coenzyme A
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- coenzyme A
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A coenzyme in which phosphorylated pantothenic acid is covalently linked to ß-mercaptoethylamine and adenosine 3',5'-bisphosphate. The terminal thiol group of the ß-mercaptoethanolamine is enzymatically acylated to form high-energy thiol ester compounds such as the acetyl, acetoacetyl, and long chain fatty acid (acyl) compounds. These thiol esters play a central role in various metabolic reactions, e.g., the tricarboxylic acid cycle, the transfer of acetyl groups, and the oxidation of fatty acids. Abbreviated CoA and CoA-SH.
Used in 4 Term definitions
Used in 4 Term definitions