function
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- function
-
1. The special, normal, or proper physiologic activity of an organ or part.
2. To perform such activity.
3. In chemistry, a characteristic behavior of a chemical compound due to the presence of a specific functional group.
Used in 88 Article abstracts
Used in 88 Article abstracts
- A Mouse Model to Test the in vivo Efficacy of Chemical Chaperones
- A New Series of Photoactivatable and Iodinatable Linear Vasopressin Antagonists
- AVPR2 Variants and V2 Vasopressin Receptor Function in Nephrogenic Diabetes Insipidus
- Aminoglycoside Pretreatment Partially Restores the Function of Truncated V2 Vasopressin Receptors Found in Patients with Nephrogenic Diabetes Insipidus
- An Impaired Routing of Wild-type Aquaporin-2 after Tetramerization with an Aquaporin-2 Mutant Explains Dominant Nephrogenic Diabetes Insipidus
- An X-linked NDI Mutation Reveals a Requirement for Cell Surface V2R Expression
- Antidiuretic Hormone Modulates Membrane Phosphoproteins in Toad Urinary Bladder and Retrieved Water Channel Containing Apical Membrane Vesicles
- Apical Membrane Vesicles of ADH-stimulated Toad Bladder are Highly Water Permeable
- Aquaporins in the Kidney: From Molecules to Medicine
- Aquaporins: From Physiology to Nephrogenic Diabetes Insipidus
- Aquaporins: Roles in Renal Function and Peritoneal Dialysis
- Bladder Function Impairment in Aquaporin-2 Defective Nephrogenic Diabetes Insipidus
- Cell-Biologic and Functional Analyses of Five New Aquaporin-2 Missense Mutations that Cause Recessive Nephrogenic Diabetes Insipidus
- Central Diabetes Insipidus in a Dog with a Pro-Opiomelanocortin-Producing Pituitary Tumor not Causing Hyperadrenocorticism
- Clinical Characteristics of Eight Patients with Congenital Nephrogenic Diabetes Insipidus
- Compound Deletion of the rhoGAP C1 and V2 Vasopressin Receptor Genes in a Patient with Nephrogenic Diabetes Insipidus
- Concentration of Solutes in the Renal Inner Medulla: Interstitial Hyaluronan as a Mechano-Osmotic Transducer
- Cyclic AMP is Sufficient for Triggering the Exocytic Recruitment of Aquaporin-2 in Renal Epithelial Cells
- Diabetes Insipidus (Hendy, Bichet)
- Diabetes Insipidus in Uricase-Deficient Mice: A Model for Evaluating Therapy with Poly(Ethylene Glycol)-Modified Uricase
- Differential Diagnosis of Polyuria
- Dipsogenic Diabetes Insipidus: A Newly Recognized Syndrome Caused by a Selective Defect in the Osmoregulation of Thirst
- Endocytosis in Renal Proximal Tubules. Experimental Electron Microscopical Studies of Protein Absorption and Membrane Traffic in Isolated, In Vitro Perfused Proximal Tubules
- Evidence for a Role of Protein Kinase C-a in Urine Concentration
- Folding and Cell Surface Expression of the Vasopressin V2 Receptor: Requirement of the Intracellular C-terminus
- Fourfold Reduction of Water Permeability in Inner Medullary Collecting Duct of Aquaporin-4 Knockout Mice
- Functional Characterization of Five V2 Vasopressin Receptor Gene Mutations
- Functional Rescue of Vasopressin V2 Receptor Mutants in MDCK Cells by Pharmacochaperones: Relevance to Therapy of Nephrogenic Diabetes Insipidus
- Functional Rescue of the Constitutively Internalized V2 Vasopressin Receptor Mutant R137H by the Pharmacological Chaperone Action of SR49059
- G-Protein-Coupled Receptors: Molecular Mechanisms Involved in Receptor Activation and Selectivity of G-Protein Recognition
- Generation and Phenotype of Mice Harboring a Nonsense Mutation in the V2 Vasopressin Receptor Gene
- Genetics of Vasopressin Receptors
- Hereditary Vasopressin Resistance in Man and Mouse
- Heterogeneous AVPR2 Gene Mutations in Congenital Nephrogenic Diabetes Insipidus
- Heteroligomerization of an Aquaporin-2 Mutant with Wild-Type Aquaporin-2 and Their Misrouting to Late Endosomes/Lysosomes Explains Dominant Nephrogenic Diabetes Insipidus
- Hormone and Autacoid Regulation of cAMP Production in Rat IMCD Subsegments
- Identification and Characterization of Aquaporin-2 Water Channel Mutations Causing Nephrogenic Diabetes Insipidus with Partial Vasopressin Response
- Importance of the Mercury-Sensitive Cysteine on Function and Routing of AQP1 and AQP2 in Oocytes
- In Vivo Role of CLC Chloride Channels in the Kidney
- Kidney Damage in Long-Term Lithium Patients: A Cross-Sectional Study of Patients with 15 Years or More on Lithium
- Large-Scale Purification of Functional Recombinant Human Aquaporin-2
- Lithium-induced nephrogenic diabetes insipidus.
- Lithiumogenic Disorders of the Thyroid and Parathyroid Glands as Surgical Disease
- Loss of Calcineurin Aα Results in Altered Trafficking of AQP2 and in Nephrogenic Diabetes Insipidus
- Maturation of Receptor Proteins in Eukaryotic Expression Systems
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular Aspects of Water Transport
- Molecular and Cellular Defects in Nephrogenic Diabetes Insipidus
- Mutations in the Vasopressin V2 Receptor Gene in Families with Nephrogenic Diabetes Insipidus and Functional Expression of the Q-2 Mutant
- Nephrogenic Diabetes Insipidus Caused By Mutation of Tyr205: A Key Residue of V2 Vasopressin Receptor Function
- Nephrogenic Diabetes Insipidus. A V2 Vasopressin Receptor Unable to Stimulate Adenylyl Cyclase
- Nephrogenic Diabetes Insipidus: Functional Analysis of New AVPR2 Mutations Identified in Italian Families
- Neurogenic Disorders of Osmoregulation
- Novel Mutations in Aquaporin-2 Gene in Female Siblings with Nephrogenic Diabetes Insipidus: Evidence of Disrupted Water Channel Function
- Novel Vasopressin Type 2 (AVPR2) Gene Mutations in Brazilian Nephrogenic Diabetes Insipidus Patients
- Osmoregulation and Baroregulation of Plasma Vasopressin in Essential Hypertension
- Overt Nephrogenic Diabetes Insipidus in Mice Lacking the CLC-K1 Chloride Channel
- Pharmacochaperones Post-Translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-Type and Mutant Vasopressin V2 Receptors
- Pharmacologic Chaperones as a Potential Treatment for X-linked Nephrogenic Diabetes Insipidus
- Pharmacological Chaperones Rescue Cell-Surface Expression and Function of Misfolded V2 Vasopressin Receptor Mutants
- Pharmacological Chaperones in Nephrogenic Diabetes Insipidus: Possibilities for Clinical Application
- Pharmacological Chaperones: A New Twist on Receptor Folding
- Pharmacological Chaperones: Potential Treatment for Conformational Diseases
- Physiological Importance of Aquaporin Water Channels
- Physiological relevance of aquaporins: luxury or necessity?
- Physiology and Pathophysiology of the Aquaporin-2 Water Channel
- Platelet Vasopressin Receptors in Patients With Congenital Nephrogenic Diabetes Insipidus
- Proposed Cause of Marked Vasopressin Resistance in a Female with an X-Linked Recessive V2 Receptor Abnormality
- Recent Advances in Water Transport
- Reconstitution of Mutant V2 Vasopressin Receptors by Adenovirus-mediated Gene Transfer
- Renal Aquaporins
- Reverse Pharmacological Effect of Loop Diuretics and Altered rBSC1 Expression in Rats with Lithium Nephropathy
- Role of the Ca2+-Sensing Receptor in Divalent Mineral Ion Homeostasis
- Structural Implication for Receptor Oligomerization from Functional Reconstitution Studies of Mutant V2 Vasopressin Receptors
- Structure and Function of Aquaporin Water Channels
- Structure and Function of Kidney Water Channels
- The Effect of Eight V2 Vasopressin Receptor Mutations on Stimulation of Adenylyl Cyclase and Binding to Vasopressin
- The Interaction of Blood Osmolality and Blood Volume in Regulating Plasma Vasopressin in Man
- The Molecular Basis of Renal Tubular Transport Disorders
- The Molecular Structure of the Antidiuretic Hormone Elicited Water Channel
- The valve bladder syndrome: 20 years later.
- Transepithelial Water Flow Regulates Apical Membrane Retrieval in Antidiuretic Hormone-Stimulated Toad Urinary Bladder
- Truncated V2 Vasopressin Receptors as Negative Regulators of Wild-Type V2 Receptor Function
- Two Vasopressin Type 2 Receptor Gene Mutations R143P and Delta V278 in Patients with Nephrogenic Diabetes Insipidus Impair Ligand Binding of the Receptor
- Urinary Arginine Vasopressin (AVP) Measurement in Children: Water Deprivation Test Incorporating Urinary AVP
- V2 Vasopressin Receptor Dysfunction in Nephrogenic Diabetes Insipidus Caused By Different Molecular Mechanisms
- Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus
- Water Channels
Used in 10 Article bodies
Used in 10 Article bodies
- A Congenital Renal Tubular Defect
- Hereditary Vasopressin Resistance in Man and Mouse
- Importance of the Mercury-Sensitive Cysteine on Function and Routing of AQP1 and AQP2 in Oocytes
- Inborn Errors of Signal Transduction: Mutations in G Proteins and G Protein-coupled Receptors as a Cause of Disease
- Intracranial Calcification in Nephrogenic Diabetes Insipidus
- Lithium-Induced Nephrogenic Diabetes Insipidus Treated with Indomethacin
- Nephrogenic Diabetes Insipidus: Transmitted by Females and Appearing During Infancy in Males
- Proposed Cause of Marked Vasopressin Resistance in a Female with an X-Linked Recessive V2 Receptor Abnormality
- Risk Factors for Ifosfamide Nephrotoxicity in Children
- Role of Vasopressin in Abnormal Water Excretion in Cirrhotic Patients
Used in 193 Article translations
Used in 193 Article translations
- 1-Desamino-8-D-Arginine Vasopressin (DDAVP) in Patients with Congenital Nephrogenic Diabetes Insipidus
- A Fully Active Nonglycosylated V2 Vasopressin Receptor
- A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial Cells
- A Low Affinity Vasopressin V2-Receptor in Inherited Nephrogenic Diabetes Insipidus
- A Mouse Model to Test the in vivo Efficacy of Chemical Chaperones
- A Novel Deletion Mutation in the Arginine Vasopressin Receptor 2 Gene and Skewed X Chromosome Inactivation in a Female Patient with Congenital Nephrogenic Diabetes Insipidus
- A Novel Mechanism in Recessive Nephrogenic Diabetes Insipidus: Wild-Type Aquaporin-2 Rescues the Apical Membrane Expression of Intracellularly Retained AQP2-P262L
- A Role for K268 in V2R Folding
- ARDS Following Acute Lithium Carbonate Intoxication
- Acquired Nephrogenic Diabetes Insipidus Secondary to Distal Renal Tubular Acidosis and Nephrocalcinosis Associated with Sjogren's Syndrome
- Altered Expression of COX-1, COX-2, and mPGES in Rats with Nephrogenic and Central Diabetes Insipidus
- Aminoglycoside Pretreatment Partially Restores the Function of Truncated V2 Vasopressin Receptors Found in Patients with Nephrogenic Diabetes Insipidus
- Aminoglycoside-Mediated Rescue of a Disease-Causing Nonsense Mutation in the V2 Vasopressin Receptor Gene In Vitro and In Vivo
- An Aquaporin-2 Water Channel Mutant Which Causes Autosomal Dominant Nephrogenic Diabetes Insipidus is Retained in the Golgi Complex
- An Impaired Routing of Wild-type Aquaporin-2 after Tetramerization with an Aquaporin-2 Mutant Explains Dominant Nephrogenic Diabetes Insipidus
- An X-linked NDI Mutation Reveals a Requirement for Cell Surface V2R Expression
- Analysis of Vasopressin Receptor Type II (V2R) Gene in Three Japanese Pedigrees with Congenital Nephrogenic Diabetes Insipidus: Identification of a Family with Complete Deletion of the V2R Gene
- Antidiuretic Hormone Modulates Membrane Phosphoproteins in Toad Urinary Bladder and Retrieved Water Channel Containing Apical Membrane Vesicles
- Appropriate Polarization Following Pharmacological Rescue of V2 Vasopressin Receptors Encoded by X-Linked Nephrogenic Diabetes Insipidus Alleles Involves a Conformation of the Receptor That Also Attains Mature Glycosylation
- Aquaporin-2, a Vasopressin-sensitive Water Channel, and Nephrogenic Diabetes Insipidus
- Aquaporins: From Physiology to Nephrogenic Diabetes Insipidus
- Association of Calnexin With Wild Type and Mutant AVPR2 that Cause Nephrogenic Diabetes Insipidus
- Autosomal Recessive Nephrogenic Diabetes Insipidus Caused by an Aquaporin-2 Mutation
- Binding-, Intracellular Transport-, and Biosynthesis-Defective Mutants of Vasopressin Type 2 Receptor in Patients with X-Linked Nephrogenic Diabetes Insipidus
- Bladder Function Impairment in Aquaporin-2 Defective Nephrogenic Diabetes Insipidus
- Brief Report: A Molecular Defect in the Vasopressin V2-Receptor Gene Causing Nephrogenic Diabetes Insipidus
- Cellular Distribution of the Aquaporins: A Family of Water Channel Proteins
- Characterization of Vasopressin V2 Receptor Mutants in Nephrogenic Diabetes Insipidus in a Polarized Cell Model
- Characterization of an Aquaporin-2 Water Channel Gene Mutation Causing Partial Nephrogenic Diabetes Insipidus in a Mexican Family: Evidence of Increased Frequency of the Mutation in the Town of Origin
- Cloning of an Aquaporin Homologue Present in Water Channel Containing Endosomes of Toad Urinary Bladder
- Cloning, Characterization, and Chromosomal Mapping of Human Aquaporin of Collecting Duct
- Compartmentalization of cAMP-Dependent Signaling by Phosphodiesterase-4D is Involved in the Regulation of Vasopressin-Mediated Water Reabsorption in Renal Principal Cells
- Constitutive and Regulated Membrane Expression of Aquaporin 1 and Aquaporin 2 Water Channels in Stably Transfected LLC-PK1 Epithelial Cells
- Defective Aquaporin-2 Trafficking in Nephrogenic Diabetes Insipidus and Correction by Chemical Chaperones
- Defects of G Protein-Coupled Signal Transduction in Human Disease
- Derivatives of Somatic Cell Hybrids Which Carry the Human Gene Locus for Nephrogenic Diabetes Insipidus (NDI) Express Functional Vasopressin Renal V2-type Receptors
- Development and Characterization of a Mouse Cell Line Expressing the Human V2 Vasopressin Receptor Gene
- Diabetes Insipidus (Hendy, Bichet)
- Different Single Receptor Domains Determine the Distinct G Protein Coupling Profiles of Members of the Vasopressin Receptor Family
- Discovery of Aquaporins: a Breakthrough in Research on Renal Water Transport
- Disease-Causing V2 Vasopressin Receptors are Retained in Different Compartments of the Early Secretory Pathway
- Evidence for Stabilization of Aquaporin-2 Folding Mutants by N-linked Glycosylation in the Endoplasmic Reticulum
- Expression Studies of Two Vasopressin V2 Receptor Gene Mutations, R202C and 804insG, in Nephrogenic Diabetes Insipidus
- Folding and Cell Surface Expression of the Vasopressin V2 Receptor: Requirement of the Intracellular C-terminus
- Fourfold Reduction of Water Permeability in Inner Medullary Collecting Duct of Aquaporin-4 Knockout Mice
- Functional Analysis of Aquaporin-2 Mutants Associated with Nephrogenic Diabetes Insipidus by Yeast Expression
- Functional Involvement of VAMP/Synaptobrevin-2 in cAMP-Stimulated Aquaporin 2 Translocation in Renal Collecting Duct Cells
- Functional Rescue of Mutant V2 Vasopressin Receptors Causing Nephrogenic Diabetes Insipidus by a Co-Expressed Receptor Polypeptide
- Functional Rescue of Vasopressin V2 Receptor Mutants in MDCK Cells by Pharmacochaperones: Relevance to Therapy of Nephrogenic Diabetes Insipidus
- Functional Rescue of the Constitutively Internalized V2 Vasopressin Receptor Mutant R137H by the Pharmacological Chaperone Action of SR49059
- Functional Rescue of the Nephrogenic Diabetes Insipidus-Causing Vasopressin V2 Receptor Mutants G185C and R202C by a Second Site Suppressor Mutation
- Functional Role of the NPxxY Motif in Internalization of the Type 2 Vasopressin Receptor in LLC-PK1 Cells
- Functional Studies of Twelve Mutant V2 Vasopressin Receptors Related to Nephrogenic Diabetes Insipidus: Molecular Basis of a Mild Clinical Phenotype
- Functional Water Channels Are Present in Clathrin-coated Vesicles from Bovine Kidney but Not from Brain
- G-Protein-Coupled Receptors in Endocrine Disease
- G-Protein-Coupled Receptors: Molecular Mechanisms Involved in Receptor Activation and Selectivity of G-Protein Recognition
- GS-Activating Receptors: Modes of Transmembrane Signalling and Genetic Defects
- Gabapentin-Related Changes in Renal Function: Two Case Studies
- Genetic Restoration of Aldose Reductase to the Collecting Tubules Restores Maturation of the Urine Concentrating Mechanism
- Heat Shock Protein 70 Interacts with Aquaporin-2 (AQP2) and Regulates Its Trafficking
- Hemodynamic and Coagulation Responses to 1-desamino[8-D-arginine] Vasopressin in Patients with Congenital Nephrogenic Diabetes Insipidus
- Hereditary Vasopressin Resistance in Man and Mouse
- Heterogeneous AVPR2 Gene Mutations in Congenital Nephrogenic Diabetes Insipidus
- Heteroligomerization of an Aquaporin-2 Mutant with Wild-Type Aquaporin-2 and Their Misrouting to Late Endosomes/Lysosomes Explains Dominant Nephrogenic Diabetes Insipidus
- High Activity of Low-Michaelis-Menten Constant 3',5'-Cyclic Adenosine Monophosphate-Phosphodiesterase Isozymes in Renal Inner Medulla of Mice With Hereditary Nephrogenic Diabetes Insipidus
- Homer Smith: His Contribution to the Practice of Nephrology
- Hypertonicity Regulates the Aquaporin-2 Promoter Independently of Arginine Vasopressin
- Identification and Characterization of Aquaporin-2 Water Channel Mutations Causing Nephrogenic Diabetes Insipidus with Partial Vasopressin Response
- Identification of Rab3-, Rab5a- and Synaptobrevin II-like Proteins in a Preparation of Rat Kidney Vesicles Containing the Vasopressin-Regulated Water Channel
- Identification of a Novel A-kinase Anchoring Protein 18 Isoform and Evidence for its Role in the Vasopressin-induced Aquaporin-2 Shuttle in Renal Principal Cells
- Importance of the Mercury-Sensitive Cysteine on Function and Routing of AQP1 and AQP2 in Oocytes
- In Vitro Micro-Autoradiography of Atrial Natriuretic Peptide in Biopsy Specimens from Patients with Renal Diseases
- Inborn Errors of Signal Transduction: Mutations in G Proteins and G Protein-coupled Receptors as a Cause of Disease
- Increased Renal Responsiveness to Vasopressin and Enhanced V2 Receptor Signaling in RGS2-/- Mice
- Indomethacin Enhances Shuttling of Aquaporin-2 Despite Decreased Abundance in Rat Kidney
- Inherited Diseases of the Kidney
- Inhibition of Endocytosis Causes Phosphorylation (S256)-Independent Plasma Membrane Accumulation of AQP-2
- Insulin Potentiates AVP-induced AQP2 Expression in Cultured Renal Collecting Duct Principal Cells
- Intrafamilial Phenotype Variability in Nephrogenic Diabetes Insipidus
- Kidney Damage in Long-Term Lithium Patients: A Cross-Sectional Study of Patients with 15 Years or More on Lithium
- Kinetic Model of Water and Urea Permeability Regulation by Vasopressin in Collecting Duct
- Large-Scale Purification of Functional Recombinant Human Aquaporin-2
- Lithium Nephrotoxicity
- Lithium-Induced Nephrogenic Diabetes Insipidus Treated with Indomethacin
- Lithiumogenic Disorders of the Thyroid and Parathyroid Glands as Surgical Disease
- Long-Term Regulation of Urinary Concentrating Capacity
- MAL Decreases the Internalization of the Aquaporin-2 Water Channel
- Maturation of Receptor Proteins in Eukaryotic Expression Systems
- Mechanism of Antidiuresis Caused by Bendroflumethiazide in Conscious Rats with Diabetes Insipidus
- Mechanism of Vasopressin Action in the Renal Collecting Duct
- Mechanisms and Regulation of Water Permeability in Renal Epithelia
- Mechanisms and Regulation of Water Transport in the Kidney
- Mechanisms of Impaired Urinary Concentrating Ability in Adult Rats Treated Neonatally with Enalapril
- Mesalazine Associated Nephrogenic Diabetes Insipidus Presenting as Weight Loss
- Methyl-β-Cyclodextrin Induces Vasopressin-Independent Apical Accumulation of Aquaporin-2 in the Isolated, Perfused Rat Kidney
- Mild Nephrogenic Diabetes Insipidus Caused by Foxa1 Deficiency
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular Analysis of X-Linked Nephrogenic Diabetes Insipidus
- Molecular Aspects of Vasopressin Receptor Function
- Molecular Aspects of Water Transport
- Molecular Biology of Diabetes Insipidus
- Molecular Genetic Study of Congenital Nephrogenic Diabetes Insipidus and Rescue of Mutant Vasopressin V2 Receptor by Chemical Chaperones
- Molecular Insights into the Pathogenesis of Inherited Renal Tubular Disorders
- Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking
- Molecular and Cellular Biology of Vasopressin and Oxytocin Receptors and Action in the Kidney
- Mutations and Diseases of G Protein Coupled Receptors
- Mutations in the Founder of the MIP Gene Family Underlie Cataract Development in the Mouse
- Mutations in the V2 Vasopressin Receptor Gene are Associated with X-linked Nephrogenic Diabetes Insipidus
- Mutations in the Vasopressin V2 Receptor Gene in Families with Nephrogenic Diabetes Insipidus and Functional Expression of the Q-2 Mutant
- Mutations in the Vasopressin V2-Receptor Gene in Three Families of Italian Descent with Nephrogenic Diabetes Insipidus
- N-ethylmaleimide (NEM) Causes Aquaporin-2 Trafficking in the Renal Inner Medullary Collecting Duct by Direct Activation of Protein Kinase A
- Nephrogenic Diabetes Insipidus (Bichet - November 1998)
- Nephrogenic Diabetes Insipidus (Bichet)
- Nephrogenic Diabetes Insipidus Caused By Mutation of Tyr205: A Key Residue of V2 Vasopressin Receptor Function
- Nephrogenic Diabetes Insipidus in Mice Lacking All Nitric Oxide Synthase Isoforms
- Nephrogenic Diabetes Insipidus. A V2 Vasopressin Receptor Unable to Stimulate Adenylyl Cyclase
- Nephrogenic Diabetes Insipidus: Causes Revealed
- Nephrogenic Diabetes Insipidus: Clinical Symptoms, Pathogenesis, Genetics and Treatment
- New Mutations in the AQP2 Gene in Nephrogenic Diabetes Insipidus Resulting in Functional but Misrouted Water Channels
- Normal Fibrinolytic Responses to 1-Desamino-8-D-Arginine Vasopressin in Patients with Nephrogenic Diabetes Insipidus Caused by Mutations in the Aquaporin 2 Gene
- Novel Mutations in the V2 Vasopressin Receptor Gene in Two Pedigrees with Congenital Nephrogenic Diabetes Insipidus
- Novel Mutations in the V2 Vasopressin Receptor Gene of Patients with X-Linked Nephrogenic Diabetes Insipidus
- Novel Vasopressin Type 2 (AVPR2) Gene Mutations in Brazilian Nephrogenic Diabetes Insipidus Patients
- On Hereditary Diabetes Insipidus With Special Regard to a Sex-Linked Form
- Palmitoylation of the V2 Vasopressin Receptor
- Pathophysiology of Aquaporin-2 in Water Balance Disorders
- Pathophysiology of the Aquaporin Water Channels
- Patients with Autosomal Nephrogenic Diabetes Insipidus Homozygous for Mutations in the Aquaporin 2 Water-Channel Gene
- Pharmacochaperones Post-Translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-Type and Mutant Vasopressin V2 Receptors
- Pharmacologic Chaperones as a Potential Treatment for X-linked Nephrogenic Diabetes Insipidus
- Pharmacological Chaperones Rescue Cell-Surface Expression and Function of Misfolded V2 Vasopressin Receptor Mutants
- Pharmacological Chaperones in Nephrogenic Diabetes Insipidus: Possibilities for Clinical Application
- Pharmacological Chaperones: Potential Treatment for Conformational Diseases
- Phosphorylation of the V2 Vasopressin Receptor
- Physiology and Pathophysiology of Aquaporins
- Platelet Vasopressin Receptors in Patients With Congenital Nephrogenic Diabetes Insipidus
- Posterior Lobe of the Pituitary in Diabetes Insipidus: Dynamic MR Imaging
- Properties of the Human Arginine Vasopressin V2 Receptor after Site-Directed Mutagenesis of its Putative Palmitoylation Site
- Rat Kidney Papilla Contains Abundant Synaptobrevin Protein that Participates in the Fusion of Antidiuretic Hormone-regulated Water Channel-containing Endosomes In Vitro
- Recent Advances in Water Transport
- Reconstitution of Mutant V2 Vasopressin Receptors by Adenovirus-mediated Gene Transfer
- Renal Aquaporins
- Renal Function On and Off Lithium in Patients Treated with Lithium for 15 Years or More. A Controlled, Prospective Lithium-Withdrawal Study
- Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-Dependent Concentration of Urine
- Rescue of Vasopressin V2 Receptor Mutants by Chemical Chaperones: Specificity and Mechanism
- Rescue of a Nephrogenic Diabetes Insipidus-Causing Vasopressin V2 Receptor Mutant by Cell-Penetrating Peptides
- Reversed Polarized Delivery of an Aquaporin-2 Mutant Causes Dominant Nephrogenic Diabetes Insipidus
- Rho Inhibits cAMP-Induced Translocation of Aquaporin-2 into the Apical Membrane of Renal Cells
- Risk Factors for Ifosfamide Nephrotoxicity in Children
- Role of Aquaporin Water Channels in Kidney and Lung
- Role of Aquaporin-2 Water Channels in Urinary Concentration and Dilution Defects
- Role of Aquaporins in Water Balance Disorders
- Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels
- Short-Chain Ubiquitination Mediates the Regulated Endocytosis of the Aquaporin-2 Water Channel
- Stimulation of AQP2 Membrane Insertion in Renal Epithelial Cells In Vitro and In Vivo by the cGMP Phosphodiesterase Inhibitor Sildenafil Citrate (Viagra)
- Structure and Function of Kidney Water Channels
- Successful Treatment with Hydrochlorothiazide and Amiloride in an Infant with Congenital Nephrogenic Diabetes Insipidus
- Switch from an Aquaporin to a Glycerol Channel by Two Amino Acids Substitution
- The Aquaporin Family of Molecular Water Channels
- The Aquaporin Family of Water Channels in Kidney: an Update on Physiology and Pathophysiology of Aquaporin-2
- The Cellular Action of Antidiuretic Hormone
- The Effect of Eight V2 Vasopressin Receptor Mutations on Stimulation of Adenylyl Cyclase and Binding to Vasopressin
- The Hydrophobic Amino Acid Residues in the Membrane-Proximal C Tail of the G Protein-Coupled Vasopressin V2 Receptor are Necessary for Transport-Competent Receptor Folding
- The Ins and Outs of Aquaporin-2 Trafficking
- The Molecular Basis of Nephrogenic Diabetes Insipidus
- The Molecular Structure of the Antidiuretic Hormone Elicited Water Channel
- The Proteasome is Involved in the Degradation of Different Aquaporin-2 Mutants Causing Nephrogenic Diabetes Insipidus
- The Role of Membrane Turnover in the Water Permeability Response to Antidiuretic Hormone
- The Vasopressin Type 2 Receptor Gene. Chromosomal Localization and Its Role in Nephrogenic Diabetes Insipidus
- Therapeutic Potential of Vasopressin Receptor Antagonists
- Three Novel AVPR2 Mutations in Three Japanese Families with X-Linked Nephrogenic Diabetes Insipidus
- Transient Central Diabetes Insipidus in the Setting of Underlying Chronic Nephrogenic Diabetes Insipidus Associated with Lithium Use
- Transport Defects of Rabbit Inner Medullary Collecting Duct Cells in Obstructive Nephropathy
- Treatment of Congenital Nephrogenic Diabetes Insipidus by Hydrochlorothiazide and Cyclooxygenase-2 Inhibitor
- Two Novel Aquaporin-2 Mutations Responsible for Congenital Nephrogenic Diabetes Insipidus in Chinese Families
- Two Novel Mutations in the Aquaporin-2 and the Vasopressin V2 Receptor Genes in Patients with Congenital Nephrogenic Diabetes Insipidus
- Two Novel Mutations in the Vasopressin V2 Receptor Gene in Unrelated Japanese Kindreds with Nephrogenic Diabetes Insipidus
- Two Vasopressin Type 2 Receptor Gene Mutations R143P and Delta V278 in Patients with Nephrogenic Diabetes Insipidus Impair Ligand Binding of the Receptor
- Upregulation of Urea Transporter UT-A2 and Water Channels AQP2 and AQP3 in Mice Lacking Urea Transporter UT-B
- Urinary Concentrating Mechanism: The Role of the Inner Medulla
- Use of T1-weighted MR Imaging to Differentiate between Primary Polydipsia and Central Diabetes Insipidus
- V2 Vasopressin Receptor Dysfunction in Nephrogenic Diabetes Insipidus Caused By Different Molecular Mechanisms
- Vasopressin Effects on Urea and H20 Transport in Inner Medullary Collecting Duct Subsegments
- Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus
- Vasopressin V2 Receptor Mutants that Cause X-linked Nephrogenic Diabetes Insipidus: Analysis of Expression, Processing, and Function
- Vasopressin and Oxytocin Receptors
- Very Severe Self-Poisoning Lithium Carbonate Intoxication Causing a Myocardial Infarction
- Water Channels
- Water Channels in Cell Membranes
- Water Transport Across Mammalian Cell Membranes
- Xanthopterin-Induced Renal Dysfunction: A Reversible Model of Crystal Nephropathy
- cDNA Cloning of a Functional Water Channel From Toad Urinary Bladder Epithelium
- cDNA and Genomic Cloning of Mouse Aquaporin-2: Functional Analysis of an Orthologous Mutant Causing Nephrogenic Diabetes Insipidus
Used in 46 Proceeding abstracts
Used in 46 Proceeding abstracts
- A pharmacological chaperone acting at the V2-vasopressin receptor offers a treatment for Nephrogenic Diabetes Insipidus
- Action Mechanism of Pharmacological Chaperones Acting on the V2 Vasopressin Receptor in the Treatment of Nephrogenic Diabetes Insipidus
- An impaired routing of wild type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
- Analysis of naturally occurring and in vitro mutations of the V2 receptor gene interfering with proper splicing
- Aquaporin-2 Expression in Primary Cultures of Rat Inner Medullary Collecting Duct Cells - A New In-Vitro Model System Facilitating the Study of the Vasopressin-Regulated Antidiuretic Machinery at the Cellular Level
- Biochemical Characterization of Partial Nephrogenic Diabetes Insipidus (NDI) Phenotypes
- Calcineurin A-alpha knockout is a new model of nephrogenic diabetes insipidus
- Cell biological and functional analysis of five new Aquaporin-2 gene missense mutations in recessive Nephrogenic Diabetes Insipidus
- Chemical Chaperones as a Novel Therapeutic Strategy for NDI
- Clinical analysis of eight Japanese patients with congenital nephrogenic diabetes insipidus
- Collecting Duct Specific Gene Regulation: Creation And Use of Transgenic Mouse Models
- Decrease in urine volume and increase in urine osmolality after SR49059 administration in five adult male patients with X-linked nephrogenic diabetes insipidus
- Defective urinary concentrating function in transgenic mice lacking urea transporter UT-B
- Downregulation of renal aquaporins and sodium transporters in rats with bilateral ureteral obstruction (BUO) is prevented by a-MSH treatment
- Expressional alteration of sodium transporter in the thick ascending limb of Henle and urinary concentration
- Functional rescue of truncated V2-Vasopressin-receptors by aminoglycoside-induced misreading of nonsense-mutations
- GIP, a G protein coupled receptor interacting protein
- Gene Mutation Analysis of NDI patients in Japan
- Growth in males with (well-managed) nephrogenic diabetes insipidus
- High proportion of ROMK processing defects underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome
- Identification of sequence determinants that direct different intracellular folding pathways for kidney aquaporins
- Mutations of the vasopressin V2 receptor gene in X-linked Nephrogenic Diabetes Insipidus: functional analysis of receptor mutants and identification of new mutations in Italian families.
- Naturally occurring and in vitro mutations defining the role of the NPXXY motif in the vasopressin V2 receptor
- Nephrogenic Diabetes Insipidus Mutation Database
- Nephrogenic Diabetes Insipidus Patients in Japan
- New insights in water channel physiology revealed by transgenic mouse models
- Pharmacological Chaperones Functionally Rescue Misfolded V2-Vasopressin Receptor Mutants that Cause Nephrogenic Diabetes Insipidus: Potential Clinical Implications
- Phenotype of aquaporin knockout mice, and AQP2 misprocessing in NDI
- Production and purification of Aquaporin-2 and Vasopressin 2 Receptor: towards elucidation of the structure
- Prostaglandins as Stimulants of AQP2 Expression: a Possible Future Treatment for NDI?
- Purinergic Control of Medullary Collecting Duct Function: A Novel Vasopressin-independent Regulatory Mechanism
- Routing and function of mutant AQP2 water channels in nephrogenic diabetes insipidus
- Structural evolution of the V2 vasopressin receptor in mammals
- Structure of V2 vasopressin receptor oligomers: evidence for contact dimer formation
- Structure-Function Analysis of the V2 Vasopressin Receptor
- Supplementation of Receptor Fragments: An approach to Functionally Rescue Mutant V2 Vasopressin Receptors
- Targeting of the V2 Vasopressin Receptor Gene in Mice
- The Medical Geneticist's Perspective on NDI Research
- The novel Aquaporin-2 maturing protein 1 interacts with AQP2, inhibits its forskolin-induced translocation to the apical membrane, and reduces its expression
- The stoichiometry of phosphorylated and non-phosphorylated monomers in an aquaporin-2 tetramer determines its subcellular localization
- Toward gene therapy for nephrogenic diabetes insipidus
- Transport Defects of V2 Receptor Mutants Found in Patients with X-linked Nephrogenic Diabetes Insipidus
- V2 vasopressin receptor dysfunction in patients with nephrogenic diabetes insipidus is caused by different molecular mechanisms
- V2 vasopressin receptor function studied in mice and yeast
- V2 vasopressin receptor-deficient mouse model: Pathophysiological changes and therapeutical implications
- Variations in clinical phenotype associated with different mutations of the V2 receptor gene in X-linked recessive congenital nephrogenic DI (xCNDI)
Used in 54 Proceeding translations
Used in 54 Proceeding translations
- A pharmacological chaperone acting at the V2-vasopressin receptor offers a treatment for Nephrogenic Diabetes Insipidus
- Action Mechanism of Pharmacological Chaperones Acting on the V2 Vasopressin Receptor in the Treatment of Nephrogenic Diabetes Insipidus
- Amelioration of Polyuria in Nephrogenic Diabetes Insipidus due to Aquaporin-2 Deficiency
- An impaired routing of wild type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
- Biochemical Characterization of Partial Nephrogenic Diabetes Insipidus (NDI) Phenotypes
- Calcineurin A-alpha knockout is a new model of nephrogenic diabetes insipidus
- Candesartan treatment prevents dysregulation of AQP2, BSC-1 and NaPi2 in ureteral obstruction-induced NDI
- Collecting Duct Specific Gene Regulation: Creation And Use of Transgenic Mouse Models
- Comparative analysis of human and murine vasopressin V2 receptor genes and their encoded proteins reveal striking differences in their genomic structure and functional properties
- Consequences of tetramerization and expression levels of Aquaporin-2 in phenotype-genotype correlation studies in autosomal NDI
- Correction of age-related polyuria by dDAVP: Molecular involvement of aquaporins and urea transporters
- Decrease in urine volume and increase in urine osmolality after SR49059 administration in five adult male patients with X-linked nephrogenic diabetes insipidus
- Decreased Aquaporin-2 Water Channel Expression in Acquired Nephrogenic Diabetes Insipidus
- Determination of the functionality of AQP2 missense mutants in recessive NDI
- Downregulation of renal aquaporins and sodium transporters in rats with bilateral ureteral obstruction (BUO) is prevented by a-MSH treatment
- Functional investigations of the vasopressin regulated antidiuretic machinery in single inner medullary collecting duct (IMCD) cells
- Functional rescue of three vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus by a second site suppressor mutation
- Functional rescue of truncated V2-Vasopressin-receptors by aminoglycoside-induced misreading of nonsense-mutations
- Functional studies of twelve mutant V2 vasopressin receptors related to nephrogenic diabetes insipidus: molecular basis of a mild clinical phenotype.
- Gene Mutation Analysis of NDI patients in Japan
- Generation of Germ Line Heterozygous Mice for Aquaporin-2 Conditional Knock-Out and Knock-In Models of NDI
- Growth in males with (well-managed) nephrogenic diabetes insipidus
- High proportion of ROMK processing defects underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome
- Hormone-regulated intrenalization of the vasopressin V2 receptor in a polarized renal collecting duct cell system
- Identification of sequence determinants that direct different intracellular folding pathways for kidney aquaporins
- Long-term regulation of aquaporin-2: a possible therapeutic approach to NDI?
- Mineralocorticoid receptor mediated ENaC and AQP2 regulation in rats with lithium-induced NDI
- Molecular mechanisms underlying dominant Nephrogenic Diabetes Insipidus caused by mutations in the AQP2 gene
- Naturally occurring and in vitro mutations defining the role of the NPXXY motif in the vasopressin V2 receptor
- Nephrogenic diabetes insipidus in Italian families
- New insights in water channel physiology revealed by transgenic mouse models
- Pharmacological Chaperones Functionally Rescue Misfolded V2-Vasopressin Receptor Mutants that Cause Nephrogenic Diabetes Insipidus: Potential Clinical Implications
- Pharmacological chaperones functionally rescue misfolded mutant V2 vasopressin receptors that cause nephrogenic diabetes insipidus
- Phenotype of aquaporin knockout mice, and AQP2 misprocessing in NDI
- Progress in the function and structure of aquaporin-1 and aquaporin-2
- Quality control of nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants in the ER and in the ER/Golgi intermediate compartment
- Regulation and distribution of phosphorylated aquaporin-2 (AQP2) in rat kidney collecting duct principal cells
- Regulation of AQP2 trafficking and recycling by dopamine, PGE2 and ANP: involvement of AQP2-S256 phosphorylation
- Regulation of Aquaporin-2 trafficking by Vasopressin in Renal Collecting Duct: Roles of Ryanodine-Sensitive Ca2+ Stores and Calmodulin
- Routing and function of mutant AQP2 water channels in nephrogenic diabetes insipidus
- Structural evolution of the V2 vasopressin receptor in mammals
- Structure of V2 vasopressin receptor oligomers: evidence for contact dimer formation
- Structure-Function Analysis of the V2 Vasopressin Receptor
- Supplementation of Receptor Fragments: An approach to Functionally Rescue Mutant V2 Vasopressin Receptors
- The Medical Geneticist's Perspective on NDI Research
- The novel Aquaporin-2 maturing protein 1 interacts with AQP2, inhibits its forskolin-induced translocation to the apical membrane, and reduces its expression
- Toward a mouse model of human non-X-linked NDI
- Transport Defects of V2 Receptor Mutants Found in Patients with X-linked Nephrogenic Diabetes Insipidus
- Two new Aquaporin-2 mutations responsible for Congenital Nephrogenic Diabetes Insipidus
- Urinary Concentrating Defect in Mice With Selective Deletion of Collecting-Duct Urea Transporter Isoforms, UT-A1 and UT-A3
- V2 vasopressin receptor dysfunction in patients with nephrogenic diabetes insipidus is caused by different molecular mechanisms
- V2 vasopressin receptor function studied in mice and yeast
- V2 vasopressin receptor mutants responsible for nephrogenic diabetes insipidus associate with the molecular chaperones calnexin and Hsp70
- V2 vasopressin receptor-deficient mouse model: Pathophysiological changes and therapeutical implications
Used in 143 Term definitions
Used in 143 Term definitions
- ß-endorphin
- APUD cells
- G protein-coupled receptors
- NDI Abstract of Article: 510
- Quick's test
- SDS-polyacrylamide gel electrophoresis
- activity
- adrenocorticotropic hormone
- aid
- amyloidosis
- analog
- analogous
- analogue
- anthracycline
- apparatus
- autocrine
- blood tests
- breakdown
- calnexin
- cancer
- cardiogenic shock
- ceruloplasmin
- character
- chiropractic
- cobalt
- cofactor
- compensate
- compensation
- competence
- conservation
- conservative
- creatinine
- cyclic guanosine monophosphate
- death
- differentiate
- differentiated
- disease
- diseases
- disorder
- disorders
- electrical signal
- error
- excretion
- faculty
- functional
- functional analysis
- gate
- gene
- general paresis
- genes
- germ cell
- germ cells
- glandula pinealis
- glomus caroticum
- gradient
- hematologic
- histology
- hydrocephalus
- hyperactivity
- hypogonadism
- hypoparathyroidism
- immune system
- immunoglobulins
- immunology
- inactivating mutations
- incapable
- inflected
- inherited disorder
- insufficiency
- insufficient
- interference
- interstitial cells
- isoform
- isoforms
- kidney disease
- kidney disorders
- kidney function tests
- labor
- liver disease
- loss-of-function mutation
- lymphocyte
- lymphocytes
- mechanism
- mechanisms
- medullary principal cell
- member
- metestrus
- microfilament
- microfilaments
- mimetic
- mind
- mutated gene
- mutation
- neurofilament
- organ
- orthopedics
- pancreas
- paracrine
- paralysis
- parameter
- periodontal ligament
- poison
- poisons
- principal cell
- principal cells
- probability distribution
- property
- protein
- proteins
- renal function
- renal insufficiency
- restrictive cardiomyopathy
- rudiment
- scleroproteins
- secretin
- sensory neuron
- shock
- sodium benzoate
- sodium dodecyl sulfate-polyacrylamide gel electrophoresis
- specific
- spleen
- stomach
- suppress
- suppressed
- suppression
- suspended
- synthetic AVP
- system
- terminal bronchioles
- terminal web
- thalamus
- thymus
- thyroid gland
- tissue
- tissue culture
- tissue cultures
- tonofibril
- tract
- truncated protein
- variation
- vary
- vasopressin
- yolk sac



