delayed hypersensitivity reaction
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- delayed hypersensitivity reaction
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A reaction of cell -mediated immunity, named in contrast to immediate hypersensitivity reactions because its onset is 24 to 72 hours after the antigenic challenge; the term is usually used to denote the subset of type IV hypersensitivity reactions involving cytokine release and macrophage activation, as opposed to direct cytolysis, but can be used more broadly, even sometimes being used synonymously with type IV hypersensitivity reaction. The classic delayed hypersensitivity reaction is the tuberculin reaction observed in skin testing.
Used in 1 Term definition
Used in 1 Term definition