The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.

DEFINITION:

hypertrophic pulmonary osteoarthropathy

Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the more distal long bones, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint abnormalities. It is often secondary to chronic conditions of the lungs and heart. Called also "hyperplastic osteoarthritis," "Marie-Bamberger disease" or "Marie-Bamberger syndrome," "pulmonary osteoarthropathy," and "secondary hypertrophic osteoarthropathy."