Fc
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- Fc
-
(Fragment, crystallizable) - Originally, the fragment, not containing antigen combining sites, obtained by papain cleavage of the IgG molecule; now generally used as an adjective, e.g., Fc region, segment, to refer to the part of any immunoglobulin monomer comprising the hinge region and CH2, CH3 and CH4 domains of both heavy chains. The Fc region contains the allotypic markers and mediates all biologic activities including complement activation, binding to cell-surface receptors (Fc receptors, IgE receptors), and transplacental transport of IgG.
Used in 1 Article body
Used in 1 Article body