of cAMP-Dependent Signaling by Phosphodiesterase-4D is Involved in the Regulation of Vasopressin-Mediated Water Reabsorption in Renal Principal Cells
- Current Understanding of the Cellular Biology and Molecular Structure of the Antidiuretic Hormone-stimulated Water Transport Pathway
- Downregulation of Aquaporin-2 Parallels Changes in Renal Water Excretion in Unilateral Ureteral Obstruction
- Endosomes from Kidney Collecting Tubule Cells Contain the Vasopressin-sensitive Water Channel
- Functional Water Channels Are Present in Clathrin-coated Vesicles from Bovine Kidney but Not from Brain
- Heat Shock Protein 70 Interacts with Aquaporin-2 (AQP2) and Regulates Its Trafficking
- Heteroligomerization of an Aquaporin-2 Mutant with Wild-Type Aquaporin-2 and Their Misrouting to Late Endosomes/Lysosomes Explains Dominant Nephrogenic Diabetes Insipidus
- Identification of Rab3-, Rab5a- and Synaptobrevin II-like Proteins in a Preparation of Rat Kidney Vesicles Containing the Vasopressin-Regulated Water Channel
- Indomethacin Enhances Shuttling of Aquaporin-2 Despite Decreased Abundance in Rat Kidney
- Mechanisms and Regulation of Water Permeability in Renal Epithelia
- Mechanisms and Regulation of Water Transport in the Kidney
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular Aspects of Water Transport
- Phenotypes Developed in Secretin Receptor-Null Mice Indicated a Role for Secretin in Regulating Renal Water Reabsorption
- Phosphorylation of Aquaporin-2 does not alter the Membrane Water Permeability of Rat Papillary Water Channel-containing Vesicles
- Regulation of Collecting Duct Water Channel Expression by Vasopressin in Brattleboro Rat
- Relationship Between Vasopressin-Sensitive Water Transport and Plasma Membrane Fluidity in Kidney Collecting Tubule
- Renal Aquaporins
- Reversed Polarized Delivery of an Aquaporin-2 Mutant Causes Dominant Nephrogenic Diabetes Insipidus
- Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels
- Structure and Function of Kidney Water Channels
- The Aquaporin Family of Water Channels in Kidney: an Update on Physiology and Pathophysiology of Aquaporin-2
- The Role of Membrane Turnover in the Water Permeability Response to Antidiuretic Hormone
- Vasopressin Receptors in Health and Disease
- Water Channels and Urea Transporters
- Water Channels in Cell Membranes
- Water Transport Across Mammalian Cell Membranes
- cDNA Cloning of a Functional Water Channel From Toad Urinary Bladder Epithelium
Used in 30 Proceeding abstracts
Used in 30 Proceeding abstracts
- An impaired routing of wild type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
- Aquaporin 2-containing Apical Membrane Endosomes (AQP-2 Endosomes) Possess a Multiprotein Signaling Complex
- Aquaporin-2 Expression in Primary Cultures of Rat Inner Medullary Collecting Duct Cells - A New In-Vitro Model System Facilitating the Study of the Vasopressin-Regulated Antidiuretic Machinery at the Cellular Level
- Contribution of chloride channels in urine concentrating ability
- Decreased Aquaporin-2 Water Channel Expression in Acquired Nephrogenic Diabetes Insipidus
- Determination of the functionality of AQP2 missense mutants in recessive NDI
- Expressional alteration of sodium transporter in the thick ascending limb of Henle and urinary concentration
- Gene Mutation Analysis of NDI patients in Japan
- Generation of Germ Line Heterozygous Mice for Aquaporin-2 Conditional Knock-Out and Knock-In Models of NDI
- Identification of proteins involved in the vasopressin-induced shuttle of aquaporin-2
- Identification of sequence determinants that direct different intracellular folding pathways for kidney aquaporins
- Lithium-induced Nephrogenic Diabetes Insipidus: A Cell Culture Model
- Molecular mechanisms underlying dominant Nephrogenic Diabetes Insipidus caused by mutations in the AQP2 gene
- Nephrogenic Diabetes Insipidus Mutation Database
- Nephrogenic Diabetes Insipidus in mice lacking aquaporin-3 water channels
- Obstructive nephropathy -- a common acquired condition of nephrogenic diabetes insipidus
- Osmolality and solute composition regulate aquaporin-2 expression in primary cultured renal principal cells
- Phenotype of aquaporin knockout mice, and AQP2 misprocessing in NDI
- Production and purification of Aquaporin-2 and Vasopressin 2 Receptor: towards elucidation of the structure
- Protein Kinase C involvement in aquaporin-2 endocytosis in cell culture
- Proteomic Studies of Vasopressin Action in the Collecting Duct
- Regulation of AQP2 trafficking and recycling by dopamine, PGE2 and ANP: involvement of AQP2-S256 phosphorylation
- Role of phosphorylation in the trafficking and shuttling of the Aquaporin-2 water channel
- Routing and function of mutant AQP2 water channels in nephrogenic diabetes insipidus
- The novel Aquaporin-2 maturing protein 1 interacts with AQP2, inhibits its forskolin-induced translocation to the apical membrane, and reduces its expression
- The stoichiometry of phosphorylated and non-phosphorylated monomers in an aquaporin-2 tetramer determines its subcellular localization
- Urinary Aquaporin-2 in Diagnosis of Disorders of Water Metabolism
- Vasopressin-V2-receptor dependent and independent regulation of collecting duct aquaporin-2 expression and trafficking
- Vasopressin-induced / cyclic AMP-mediated aquaporin 2 translocation is a Ca2+-independent, slow exocytotic process
- Wild-type aquaporin-2 rescues a novel aquaporin-2 mutant in recessive Nephrogenic Diabetes Insipidus to the apical plasma membrane
Used in 7 Proceeding translations
Used in 7 Proceeding translations
- An impaired routing of wild type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
- Clinical Data and Cell Biological Aspects of Mutations in Nephrogenic Diabetes Insipidus
- Functional investigations of the vasopressin regulated antidiuretic machinery in single inner medullary collecting duct (IMCD) cells
- Molecular mechanisms underlying dominant Nephrogenic Diabetes Insipidus caused by mutations in the AQP2 gene
- Proteomic Studies of Vasopressin Action in the Collecting Duct
- Purinergic Control of Medullary Collecting Duct Function: A Novel Vasopressin-independent Regulatory Mechanism
- Routing and function of mutant AQP2 water channels in nephrogenic diabetes insipidus