endoplasmic reticulum
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- endoplasmic reticulum
Used in 43 Article abstracts
Used in 43 Article abstracts
- A Dileucine Sequence and an Upstream Glutamate Residue in the Intracellular Carboxyl Terminus of the Vasopressin V2 Receptor are Essential for Cell Surface Transport in COS.M6 Cells
- A Novel Mechanism in Recessive Nephrogenic Diabetes Insipidus: Wild-Type Aquaporin-2 Rescues the Apical Membrane Expression of Intracellularly Retained AQP2-P262L
- An Aquaporin-2 Water Channel Mutant Which Causes Autosomal Dominant Nephrogenic Diabetes Insipidus is Retained in the Golgi Complex
- An Impaired Routing of Wild-type Aquaporin-2 after Tetramerization with an Aquaporin-2 Mutant Explains Dominant Nephrogenic Diabetes Insipidus
- An X-linked NDI Mutation Reveals a Requirement for Cell Surface V2R Expression
- Association of Calnexin With Wild Type and Mutant AVPR2 that Cause Nephrogenic Diabetes Insipidus
- Cell-Biologic and Functional Analyses of Five New Aquaporin-2 Missense Mutations that Cause Recessive Nephrogenic Diabetes Insipidus
- Characterization of Vasopressin V2 Receptor Mutants in Nephrogenic Diabetes Insipidus in a Polarized Cell Model
- Characterization of an Aquaporin-2 Water Channel Gene Mutation Causing Partial Nephrogenic Diabetes Insipidus in a Mexican Family: Evidence of Increased Frequency of the Mutation in the Town of Origin
- Defective Aquaporin-2 Trafficking in Nephrogenic Diabetes Insipidus and Correction by Chemical Chaperones
- Defective processing and trafficking of water channels in nephrogenic diabetes insipidus.
- Diffusion in the Endoplasmic Reticulum of an Aquaporin-2 Mutant Causing Human Nephrogenic Diabetes Insipidus
- Disease-Causing V2 Vasopressin Receptors are Retained in Different Compartments of the Early Secretory Pathway
- Evidence for Stabilization of Aquaporin-2 Folding Mutants by N-linked Glycosylation in the Endoplasmic Reticulum
- Folding and Cell Surface Expression of the Vasopressin V2 Receptor: Requirement of the Intracellular C-terminus
- Functional Rescue of Vasopressin V2 Receptor Mutants in MDCK Cells by Pharmacochaperones: Relevance to Therapy of Nephrogenic Diabetes Insipidus
- Genetics of Vasopressin Receptors
- Glycosylation is Important for Cell Surface Expression of the Water Channel Aquaporin-2, But is Not Essential for Tetramerization in the Endoplasmic Reticulum
- Identification and Characterization of Aquaporin-2 Water Channel Mutations Causing Nephrogenic Diabetes Insipidus with Partial Vasopressin Response
- Importance of Aquaporin-2 Expression Levels in Genotype -Phenotype Studies in Nephrogenic Diabetes Insipidus
- Importance of the Mercury-Sensitive Cysteine on Function and Routing of AQP1 and AQP2 in Oocytes
- Investigation of Folding and Degradation of In Vitro Synthesized Mutant Proteins in Microsomes
- Membrane Targeting and Determination of Transmembrane Topology of the Human Vasopressin V2 Receptor
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular and Cellular Defects in Nephrogenic Diabetes Insipidus (Knoers, Deen)
- Neonatal Mortality in an Aquaporin-2 Knock-in Mouse Model of Recessive Nephrogenic Diabetes Insipidus
- New Mutations in the AQP2 Gene in Nephrogenic Diabetes Insipidus Resulting in Functional but Misrouted Water Channels
- Pharmacochaperones Post-Translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-Type and Mutant Vasopressin V2 Receptors
- Pharmacologic Chaperones as a Potential Treatment for X-linked Nephrogenic Diabetes Insipidus
- Pharmacological Chaperones in Nephrogenic Diabetes Insipidus: Possibilities for Clinical Application
- Relief of Nocturnal Enuresis by Desmopressin is Kidney and Vasopressin Type 2 Receptor Independent
- Rescue of Vasopressin V2 Receptor Mutants by Chemical Chaperones: Specificity and Mechanism
- Rescue of a Nephrogenic Diabetes Insipidus-Causing Vasopressin V2 Receptor Mutant by Cell-Penetrating Peptides
- Role of Aquaporin Water Channels in Kidney and Lung
- Ser-256 Phosphorylation Dynamics of Aquaporin 2 During Maturation From the Endoplasmic Reticulum to the Vesicular Compartment in Renal Cells
- Sorting Functions of the Individual Cytoplasmic Domains of the G Protein-Coupled Vasopressin V2 Receptor in Madin Darby Canine Kidney Epithelial Cells
- The C-Terminal Tail of Aquaporin-2 Determines Apical Trafficking
- The Hydrophobic Amino Acid Residues in the Membrane-Proximal C Tail of the G Protein-Coupled Vasopressin V2 Receptor are Necessary for Transport-Competent Receptor Folding
- The Proteasome is Involved in the Degradation of Different Aquaporin-2 Mutants Causing Nephrogenic Diabetes Insipidus
- Variant Amino Acids in the Extracellular Loops of Murine and Human Vasopressin V2 Receptors Account for Differences in Cell Surface Expression and Ligand Affinity
- Vasopressin V2 Receptor Mutants that Cause X-linked Nephrogenic Diabetes Insipidus: Analysis of Expression, Processing, and Function
- Water Channels Encoded by Mutant Aquaporin-2 Genes in Nephrogenic Diabetes Insipidus are Impaired in Their Cellular Routing
- cDNA and Genomic Cloning of Mouse Aquaporin-2: Functional Analysis of an Orthologous Mutant Causing Nephrogenic Diabetes Insipidus
Used in 45 Article translations
Used in 45 Article translations
- A Dileucine Sequence and an Upstream Glutamate Residue in the Intracellular Carboxyl Terminus of the Vasopressin V2 Receptor are Essential for Cell Surface Transport in COS.M6 Cells
- A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial Cells
- A Novel Mechanism in Recessive Nephrogenic Diabetes Insipidus: Wild-Type Aquaporin-2 Rescues the Apical Membrane Expression of Intracellularly Retained AQP2-P262L
- An Aquaporin-2 Water Channel Mutant Which Causes Autosomal Dominant Nephrogenic Diabetes Insipidus is Retained in the Golgi Complex
- An Impaired Routing of Wild-type Aquaporin-2 after Tetramerization with an Aquaporin-2 Mutant Explains Dominant Nephrogenic Diabetes Insipidus
- An X-linked NDI Mutation Reveals a Requirement for Cell Surface V2R Expression
- Aquaporin-2 Water Channel Mutations and Nephrogenic Diabetes Insipidus: New Variations on a Theme
- Association of Calnexin With Wild Type and Mutant AVPR2 that Cause Nephrogenic Diabetes Insipidus
- Characterization of Vasopressin V2 Receptor Mutants in Nephrogenic Diabetes Insipidus in a Polarized Cell Model
- Characterization of an Aquaporin-2 Water Channel Gene Mutation Causing Partial Nephrogenic Diabetes Insipidus in a Mexican Family: Evidence of Increased Frequency of the Mutation in the Town of Origin
- Defective Aquaporin-2 Trafficking in Nephrogenic Diabetes Insipidus and Correction by Chemical Chaperones
- Disease-Causing V2 Vasopressin Receptors are Retained in Different Compartments of the Early Secretory Pathway
- Evidence for Stabilization of Aquaporin-2 Folding Mutants by N-linked Glycosylation in the Endoplasmic Reticulum
- Functional Rescue of Mutant V2 Vasopressin Receptors Causing Nephrogenic Diabetes Insipidus by a Co-Expressed Receptor Polypeptide
- Functional Rescue of Vasopressin V2 Receptor Mutants in MDCK Cells by Pharmacochaperones: Relevance to Therapy of Nephrogenic Diabetes Insipidus
- Functional Rescue of the Constitutively Internalized V2 Vasopressin Receptor Mutant R137H by the Pharmacological Chaperone Action of SR49059
- Identification and Characterization of Aquaporin-2 Water Channel Mutations Causing Nephrogenic Diabetes Insipidus with Partial Vasopressin Response
- Importance of the Mercury-Sensitive Cysteine on Function and Routing of AQP1 and AQP2 in Oocytes
- Membrane Targeting and Determination of Transmembrane Topology of the Human Vasopressin V2 Receptor
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular Genetic Study of Congenital Nephrogenic Diabetes Insipidus and Rescue of Mutant Vasopressin V2 Receptor by Chemical Chaperones
- Nephrogenic Diabetes Insipidus (Bichet - November 1998)
- Nephrogenic Diabetes Insipidus. A V2 Vasopressin Receptor Unable to Stimulate Adenylyl Cyclase
- Nephrogenic Diabetes Insipidus: Causes Revealed
- New Mutations in the AQP2 Gene in Nephrogenic Diabetes Insipidus Resulting in Functional but Misrouted Water Channels
- Pharmacochaperones Post-Translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-Type and Mutant Vasopressin V2 Receptors
- Pharmacologic Chaperones as a Potential Treatment for X-linked Nephrogenic Diabetes Insipidus
- Pharmacological Chaperones Rescue Cell-Surface Expression and Function of Misfolded V2 Vasopressin Receptor Mutants
- Pharmacological Chaperones in Nephrogenic Diabetes Insipidus: Possibilities for Clinical Application
- Pharmacological Chaperones: Potential Treatment for Conformational Diseases
- Physiology and Pathophysiology of the Aquaporin-2 Water Channel
- Properties of the Human Arginine Vasopressin V2 Receptor after Site-Directed Mutagenesis of its Putative Palmitoylation Site
- Rescue of Vasopressin V2 Receptor Mutants by Chemical Chaperones: Specificity and Mechanism
- Rescue of a Nephrogenic Diabetes Insipidus-Causing Vasopressin V2 Receptor Mutant by Cell-Penetrating Peptides
- Role of Aquaporin Water Channels in Kidney and Lung
- The Hydrophobic Amino Acid Residues in the Membrane-Proximal C Tail of the G Protein-Coupled Vasopressin V2 Receptor are Necessary for Transport-Competent Receptor Folding
- The Molecular Basis of Nephrogenic Diabetes Insipidus
- The Proteasome is Involved in the Degradation of Different Aquaporin-2 Mutants Causing Nephrogenic Diabetes Insipidus
- The Vasopressin Type 2 Receptor Gene. Chromosomal Localization and Its Role in Nephrogenic Diabetes Insipidus
- Therapeutic Potential of Vasopressin Receptor Antagonists
- Two Novel Aquaporin-2 Mutations Responsible for Congenital Nephrogenic Diabetes Insipidus in Chinese Families
- V2 Vasopressin Receptor Dysfunction in Nephrogenic Diabetes Insipidus Caused By Different Molecular Mechanisms
- Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus
- Water Channels Encoded by Mutant Aquaporin-2 Genes in Nephrogenic Diabetes Insipidus are Impaired in Their Cellular Routing
- cDNA and Genomic Cloning of Mouse Aquaporin-2: Functional Analysis of an Orthologous Mutant Causing Nephrogenic Diabetes Insipidus
Used in 24 Proceeding abstracts
Used in 24 Proceeding abstracts
- Rescue of the Cell Surface Expression of Vasopressin V2 Receptor Mutants in Nephrogenic Diabetes Insipidus
- Action Mechanism of Pharmacological Chaperones Acting on the V2 Vasopressin Receptor in the Treatment of Nephrogenic Diabetes Insipidus
- An impaired routing of wild type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
- Cell biological and functional analysis of five new Aquaporin-2 gene missense mutations in recessive Nephrogenic Diabetes Insipidus
- Characterization of mutant vasopressin V2 receptors with a misfolded AVP binding site
- Chemical Chaperones as a Novel Therapeutic Strategy for NDI
- Clinical Data and Cell Biological Aspects of Mutations in Nephrogenic Diabetes Insipidus
- Clinical Phenotype and Molecular Characterization of A Mutant V2 Receptor Associated with Partial Congenital Nephrogenic Diabetes Insipidus
- Comparative analysis of human and murine vasopressin V2 receptor genes and their encoded proteins reveal striking differences in their genomic structure and functional properties
- Compartmentalization of NDI-causing vasopressin V2 receptor mutants in the early secretory pathway
- Consequences of tetramerization and expression levels of Aquaporin-2 in phenotype-genotype correlation studies in autosomal NDI
- Determination of the functionality of AQP2 missense mutants in recessive NDI
- Identification of sequence determinants that direct different intracellular folding pathways for kidney aquaporins
- Molecular mechanisms underlying dominant Nephrogenic Diabetes Insipidus caused by mutations in the AQP2 gene
- N-linked glycosylation is essential for transport of the Aquaporin-2 water channel to the plasma membrane in MDCK cells
- New insights in water channel physiology revealed by transgenic mouse models
- Pharmacological Chaperones Functionally Rescue Misfolded V2-Vasopressin Receptor Mutants that Cause Nephrogenic Diabetes Insipidus: Potential Clinical Implications
- Phenotype of aquaporin knockout mice, and AQP2 misprocessing in NDI
- Quality control of nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants in the ER and in the ER/Golgi intermediate compartment
- Role of phosphorylation in the trafficking and shuttling of the Aquaporin-2 water channel
- Routing and function of mutant AQP2 water channels in nephrogenic diabetes insipidus
- Toward a mouse model of human non-X-linked NDI
- Transport Defects of V2 Receptor Mutants Found in Patients with X-linked Nephrogenic Diabetes Insipidus
- Wild-type aquaporin-2 rescues a novel aquaporin-2 mutant in recessive Nephrogenic Diabetes Insipidus to the apical plasma membrane
Used in 16 Proceeding translations
Used in 16 Proceeding translations
- Rescue of the Cell Surface Expression of Vasopressin V2 Receptor Mutants in Nephrogenic Diabetes Insipidus
- A defect in AQP2 phosphorylation at Ser256 in the Golgi apparatus might explain the molecular basis of the dominant form of NDI caused by the mutation E258K-AQP2
- Action Mechanism of Pharmacological Chaperones Acting on the V2 Vasopressin Receptor in the Treatment of Nephrogenic Diabetes Insipidus
- An impaired routing of wild type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
- Cell biological and functional analysis of five new Aquaporin-2 gene missense mutations in recessive Nephrogenic Diabetes Insipidus
- Characterization of mutant vasopressin V2 receptors with a misfolded AVP binding site
- Comparative analysis of human and murine vasopressin V2 receptor genes and their encoded proteins reveal striking differences in their genomic structure and functional properties
- Compartmentalization of NDI-causing vasopressin V2 receptor mutants in the early secretory pathway
- Determination of the functionality of AQP2 missense mutants in recessive NDI
- Differences between ER-retained vasopressin V2 receptor mutants in antagonist-mediated restoration of cell surface expression
- New insights in water channel physiology revealed by transgenic mouse models
- Pharmacological Chaperones Functionally Rescue Misfolded V2-Vasopressin Receptor Mutants that Cause Nephrogenic Diabetes Insipidus: Potential Clinical Implications
- Quality control of nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants in the ER and in the ER/Golgi intermediate compartment
- Routing and function of mutant AQP2 water channels in nephrogenic diabetes insipidus
- Transport Defects of V2 Receptor Mutants Found in Patients with X-linked Nephrogenic Diabetes Insipidus
- Wild-type aquaporin-2 rescues a novel aquaporin-2 mutant in recessive Nephrogenic Diabetes Insipidus to the apical plasma membrane