cytomegalic inclusion disease
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- cytomegalic inclusion disease
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Any of a group of diseases caused by cytomegalovirus infection marked by characteristic inclusion bodies in enlarged infected cells. The classic disease is congenital, being acquired in utero from the mother; infection can also be transmitted from mother to infant in passage through the birth canal or from ingestion of the virus present in the mother's milk. Most infected infants are asymptomatic, but in some hepatosplenomegaly, jaundice, chorioretinitis, purpura, microcephaly, cerebral calcifications, and severe central nervous system sequelae resulting in blindness, deafness, quadriplegia, and mental retardation may occur. Acquired disease is transmitted via respiratory droplets or tissue or blood donation, or it may be sexually transmitted. The group also includes an infectious mononucleosis-like syndrome in previously well individuals and in those receiving multiple blood transfusions and a disseminated, sometimes fatal, infection in immunocompromised patients.
Used in 1 Term definition
Used in 1 Term definition